dbPTM

COX6C_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	COX6C_MOUSE
UniProt AC	Q9CPQ1
Protein Name	Cytochrome c oxidase subunit 6C
Gene Name	Cox6c
Organism	Mus musculus (Mouse).
Sequence Length	76
Subcellular Localization	Mitochondrion inner membrane.
Protein Description	This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport..
Protein Sequence	MSSGALLPKPQMRGLLAKRLRVHIAGAFIVALGVAAAYKFGVAEPRKKAYAEFYRNYDSMKDFEEMRKAGIFQSAK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSSGALLPK ------CCCCCCCCC	37.16	20139300
3	Phosphorylation	-----MSSGALLPKP -----CCCCCCCCCH	27.13	27742792
9	Acetylation	SSGALLPKPQMRGLL CCCCCCCCHHHHHHH	48.10	24062335
48	Ubiquitination	GVAEPRKKAYAEFYR CCCCHHHHHHHHHHH	48.16	27667366
50	Phosphorylation	AEPRKKAYAEFYRNY CCHHHHHHHHHHHCC	18.62	25195567
61	Acetylation	YRNYDSMKDFEEMRK HHCCHHHHHHHHHHH	64.32	23864654
61	Ubiquitination	YRNYDSMKDFEEMRK HHCCHHHHHHHHHHH	64.32	-
61	Succinylation	YRNYDSMKDFEEMRK HHCCHHHHHHHHHHH	64.32	26388266
68	Ubiquitination	KDFEEMRKAGIFQSA HHHHHHHHHCCCCCC	50.05	27667366
68	Malonylation	KDFEEMRKAGIFQSA HHHHHHHHHCCCCCC	50.05	26320211
68	Acetylation	KDFEEMRKAGIFQSA HHHHHHHHHCCCCCC	50.05	24062335
74	Phosphorylation	RKAGIFQSAK----- HHHCCCCCCC-----	27.55	28066266
76	Acetylation	AGIFQSAK------- HCCCCCCC-------	67.15	23864654
76	Succinylation	AGIFQSAK------- HCCCCCCC-------	67.15	26388266

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of COX6C_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
61	K	Acetylation		-
Acetylation of Lys-61 is observed in liver mitochondria from fasted mice but not from fed mice.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of COX6C_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of COX6C_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of COX6C_MOUSE

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Substrate and functional diversity of lysine acetylation revealed bya proteomics survey."; Kim S.C., Sprung R., Chen Y., Xu Y., Ball H., Pei J., Cheng T.,Kho Y., Xiao H., Xiao L., Grishin N.V., White M., Yang X.-J., Zhao Y.; Mol. Cell 23:607-618(2006). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-61, AND MASS SPECTROMETRY.	16916647 [Abstract]