PWP2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PWP2_MOUSE
• UniProt AC: Q8BU03
• Protein Name: Periodic tryptophan protein 2 homolog
• Gene Name: Pwp2
• Organism: Mus musculus (Mouse).
• Sequence Length: 919
• Subcellular Localization: Nucleus, nucleolus.
• Protein Sequence: MKFAYRFSNLLGTVYRCGNLNFTHDGNSVISPVGNRVTVFDLKNNRSNTLPLATKYNIKCVGLSPDGRLAIIVDEGGAALLVSLVCRSVLHHFHFKGSVHSVSFSPDGRKFVVTKGNIAQMYHAPGKKREFNAFVLDKTYFGPYDETTCIDWTDDSKCFVVGSKDMSTWVFGAERWDNLIYYALSGHKDAIVACFFESNSLDLYSLSQDGALCVWQCDTPPEGLRLKAPRGWKADILQREKEEEEEDEEEGDRETTIRGKTTPAEQERVGKVKYSRLAKYFLNKEGDFNNLTSAAYHKKTHLLVTGFASGIFHLHELPEFNLIHSLSISDQRVASVAINSSGDWIAFGCSGMGQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTLTEHSSGVTGVTFTTTGHVIVTSSLDGTVRAFDLHRYRNFRTFTSPRPTQFSCVAVDSSGEIVSAGAQDSFEIFVWSMQTGRLLDVLSGHEGPVSGLCFNPMKSILASASWDKTVRLWDMFDSWRTKETLTLTSDALAVTFRPDGAELAVATLNSQITFWDPENAVQVGSIEGRHDLKTGRKELDKITAKHSAKGKAFTTLCYSADGQSILAGGMSKFVCLYHVREQILVKRFELSCNLSLDAMEEFLNRRKMTEFGNLALIDQDAGEENGVAVPLPGVRKGDMSSRHFKPEIRVTSLRFSPTGRCWAATSTEGLLIFSLDAQMLFDPFELDTSVTPGRIREALRQREFTRAILMAFRLNEKKLAQEALEAVPQNEIEVVSTSLPELYVVKVLEFLAASFEESRHLEFYLIWTQKLLMSHGQRLKSRAGQLLPVVQFLQKGLQRHLDDVSKLCDWNRFNIQYVLAVSKQRGMKRTLEPVDTEEDSDASDEDSLHLLRAAGEEEEEEMLI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
55	Acetylation	NTLPLATKYNIKCVG CCCCEEEEECEEEEE	30.60	23806337
233	Ubiquitination	LKAPRGWKADILQRE CCCCCCHHHHHHHHH	38.72	-
255	Phosphorylation	EEEGDRETTIRGKTT HCCCCCCCCCCCCCC	28.54	-
256	Phosphorylation	EEGDRETTIRGKTTP CCCCCCCCCCCCCCH	12.15	-
260	Acetylation	RETTIRGKTTPAEQE CCCCCCCCCCHHHHH	39.10	23806337
650	Phosphorylation	FELSCNLSLDAMEEF EEEECCCCHHHHHHH	15.37	21183079
700	Acetylation	DMSSRHFKPEIRVTS CCCCCCCCCEEEEEE	35.30	22826441
850	Ubiquitination	PVVQFLQKGLQRHLD HHHHHHHHHHHHHHH	64.83	-
885	Phosphorylation	KQRGMKRTLEPVDTE HHCCCCCEECCCCCC	29.92	25619855
891	Phosphorylation	RTLEPVDTEEDSDAS CEECCCCCCCCCCCC	41.32	26824392
895	Phosphorylation	PVDTEEDSDASDEDS CCCCCCCCCCCCHHH	38.05	27087446
898	Phosphorylation	TEEDSDASDEDSLHL CCCCCCCCCHHHHHH	46.66	27087446
902	Phosphorylation	SDASDEDSLHLLRAA CCCCCHHHHHHHHHC	18.68	27087446

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PWP2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PWP2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PWP2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PWP2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-895; SER-898 ANDSER-902, AND MASS SPECTROMETRY.
PubMed: 17242355