VAPA_MOUSE - dbPTM
VAPA_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID VAPA_MOUSE
UniProt AC Q9WV55
Protein Name Vesicle-associated membrane protein-associated protein A
Gene Name Vapa
Organism Mus musculus (Mouse).
Sequence Length 249
Subcellular Localization Endoplasmic reticulum membrane
Single-pass type IV membrane protein . Cell membrane
Single-pass type IV membrane protein . Cell junction, tight junction . Nucleus membrane . Present in the plasma membrane and in intracellular vesicles, together w
Protein Description Binds to OSBPL3, which mediates recruitment of VAPA to plasma membrane sites. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With OSBPL3, may regulate ER morphology. May play a role in vesicle trafficking..
Protein Sequence MASASGAMAKHEQILVLDPPSDLKFKGPFTDVVTTNLKLQNPSDRKVCFKVKTTAPRRYCVRPNSGIIDPGSIVTVSVMLQPFDYDPNEKSKHKFMVQTIFAPPNISDMEAVWKEAKPDELMDSKLRCVFEMPNENDKLNDMEPSKAVPLNASKQDGPLPKPHSVSLNDTETRKLMEECKRLQGEMMKLSEENRHLRDEGLRLRKVAHSDKPGSTSAVSFRDNVTSPLPSLLVVIAAIFIGFFLGKFIL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MASASGAMA
------CCCCCCCCC		17.50-
3Phosphorylation-----MASASGAMAK
-----CCCCCCCCCC		22.9723527152
5Phosphorylation---MASASGAMAKHE
---CCCCCCCCCCCC		25.2922324799
24MalonylationLDPPSDLKFKGPFTD
ECCCCCCCCCCCCCC		50.4426320211
24AcetylationLDPPSDLKFKGPFTD
ECCCCCCCCCCCCCC		50.4423806337
26UbiquitinationPPSDLKFKGPFTDVV
CCCCCCCCCCCCCEE		65.1827667366
26AcetylationPPSDLKFKGPFTDVV
CCCCCCCCCCCCCEE		65.1823806337
52UbiquitinationRKVCFKVKTTAPRRY
CCEEEEEECCCCCEE		40.5227667366
65PhosphorylationRYCVRPNSGIIDPGS
EEEECCCCCCCCCCC		33.7725338131
117AcetylationEAVWKEAKPDELMDS
HHHHHHCCHHHHHHC		54.8423954790
125AcetylationPDELMDSKLRCVFEM
HHHHHHCCCEEEEEC		35.3723201123
125MalonylationPDELMDSKLRCVFEM
HHHHHHCCCEEEEEC		35.3726320211
146UbiquitinationLNDMEPSKAVPLNAS
CCCCCCCCCCCCCCC		65.2122790023
153PhosphorylationKAVPLNASKQDGPLP
CCCCCCCCCCCCCCC		29.7629472430
154MalonylationAVPLNASKQDGPLPK
CCCCCCCCCCCCCCC		50.4226320211
154UbiquitinationAVPLNASKQDGPLPK
CCCCCCCCCCCCCCC		50.42-
161MalonylationKQDGPLPKPHSVSLN
CCCCCCCCCCCCCCC		64.1526320211
161AcetylationKQDGPLPKPHSVSLN
CCCCCCCCCCCCCCC		64.1523201123
161UbiquitinationKQDGPLPKPHSVSLN
CCCCCCCCCCCCCCC		64.15-
164PhosphorylationGPLPKPHSVSLNDTE
CCCCCCCCCCCCHHH		23.1727742792
166PhosphorylationLPKPHSVSLNDTETR
CCCCCCCCCCHHHHH		25.1926824392
170PhosphorylationHSVSLNDTETRKLME
CCCCCCHHHHHHHHH		37.8825159016
172PhosphorylationVSLNDTETRKLMEEC
CCCCHHHHHHHHHHH		34.8925159016
179S-nitrosylationTRKLMEECKRLQGEM
HHHHHHHHHHHHHHH		1.6621278135
179S-nitrosocysteineTRKLMEECKRLQGEM
HHHHHHHHHHHHHHH		1.66-
180MalonylationRKLMEECKRLQGEMM
HHHHHHHHHHHHHHH		60.4626320211
184UbiquitinationEECKRLQGEMMKLSE
HHHHHHHHHHHHHHH		29.3827667366
187UbiquitinationKRLQGEMMKLSEENR
HHHHHHHHHHHHHHH		3.2527667366
188AcetylationRLQGEMMKLSEENRH
HHHHHHHHHHHHHHH		47.7723954790
188UbiquitinationRLQGEMMKLSEENRH
HHHHHHHHHHHHHHH		47.7727667366
205MalonylationDEGLRLRKVAHSDKP
HHCCHHEEEECCCCC		48.6526320211
205UbiquitinationDEGLRLRKVAHSDKP
HHCCHHEEEECCCCC		48.6527667366
209PhosphorylationRLRKVAHSDKPGSTS
HHEEEECCCCCCCCC		37.2822324799
211MalonylationRKVAHSDKPGSTSAV
EEEECCCCCCCCCEE		55.0526320211
211UbiquitinationRKVAHSDKPGSTSAV
EEEECCCCCCCCCEE		55.05-
211AcetylationRKVAHSDKPGSTSAV
EEEECCCCCCCCCEE		55.0523954790
214PhosphorylationAHSDKPGSTSAVSFR
ECCCCCCCCCEEEHH		27.9326824392
215PhosphorylationHSDKPGSTSAVSFRD
CCCCCCCCCEEEHHC		26.9827742792
216PhosphorylationSDKPGSTSAVSFRDN
CCCCCCCCEEEHHCC		28.5026824392
219PhosphorylationPGSTSAVSFRDNVTS
CCCCCEEEHHCCCCC		17.8025159016
226UbiquitinationSFRDNVTSPLPSLLV
EHHCCCCCCHHHHHH		21.8427667366
229UbiquitinationDNVTSPLPSLLVVIA
CCCCCCHHHHHHHHH		26.7327667366
243UbiquitinationAAIFIGFFLGKFIL-
HHHHHHHHHHHHCC-		8.0827667366
246UbiquitinationFIGFFLGKFIL----
HHHHHHHHHCC----		31.2327667366
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of VAPA_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of VAPA_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of VAPA_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of VAPA_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of VAPA_MOUSE

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Related Literatures of Post-Translational Modification

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