BAG6_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BAG6_MOUSE
• UniProt AC: Q9Z1R2
• Protein Name: Large proline-rich protein BAG6 {ECO:0000305}
• Gene Name: Bag6 {ECO:0000312|MGI:MGI:1919439}
• Organism: Mus musculus (Mouse).
• Sequence Length: 1154
• Subcellular Localization: Cytoplasm, cytosol . Nucleus . Secreted, exosome . Normally localized in cytosol and nucleus, it can also be released extracellularly, in exosomes, by tumor and myeloid dendritic cells.
• Protein Description: ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins. [PubMed: 18056262]
• Protein Sequence: MEPSDSASTAMEEPDSLEVLVKTLDSQTRTFIVGAQMNVKEFKEHIAASVSIPSEKQRLIYQGRVLQDDKKLQEYNVGGKVIHLVERAPPQTQLPSGASSGTGSASATHGGAPLPGTRGPGASVHDRNANSYVMVGTFNLPSDGSAVDVHINMEQAPIQSEPRVRLVMAQHMIRDIQTLLSRMECRGGTQAQASQPPPQTPQTVASETVALNSQTSEPVESEAPPREPMESEEMEERPPTQTPELAPSGPAPAGPAPAGPAPAPETNAPNHPSPAEHVEVLQELQRLQRRLQPFLQRYCEVLGAAATTDYNNNHEGREEDQRLINLVGESLRLLGNTFVALSDLRCNLACAPPRHLHVVRPMSHYTTPMVLQQAAIPIQINVGTTVTMTGNGARPPPAPGAEAATPGSAQATSLPPSSTTVDSSTEGAPPPGPAPPPASSHPRVIRISHQSVEPVVMMHMNIQDSGAQPGGVPSAPTGPLGPPGHGQTLGQQVPGFPTAPTRVVIARPTPPQARPSHPGGPPVSGALQGAGLGTNTSLAQMVSGLVGQLLMQPVLVAQGTPGMAQAQAQAQAQAQAQAQAPAPAPAPAPAPATASASAGTTNTATTAGPAPGGPAQPPPPQPSAADLQFSQLLGNLLGPAGPGAGGPGMASPTITVAMPGVPAFLQGMTDFLQASQTAPPPPPPPPPPPPAPEQQSTPPPGSPSGGTASPGGLGPESLPPEFFTSVVQGVLSSLLGSLGARAGSSESIAAFIQRLSGSSNIFEPGADGALGFFGALLSLLCQNFSMVDVVMLLHGHFQPLQRLQPQLRSFFHQHYLGGQEPTPSNIRMATHTLITGLEEYVRESFSLVQVQPGVDIIRTNLEFLQEQFNSIAAHVLHCTDSGFGARLLELCNQGLFECLALNLHCLGGQQMELAAVINGRIRRMSRGVNPSLVSWLTTMMGLRLQVVLEHMPVGPDAILRYVRRVGDPPQTLPEEPMEVQGAERTSPEPQRENASPAPGTTAEEAMSRGPPPAPEGGSRDEQDGASADAEPWAAAVPPEWVPIIQQDIQSQRKVKPQPPLSDAYLSGMPAKRRKTMQGEGPQLLLSEAVSRAAKAAGARPLTSPESLSRDLEAPEVQESYRQQLRSDIQKRLQEDPNYSPQRFPNAHRAFADDP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEPSDSAS -------CCCCCCCC	59.92	-
40	Ubiquitination	VGAQMNVKEFKEHIA EEEEECHHHHHHHHH	53.05	22790023
56	Ubiquitination	SVSIPSEKQRLIYQG HCCCCHHHHHHHEEC	45.09	22790023
71	Ubiquitination	RVLQDDKKLQEYNVG EECCCCHHHEEEECC	63.50	22790023
80	Ubiquitination	QEYNVGGKVIHLVER EEEECCCEEEEEHHC	31.89	22790023
96	Phosphorylation	PPQTQLPSGASSGTG CCCCCCCCCCCCCCC	56.43	25338131
99	Phosphorylation	TQLPSGASSGTGSAS CCCCCCCCCCCCCCC	32.59	25338131
100	Phosphorylation	QLPSGASSGTGSASA CCCCCCCCCCCCCCC	39.58	25293948
102	Phosphorylation	PSGASSGTGSASATH CCCCCCCCCCCCCCC	29.88	25293948
104	Phosphorylation	GASSGTGSASATHGG CCCCCCCCCCCCCCC	20.91	25293948
106	Phosphorylation	SSGTGSASATHGGAP CCCCCCCCCCCCCCC	35.08	25293948
108	Phosphorylation	GTGSASATHGGAPLP CCCCCCCCCCCCCCC	20.68	25293948
117	Phosphorylation	GGAPLPGTRGPGASV CCCCCCCCCCCCCCC	30.43	25293948
451	Phosphorylation	VIRISHQSVEPVVMM EEEEEECCCCCEEEE	24.03	22802335
465	Phosphorylation	MHMNIQDSGAQPGGV EEEEECCCCCCCCCC	21.47	22802335
474	Phosphorylation	AQPGGVPSAPTGPLG CCCCCCCCCCCCCCC	44.46	22802335
937	Phosphorylation	PSLVSWLTTMMGLRL HHHHHHHHHHHHHHH	13.34	22802335
938	Phosphorylation	SLVSWLTTMMGLRLQ HHHHHHHHHHHHHHH	11.73	22802335
971	Phosphorylation	RVGDPPQTLPEEPME HHCCCCCCCCCCCCC	50.48	27742792
985	Phosphorylation	EVQGAERTSPEPQRE CCCCCCCCCCCCCCC	39.89	25521595
986	Phosphorylation	VQGAERTSPEPQREN CCCCCCCCCCCCCCC	33.22	25521595
995	Phosphorylation	EPQRENASPAPGTTA CCCCCCCCCCCCCCH	32.93	27087446
1000	Phosphorylation	NASPAPGTTAEEAMS CCCCCCCCCHHHHHH	23.05	27742792
1001	Phosphorylation	ASPAPGTTAEEAMSR CCCCCCCCHHHHHHC	37.68	27742792
1006	Oxidation	GTTAEEAMSRGPPPA CCCHHHHHHCCCCCC	2.95	17242355
1007	Phosphorylation	TTAEEAMSRGPPPAP CCHHHHHHCCCCCCC	40.93	25619855
1018	Phosphorylation	PPAPEGGSRDEQDGA CCCCCCCCCCCCCCC	47.63	22807455
1055	Ubiquitination	IQSQRKVKPQPPLSD HHHCCCCCCCCCCCH	40.76	22790023
1074	Ubiquitination	GMPAKRRKTMQGEGP CCCCCCCCCCCCCCH	53.00	22790023
1075	Phosphorylation	MPAKRRKTMQGEGPQ CCCCCCCCCCCCCHH	16.96	26239621
1102	Phosphorylation	AAGARPLTSPESLSR HCCCCCCCCHHHHHH	44.94	24925903
1103	Phosphorylation	AGARPLTSPESLSRD CCCCCCCCHHHHHHC	34.06	25521595
1106	Phosphorylation	RPLTSPESLSRDLEA CCCCCHHHHHHCCCC	34.72	22324799
1108	Phosphorylation	LTSPESLSRDLEAPE CCCHHHHHHCCCCHH	32.78	25521595
1138	Phosphorylation	RLQEDPNYSPQRFPN HHHHCCCCCCCCCCC	27.41	27149854
1139	Phosphorylation	LQEDPNYSPQRFPNA HHHCCCCCCCCCCCH	22.61	26824392

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BAG6_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BAG6_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BAG6_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AIFM1_MOUSE	Aifm1	physical	18056262
HAVR2_MOUSE	Havcr2	physical	22863785
TRAF6_MOUSE	Traf6	physical	27501752

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-986 AND SER-995, ANDMASS SPECTROMETRY.
PubMed: 17242355