AP1G1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AP1G1_MOUSE
• UniProt AC: P22892
• Protein Name: AP-1 complex subunit gamma-1
• Gene Name: Ap1g1
• Organism: Mus musculus (Mouse).
• Sequence Length: 822
• Subcellular Localization: Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.
• Protein Description: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules..
• Protein Sequence: MPAPIRLRELIRTIRTARTQAEEREMIQKECAAIRSSFREEDNTYRCRNVAKLLYMHMLGYPAHFGQLECLKLIASQKFTDKRIGYLGAMLLLDERQDVHLLMTNCIKNDLNHSTQFVQGLALCTLGCMGSSEMCRDLAGEVEKLLKTSNSYLRKKAALCAVHVIRKVPELMEMFLPATKNLLNEKNHGVLHTSVVLLTEMCERSPDMLAHFRKLVPQLVRILKNLIMSGYSPEHDVSGISDPFLQVRILRLLRILGRNDDDSSEAMNDILAQVATNTETSKNVGNAILYETVLTIMDIKSESGLRVLAINILGRFLLNNDKNIRYVALTSLLKTVQTDHNAVQRHRSTIVDCLKDLDVSIKRRAMELSFALVNGNNIRGMMKELLYFLDSCEPEFKADCASGIFLAAEKYAPSKRWHIDTIMRVLTTAGSYVRDDAVPNLIQLITNSVEMHAYTVQRLYKAILGDYSQQPLVQVAAWCIGEYGDLLVSGQCEEEEPIQVTEDEVLDILESVLISNMSTSVTRGYALTAIMKLSTRFTCTVNRIKKVVSIYGSSIDVELQQRAVEYNALFKKYDHMRSALLERMPVMEKVTTNGPSEIVQTNGETEPAPLETKPPPSGPQPTSQANDLLDLLGGNDITPVIPTAPTSKPASAGGELLDLLGDITLTGAPAAAPTPASVPQISQPPFLLDGLSSQPLFNDIAPGIPSITAYSKNGLKIEFTFERSNTNPSVTVITIQASNSTELDMTDFVFQAAVPKTFQLQLLSPSSSVVPAFNTGTITQVIKVLNPQKQQLRMRIKLTYNHKGSAMQDLAEVNNFPPQSWQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
31	Glutathionylation	REMIQKECAAIRSSF HHHHHHHHHHHHHHH	3.90	24333276
45	Phosphorylation	FREEDNTYRCRNVAK HCCCCCCHHHHHHHH	17.61	8225075
78	Acetylation	LKLIASQKFTDKRIG HHHHHCCCCCCCCHH	47.97	22902405
144	Acetylation	DLAGEVEKLLKTSNS HHHHHHHHHHHHCCH	65.38	22826441
147	Malonylation	GEVEKLLKTSNSYLR HHHHHHHHHCCHHHH	61.41	26320211
151	Phosphorylation	KLLKTSNSYLRKKAA HHHHHCCHHHHHHHH	25.88	101546461
160	S-palmitoylation	LRKKAALCAVHVIRK HHHHHHHHHHHHHHH	2.97	28526873
167	Acetylation	CAVHVIRKVPELMEM HHHHHHHHCHHHHHH	51.52	23806337
229	Phosphorylation	ILKNLIMSGYSPEHD HHHHHHHCCCCCCCC	27.82	20415495
231	Phosphorylation	KNLIMSGYSPEHDVS HHHHHCCCCCCCCCC	17.47	29899451
232	Phosphorylation	NLIMSGYSPEHDVSG HHHHCCCCCCCCCCC	27.60	20415495
238	Phosphorylation	YSPEHDVSGISDPFL CCCCCCCCCCCCHHH	36.14	29899451
362	Ubiquitination	KDLDVSIKRRAMELS HCCCHHHHHHHHHHH	28.46	-
546	Ubiquitination	CTVNRIKKVVSIYGS EEHHHHHHHHEEECC	45.56	-
571	Acetylation	VEYNALFKKYDHMRS HHHHHHHHHHHHHHH	51.80	22902405
571	Ubiquitination	VEYNALFKKYDHMRS HHHHHHHHHHHHHHH	51.80	-
757	Phosphorylation	FQAAVPKTFQLQLLS HHHCCCCEEEEEEEC	15.56	20415495
764	Phosphorylation	TFQLQLLSPSSSVVP EEEEEEECCCCCCCC	31.18	29899451
766	Phosphorylation	QLQLLSPSSSVVPAF EEEEECCCCCCCCCC	31.69	20415495
767	Phosphorylation	LQLLSPSSSVVPAFN EEEECCCCCCCCCCC	30.45	20415495
768	Phosphorylation	QLLSPSSSVVPAFNT EEECCCCCCCCCCCC	31.32	20415495
775	Phosphorylation	SVVPAFNTGTITQVI CCCCCCCCCHHHHHH	29.28	20415495
777	Phosphorylation	VPAFNTGTITQVIKV CCCCCCCHHHHHHHH	20.86	20415495

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AP1G1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AP1G1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AP1G1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of AP1G1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.