| UniProt ID | ZW10_MOUSE | |
|---|---|---|
| UniProt AC | O54692 | |
| Protein Name | Centromere/kinetochore protein zw10 homolog | |
| Gene Name | Zw10 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 779 | |
| Subcellular Localization |
Cytoplasm . Endoplasmic reticulum membrane Peripheral membrane protein . Chromosome, centromere, kinetochore . Cytoplasm, cytoskeleton, spindle . Dynamic pattern of localization during the cell cycle. In most cells at interphase, present diffusely |
|
| Protein Description | Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex. Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the interphase NRZ complex which is believed to play a role in SNARE assembly at the ER (By similarity).. | |
| Protein Sequence | MASFVTEVLAHSGSLEKEDLGTRISRLTRRVEEIKGEVCNMISKKYSEFLPTMQSAQALVTQVDTLSNDIDQLKSRIETEVCRDLHISTVEFTNLKQQLERDSVVLTLLKQLQEFSSAIEEYNSALAEKKYIPAARHLEEAQECLKLLKSRKCFDLKMLKSLSMELTVQKQNILYHLGEDWQKLVVWKFPPAKDTSSLESCLQTELHLCTEQPEKEDMTPLPSISSVLLAFSILGELPTKLKSFGQMLLKYILKPLVTCPSLHAVIERQPSSVSICFESLTTDLEHPSPPEAFAKIRLVLEVLQKQLLDLPLDADLEIGKVPGIVLAEMLGEGIWEDLSECLIRNCLVYSIPTNSSKLQEYEEIIQSTEEFEKFLKEMRFLKGDTTDLLKYARNINSHFANKKCQDVIVAARNLMTSEIHNTVKIGPDCKEALPDLPSPDADHKLQVQTVCKAQFTDAGNLEPETSLDPQSFSLPTCRISEAVKKLMELAYQTLLEATTSSDQCAVQLFYSVRNIFHLFHDVVPTYHKENLRKLPQLAAIHHNNCMYIAHHLLTLGHQFRLRLAPILCDGTTTFVDLVPGFRRLGTECFLAQMQAQKGELLERLSSARSFANMDDEENYSAASKAVRQVLHQLRRLGIVWQDVLPVNIYCKAMGTLLNTAIAEMMSRITALEDISTEDGDRLYSLCKTVMDEGPQVFAPLSDENKNKKYQEEVPVYVSKWMPFKELMIMLQASLQEIGDRWADGKGPLATAFPSSEVKALIRALFQNTERRAAALAKIK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MASFVTEVL ------CCHHHHHHH | 16.21 | - | |
| 3 | Phosphorylation | -----MASFVTEVLA -----CCHHHHHHHH | 20.96 | 28066266 | |
| 12 | Phosphorylation | VTEVLAHSGSLEKED HHHHHHHCCCCCHHH | 25.19 | 26643407 | |
| 14 | Phosphorylation | EVLAHSGSLEKEDLG HHHHHCCCCCHHHHH | 36.05 | 26824392 | |
| 22 | Phosphorylation | LEKEDLGTRISRLTR CCHHHHHHHHHHHHH | 31.93 | 25293948 | |
| 107 | Phosphorylation | ERDSVVLTLLKQLQE HHHHHHHHHHHHHHH | 20.59 | 21454597 | |
| 161 | Phosphorylation | FDLKMLKSLSMELTV CCHHHHHHHHCEEEE | 23.01 | 26643407 | |
| 163 | Phosphorylation | LKMLKSLSMELTVQK HHHHHHHHCEEEECH | 19.80 | 26643407 | |
| 361 | Phosphorylation | NSSKLQEYEEIIQST CHHHHHHHHHHHHCH | 13.10 | - | |
| 385 | Phosphorylation | MRFLKGDTTDLLKYA CHHHCCCHHHHHHHH | 30.77 | 28464351 | |
| 386 | Phosphorylation | RFLKGDTTDLLKYAR HHHCCCHHHHHHHHH | 29.41 | 28464351 | |
| 404 | Glutathionylation | SHFANKKCQDVIVAA HHHCCCCHHHHHHHH | 4.45 | 24333276 | |
| 438 | Phosphorylation | EALPDLPSPDADHKL HHCCCCCCCCCCCCH | 42.59 | 27087446 | |
| 449 | Phosphorylation | DHKLQVQTVCKAQFT CCCHHHHHEEEEEEC | 29.08 | 25159016 | |
| 466 | Phosphorylation | GNLEPETSLDPQSFS CCCCCCCCCCCCCCC | 29.16 | 22067460 | |
| 568 | Glutathionylation | LRLAPILCDGTTTFV HHCCEEECCCCCCHH | 4.73 | 24333276 | |
| 755 | Phosphorylation | LATAFPSSEVKALIR CCCCCCHHHHHHHHH | 46.80 | 22067460 | |
| 777 | Acetylation | RRAAALAKIK----- HHHHHHHHCC----- | 52.45 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ZW10_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ZW10_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ZW10_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| RINT1_HUMAN | RINT1 | physical | 20360068 | |
| KNTC1_HUMAN | KNTC1 | physical | 20360068 | |
| ZWILC_HUMAN | ZWILCH | physical | 20360068 | |
| NBAS_HUMAN | NBAS | physical | 20360068 | |
| CKAP5_HUMAN | CKAP5 | physical | 20360068 | |
| ZW10_HUMAN | ZW10 | physical | 20360068 | |
| CS025_HUMAN | C19orf25 | physical | 20360068 | |
| SCFD2_HUMAN | SCFD2 | physical | 20360068 | |
| AT2B1_HUMAN | ATP2B1 | physical | 26496610 | |
| SEC20_HUMAN | BNIP1 | physical | 26496610 | |
| RNF5_HUMAN | RNF5 | physical | 26496610 | |
| KNTC1_HUMAN | KNTC1 | physical | 26496610 | |
| SPTC1_HUMAN | SPTLC1 | physical | 26496610 | |
| RPC1_HUMAN | POLR3A | physical | 26496610 | |
| SCFD1_HUMAN | SCFD1 | physical | 26496610 | |
| RGAP1_HUMAN | RACGAP1 | physical | 26496610 | |
| NBAS_HUMAN | NBAS | physical | 26496610 | |
| STX18_HUMAN | STX18 | physical | 26496610 | |
| ZWILC_HUMAN | ZWILCH | physical | 26496610 | |
| USE1_HUMAN | USE1 | physical | 26496610 | |
| RINT1_HUMAN | RINT1 | physical | 26496610 | |
| CS025_HUMAN | C19orf25 | physical | 26496610 | |
| SCFD2_HUMAN | SCFD2 | physical | 26496610 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
