SCFD2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SCFD2_HUMAN
• UniProt AC: Q8WU76
• Protein Name: Sec1 family domain-containing protein 2
• Gene Name: SCFD2
• Organism: Homo sapiens (Human).
• Sequence Length: 684
• Protein Description: May be involved in protein transport..
• Protein Sequence: MSASGVLSFTQQGWEQVLAKVKRAVVYLDAACAESLHWGCGSTRLLEAVGGPDCHLREFEPDAIGGGAKQPKAVFVLSCLLKGRTVEILRDIICRSHFQYCVVVTTVSHAVHLTANHVPAAAAAEMEGQQPVFEQLEEKLCEWMGNMNYTAEVFHVPLLLAPVAPHFALTPAFASLFPLLPQDVHLLNSARPDKRKLGSLGDVDSTTLTPELLLQIRCLVSGLSSLCEHLGVREECFAVGSLSQVIAADLANYAPAKNRKKTAAGRASVVFVDRTLDLTGAVGHHGDNLVEKIISALPQLPGHTNDVMVNMIALTALHTEEENYNVVAPGCLSQSSDTTAKALWEALLNTKHKEAVMEVRRHLVEAASRENLPIKMSMGRVTPGQLMSYIQLFKNNLKALMNHCGLLQLGLATAQTLKHPQTAKWDNFLAFERLLLQSIGESAMSVVLNQLLPMIKPVTQRTNEDYSPEELLILLIYIYSVTGELTVDKDLCEAEEKVKKALAQVFCEESGLSPLLQKITDWDSSINLTFHKSKIAVDELFTSLRDIAGARSLLKQFKSVYVPGNHTHQASYKPLLKQVVEEIFHPERPDSVDIEHMSSGLTDLLKTGFSMFMKVSRPHPSDYPLLILFVVGGVTVSEVKMVKDLVASLKPGTQVIVLSTRLLKPLNIPELLFATDRLHPDLGF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
69	Ubiquitination	DAIGGGAKQPKAVFV CCCCCCCCCCCHHEE	71.10	21906983
69 (in isoform 2)	Ubiquitination	-	71.10	21890473
69 (in isoform 1)	Ubiquitination	-	71.10	21890473
69	Acetylation	DAIGGGAKQPKAVFV CCCCCCCCCCCHHEE	71.10	25953088
72	Ubiquitination	GGGAKQPKAVFVLSC CCCCCCCCHHEEEEH	55.47	22817900
82	Ubiquitination	FVLSCLLKGRTVEIL EEEEHHHCCCHHHHH	33.14	-
194	Ubiquitination	LNSARPDKRKLGSLG HHCCCCCCCCCCCCC	54.86	22817900
196	Ubiquitination	SARPDKRKLGSLGDV CCCCCCCCCCCCCCC	64.04	22817900
196 (in isoform 2)	Ubiquitination	-	64.04	21890473
196 (in isoform 1)	Ubiquitination	-	64.04	21890473
199	Phosphorylation	PDKRKLGSLGDVDST CCCCCCCCCCCCCCC	39.35	25693802
205	Phosphorylation	GSLGDVDSTTLTPEL CCCCCCCCCCCCHHH	24.12	25693802
206	Phosphorylation	SLGDVDSTTLTPELL CCCCCCCCCCCHHHH	22.74	25693802
207	Phosphorylation	LGDVDSTTLTPELLL CCCCCCCCCCHHHHH	32.36	25693802
257	Ubiquitination	LANYAPAKNRKKTAA HHHCCCCCCCCCCCC	57.11	-
335	Phosphorylation	APGCLSQSSDTTAKA CCCCCCCCCHHHHHH	27.14	-
336	Phosphorylation	PGCLSQSSDTTAKAL CCCCCCCCHHHHHHH	31.19	-
338	Phosphorylation	CLSQSSDTTAKALWE CCCCCCHHHHHHHHH	30.51	-
339	Phosphorylation	LSQSSDTTAKALWEA CCCCCHHHHHHHHHH	31.02	-
351	Ubiquitination	WEALLNTKHKEAVME HHHHHCCCHHHHHHH	52.16	-
353	Ubiquitination	ALLNTKHKEAVMEVR HHHCCCHHHHHHHHH	49.26	-
368	Phosphorylation	RHLVEAASRENLPIK HHHHHHHHHCCCCCE	47.37	21406692
375	Ubiquitination	SRENLPIKMSMGRVT HHCCCCCEEECCCCC	24.00	-
377	Phosphorylation	ENLPIKMSMGRVTPG CCCCCEEECCCCCHH	17.06	21406692
382	Phosphorylation	KMSMGRVTPGQLMSY EEECCCCCHHHHHHH	21.97	21406692
388	Phosphorylation	VTPGQLMSYIQLFKN CCHHHHHHHHHHHHH	27.89	25849741
389	Phosphorylation	TPGQLMSYIQLFKNN CHHHHHHHHHHHHHH	4.44	25849741
424 (in isoform 1)	Ubiquitination	-	59.47	21890473
424	Ubiquitination	LKHPQTAKWDNFLAF CCCCCCCCHHHHHHH	59.47	21890473
424 (in isoform 2)	Ubiquitination	-	59.47	21890473
500	Ubiquitination	EAEEKVKKALAQVFC HHHHHHHHHHHHHHH	52.17	29967540
534	Ubiquitination	NLTFHKSKIAVDELF CCEEECHHHHHHHHH	39.22	29967540
552	Phosphorylation	RDIAGARSLLKQFKS HHHHHHHHHHHHCCC	37.20	24719451
555	Ubiquitination	AGARSLLKQFKSVYV HHHHHHHHHCCCEEC	60.01	-
610	Phosphorylation	DLLKTGFSMFMKVSR HHHHHCCHHHCCCCC	16.68	28857561
619 (in isoform 2)	Ubiquitination	-	33.13	21890473
648	Phosphorylation	MVKDLVASLKPGTQV HHHHHHHCCCCCCEE	29.46	-
653	Phosphorylation	VASLKPGTQVIVLST HHCCCCCCEEEEEEC	28.34	-
664 (in isoform 1)	Ubiquitination	-	52.64	21890473
664	Ubiquitination	VLSTRLLKPLNIPEL EEECCCCCCCCHHHH	52.64	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SCFD2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SCFD2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SCFD2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NBAS_HUMAN	NBAS	physical	28514442
SEC20_HUMAN	BNIP1	physical	28514442
ZW10_HUMAN	ZW10	physical	28514442
CS025_HUMAN	C19orf25	physical	28514442
STX18_HUMAN	STX18	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.