NRK_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NRK_MOUSE
• UniProt AC: Q9R0G8
• Protein Name: Nik-related protein kinase
• Gene Name: Nrk
• Organism: Mus musculus (Mouse).
• Sequence Length: 1455
• Protein Description: May phosphorylate cofilin-1 and induce actin polymerization through this process, during the late stages of embryogenesis. Involved in the TNF-alpha-induced signaling pathway..
• Protein Sequence: MAGPGSWRDKEVTDLGQLPDPTGIFSLDKAIGLGTYGRIFLGIHEKTGSLVAVKVMSARKTPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVTFYGAFFKLNPPGHQHQLWMVMELCAAGSVTDVVRMTRNQSLKEDWIAYICREILQGLAHLHAHQVIHRDIKGQNVLLTHDAEVKIVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIHCDEDPRCSYDYRSDVWSVGITAIEMAEGAPPLCKLQPLEALCVILREAAPKVKSSGWSRKFQNFMENCMIKNFLFRPTSGNMLLHPFVHDIKNERRVVESLTKHLTGIIQKREKKGIPVAFEGEEAAKEQYITRRFRGPSCTPELLRVPTSSRCRPLRVLHGEPPQPRWLPDQEDPQDQELQQLQKAAGVFMPLHSQDNTSKLFPKQVEVAPYLRGAAQVVMPVLVQVEAPPQVSKAAQMLKSLPTQDNKATSPEVQAPVAEGQQAQHEALETEQPKDLDQVPEEFQGQDRAPEQPRQGQAAEQQQIHNPVPEQPPEEDREPEQAEVQEEAVEPPQAEIEDKEPEVVQVHAQVLLPLLSQNRHVLLPLHLDRQLLIPVGEQNEEVPRAQAWDLEASRAVGAVQALIEGLSRDLLRAPNAFVTKPLGPLQIFLENLSTDGFYTEPEPTQKKKSKVASLRKAIAKRLRPKRFRAKALWRLEDFEFSDVETSRRRRHRRWEDIFNQHEEQLRRVENDREDDSSDNDEVFHSIQAEVQIEPHAANPAGNEVHERSAPMPCNRNRTHRVKFSPSVGEEEPSLEEAQPQQQQQQPMNIRPRNCLNPQNFQAQSDSSSEEDSPVTRRKSQSSPPYSTIDQKLLIDIHVPDGFKVGKISPPVYLTNEWVGYNALSEIFWDDWIMPTRPARPPEEDGDYVELYDADANANGDEEVANGAYEDPRDGANGHDDMNNQLDQANGYEGHGAAGYNGGDVGGNHGAAFNGPRANYPRAGILKNGHNDGRALNRGAFGVFGDNAARAFHGAAGEAGAAFGNHGANRGNGRGNRNREANGRNEENGAFGRDQHVFPEFEHEESDRGTETSDSIALEITSFDGEQNSGRPVSSTTMGFPIGRSSPRGSDFGSDISYNSPILHVYEKDFSSEVYCGSLWGVNLLLGTQSHLYLMDRSGKAEIVKLIKRRPFRQIQVVEQLNLLITISGKKNRLRVYHLSWLRNKILNNDPKSKKRQKAMRKKEEACKAIDKLIGCEHFSVLQHEETTYIAVAVKSSIHLFAWAPKSFDENTAIKVFPTRDLKPLTVDLAVGSEKTLKIFFSSANGYHIIDAESEVMSEVTLPNNNVVILPDCLGLGVMLSLNAEAASEEANEQLLKKILDVWKDIPSSVAFECTKRITGWDQKAIEVRSLQSTILENELKRRSIKKLRFLCARGDKMFFASTLSNDHSRVYLMSLGKLEELHRSYAV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
199	Phosphorylation	KIVDFGVSAQVSRTN EEEEECCEEEEECCC	17.23	-
211	Phosphorylation	RTNGRRNSFIGTPYW CCCCCCCCCCCCCCE	19.21	25266776
336	Acetylation	HLTGIIQKREKKGIP HHHHHHHHHHHCCCC	52.71	15620357
353	Acetylation	FEGEEAAKEQYITRR ECCHHHHHHHHHHHC	53.01	15620365
709	Phosphorylation	RLEDFEFSDVETSRR EHHHCCCCCHHHHHH	33.28	28973931
792	Phosphorylation	RTHRVKFSPSVGEEE CCCCEEECCCCCCCC	15.56	26643407
794	Phosphorylation	HRVKFSPSVGEEEPS CCEEECCCCCCCCCC	41.37	21659605
801	Phosphorylation	SVGEEEPSLEEAQPQ CCCCCCCCHHHCCHH	52.25	21659605
832	Phosphorylation	PQNFQAQSDSSSEED HHHCCCCCCCCCCCC	42.34	25293948
834	Phosphorylation	NFQAQSDSSSEEDSP HCCCCCCCCCCCCCC	40.80	25293948
835	Phosphorylation	FQAQSDSSSEEDSPV CCCCCCCCCCCCCCC	46.92	25293948
836	Phosphorylation	QAQSDSSSEEDSPVT CCCCCCCCCCCCCCC	49.29	25293948
840	Phosphorylation	DSSSEEDSPVTRRKS CCCCCCCCCCCCCCC	25.26	25293948
843	Phosphorylation	SEEDSPVTRRKSQSS CCCCCCCCCCCCCCC	28.30	25293948
847	Phosphorylation	SPVTRRKSQSSPPYS CCCCCCCCCCCCCCC	33.22	26643407
849	Phosphorylation	VTRRKSQSSPPYSTI CCCCCCCCCCCCCCC	52.48	27087446
850	Phosphorylation	TRRKSQSSPPYSTID CCCCCCCCCCCCCCC	23.43	27087446
854	Phosphorylation	SQSSPPYSTIDQKLL CCCCCCCCCCCCEEE	25.35	21183079
1112	Phosphorylation	MGFPIGRSSPRGSDF ECCCCCCCCCCCCCC	39.21	21183079
1117	Phosphorylation	GRSSPRGSDFGSDIS CCCCCCCCCCCCCCC	30.92	21183079
1121	Phosphorylation	PRGSDFGSDISYNSP CCCCCCCCCCCCCCC	31.59	27087446
1124	Phosphorylation	SDFGSDISYNSPILH CCCCCCCCCCCCEEE	24.21	27087446
1125	Phosphorylation	DFGSDISYNSPILHV CCCCCCCCCCCEEEE	21.72	21183079
1165	Phosphorylation	HLYLMDRSGKAEIVK EEEEECCCCCHHHHH	40.14	21183079
1225	Acetylation	PKSKKRQKAMRKKEE HHHHHHHHHHHHHHH	48.46	6566007
1247	Phosphorylation	LIGCEHFSVLQHEET HHCCCCEEEECCCCC	24.67	28059163

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NRK_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NRK_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NRK_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of NRK_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.