FMNL3_MOUSE - dbPTM
FMNL3_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FMNL3_MOUSE
UniProt AC Q6ZPF4
Protein Name Formin-like protein 3
Gene Name Fmnl3
Organism Mus musculus (Mouse).
Sequence Length 1028
Subcellular Localization Cytoplasm . Cell membrane
Lipid-anchor . Enriched in lamellipodia.
Protein Description Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Required for developmental angiogenesis. In this process, required for microtubule reorganization and for efficient endothelial cell elongation. In quiescent endothelial cells, triggers rearrangement of the actin cytoskeleton, but does not alter microtubule alignement..
Protein Sequence MGNLESTDGGPGEPPSVPLLLPPGKTPMPEPCELEERFALVLSSMNLPPDKARLLRQYDNEKKWDLICDQERFQVKNPPHTYIQKLQSFLDPNVTRKKFRRRVQESTKVLRELEISLRTNHIGWVREFLNDENKGLDVLVDYLSFAQCSVMFDFEGLESGDDGAFDKLRSWSRSIEDLQPPNALSAPFTNSLARSARQSVLRYSTLPGRRALKNSRLVSQKDDVHVCILCLRAIMNYQYGFNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILAAFDNFKEVCKELHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVEDMNFRVHLQYEFTKLGLEEFLQKSRHTESEKLQVQIQAYLDNVFDVGGLLEDAETKNVALEKVEELEEHVSHLTEKLLDLENENMMRVAELEKQLLQREKELESIKETYENTSNQVHTLRRLIKEKEEAFQRRCHLEPSARGLESMGGEALARVGPTELTEGIPPSDLDLLAPAPPTEETLPLPPPPAPPLPPPPPPLPDKCPPAPPLPGAAPSVVLTVGLSAIRIKKPIKTKFRLPVFNWTALKPNQINGTVFSELDDEKILEDLDLDRFEELFKTKAQGPALDLICSKNKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEEICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKVERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPELANFWQELHFVEKAAAVSLENVLLDVKELGRGMELIRRECSIHDNSVLRNFLSTNEGKLDKLQRDAKTAEEAYNAVVRYFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEARKKQEEVMREKQLAQEAKKLDAKTPSQRNKWQQQELIAELRRRQAKEHRPVYEGKDGTIEDIITVLKSVPFTARTAKRGSRFFCDAAHHDESNC
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Myristoylation------MGNLESTDG
------CCCCCCCCC		59.75-
88PhosphorylationTYIQKLQSFLDPNVT
HHHHHHHHHCCCCCC		37.9125777480
95PhosphorylationSFLDPNVTRKKFRRR
HHCCCCCCHHHHHHH		43.3327087446
170PhosphorylationGAFDKLRSWSRSIED
CHHHHHHHHHHCHHH		39.5826239621
172PhosphorylationFDKLRSWSRSIEDLQ
HHHHHHHHHCHHHCC		19.8626239621
174PhosphorylationKLRSWSRSIEDLQPP
HHHHHHHCHHHCCCC		25.4726824392
185PhosphorylationLQPPNALSAPFTNSL
CCCCCCCCCCCCHHH		31.3326643407
191PhosphorylationLSAPFTNSLARSARQ
CCCCCCHHHHHHHHH		21.9821659604
199PhosphorylationLARSARQSVLRYSTL
HHHHHHHHHHHHCCC		19.9829514104
203PhosphorylationARQSVLRYSTLPGRR
HHHHHHHHCCCCCHH		11.2226239621
204PhosphorylationRQSVLRYSTLPGRRA
HHHHHHHCCCCCHHH		19.6226239621
205PhosphorylationQSVLRYSTLPGRRAL
HHHHHHCCCCCHHHH		28.2126239621
358UbiquitinationGLEEFLQKSRHTESE
CHHHHHHHCCCCCCH		52.1622790023
453PhosphorylationNTSNQVHTLRRLIKE
HHHHHHHHHHHHHHH		24.0926824392
624PhosphorylationPALDLICSKNKTAQK
HHHHHHCCCCHHHHH		32.0629514104
634PhosphorylationKTAQKAASKVTLLEA
HHHHHHHHHCHHHHH		32.3029514104
692UbiquitinationLPTEAEVKLLRQYER
CCCHHHHHHHHHHHH		33.0522790023
722MethylationLLFSKVERLTQRMAG
HHHHHHHHHHHHHHH		46.12-
726MethylationKVERLTQRMAGMAFL
HHHHHHHHHHHHHHH		16.22-
776PhosphorylationIILALGNYMNSSKRG
HHHHHHHHHCCCCCC		8.8928059163
780PhosphorylationLGNYMNSSKRGAVYG
HHHHHCCCCCCCCCE		22.7428059163
924PhosphorylationVFVRFIRSYKEAEQE
HHHHHHHHHHHHHHH		35.4225338131
958PhosphorylationAKKLDAKTPSQRNKW
HHHCCCCCHHHCCHH		29.8729514104
960PhosphorylationKLDAKTPSQRNKWQQ
HCCCCCHHHCCHHHH		47.1824719451
986PhosphorylationAKEHRPVYEGKDGTI
HHHHCCCCCCCCCCH		22.9629514104
992PhosphorylationVYEGKDGTIEDIITV
CCCCCCCCHHHHHHH		31.1828066266
1014PhosphorylationARTAKRGSRFFCDAA
HHCCCCCCCEECCCC		29.9216141072
1026PhosphorylationDAAHHDESNC-----
CCCCCCCCCC-----		49.9426643407
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of FMNL3_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FMNL3_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FMNL3_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of FMNL3_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FMNL3_MOUSE

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Related Literatures of Post-Translational Modification

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