HAVR2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HAVR2_MOUSE
• UniProt AC: Q8VIM0
• Protein Name: Hepatitis A virus cellular receptor 2 homolog
• Gene Name: Havcr2
• Organism: Mus musculus (Mouse).
• Sequence Length: 281
• Subcellular Localization: Isoform 1: Membrane ; Single-pass type I membrane protein . Cell junction . Localizes to the immunological synapse between CD8+ T-cells and target cells.; Isoform 2: Secreted .
• Protein Description: Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand. [PubMed: 18006747 Regulates macrophage activation]
• Protein Sequence: MFSGLTLNCVLLLLQLLLARSLENAYVFEVGKNAYLPCSYTLSTPGALVPMCWGKGFCPWSQCTNELLRTDERNVTYQKSSRYQLKGDLNKGDVSLIIKNVTLDDHGTYCCRIQFPGLMNDKKLELKLDIKAAKVTPAQTAHGDSTTASPRTLTTERNGSETQTLVTLHNNNGTKISTWADEIKDSGETIRTAIHIGVGVSAGLTLALIIGVLILKWYSCKKKKLSSLSLITLANLPPGGLANAGAVRIRSEENIYTIEENVYEVENSNEYYCYVNSQQPS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
74	N-linked_Glycosylation	LLRTDERNVTYQKSS HHCCCCCCCCCCCCC	28.56	-
100	N-linked_Glycosylation	DVSLIIKNVTLDDHG CEEEEEEECEECCCC	22.92	-
146	O-linked_Glycosylation	QTAHGDSTTASPRTL CCCCCCCCCCCCCEE	30.99	-
172	N-linked_Glycosylation	LVTLHNNNGTKISTW EEEEECCCCCEEEEE	65.90	-
256	Phosphorylation	IRSEENIYTIEENVY EECCCCEEEEECCEE	17.16	-
263	Phosphorylation	YTIEENVYEVENSNE EEEECCEEEEECCCE	26.32	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
256	Y	Phosphorylation	Kinase	ITK	Q03526	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HAVR2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HAVR2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BAG6_MOUSE	Bag6	physical	22863785

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.