USE1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: USE1_HUMAN
• UniProt AC: Q9NZ43
• Protein Name: Vesicle transport protein USE1
• Gene Name: USE1
• Organism: Homo sapiens (Human).
• Sequence Length: 259
• Subcellular Localization: Endoplasmic reticulum membrane ; Single-pass type IV membrane protein .
• Protein Description: SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER..
• Protein Sequence: MAASRLELNLVRLLSRCEAMAAEKRDPDEWRLEKYVGALEDMLQALKVHASKPASEVINEYSWKVDFLKGMLQAEKLTSSSEKALANQFLAPGRVPTTARERVPATKTVHLQSRARYTSEMRSELLGTDSAEPEMDVRKRTGVAGSQPVSEKQLAAELDLVLQRHQNLQEKLAEEMLGLARSLKTNTLAAQSVIKKDNQTLSHSLKMADQNLEKLKTESERLEQHTQKSVNWLLWAMLIIVCFIFISMILFIRIMPKLK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	LNLVRLLSRCEAMAA HHHHHHHHHHHHHHH	39.20	28857561
24	Ubiquitination	CEAMAAEKRDPDEWR HHHHHHHCCCCCHHH	58.33	29901268
34	Ubiquitination	PDEWRLEKYVGALED CCHHHHHHHHHHHHH	50.24	-
69	Ubiquitination	SWKVDFLKGMLQAEK HHHHHHHHHHHHHHH	42.12	29967540
78	Phosphorylation	MLQAEKLTSSSEKAL HHHHHHCCCHHHHHH	37.32	-
83	Ubiquitination	KLTSSSEKALANQFL HCCCHHHHHHHHHCC	51.12	29967540
97	Phosphorylation	LAPGRVPTTARERVP CCCCCCCCCHHHCCC	30.17	20068231
98	Phosphorylation	APGRVPTTARERVPA CCCCCCCCHHHCCCC	20.04	20068231
107	Ubiquitination	RERVPATKTVHLQSR HHCCCCCCEEHHHHH	51.13	29967540
117	Phosphorylation	HLQSRARYTSEMRSE HHHHHHHCCHHHHHH	17.40	29209046
118	Phosphorylation	LQSRARYTSEMRSEL HHHHHHCCHHHHHHH	16.80	29209046
119	Phosphorylation	QSRARYTSEMRSELL HHHHHCCHHHHHHHH	22.06	29209046
123	Phosphorylation	RYTSEMRSELLGTDS HCCHHHHHHHHCCCC	31.14	22210691
128	Phosphorylation	MRSELLGTDSAEPEM HHHHHHCCCCCCCCC	27.10	22210691
130	Phosphorylation	SELLGTDSAEPEMDV HHHHCCCCCCCCCCH	34.08	29209046
135	Sulfoxidation	TDSAEPEMDVRKRTG CCCCCCCCCHHHHHC	9.38	21406390
141	Phosphorylation	EMDVRKRTGVAGSQP CCCHHHHHCCCCCCC	38.76	28555341
146	Phosphorylation	KRTGVAGSQPVSEKQ HHHCCCCCCCCCHHH	22.90	25159151
150	Phosphorylation	VAGSQPVSEKQLAAE CCCCCCCCHHHHHHH	45.84	20363803
152 (in isoform 1)	Ubiquitination	-	43.01	21906983
152	Ubiquitination	GSQPVSEKQLAAELD CCCCCCHHHHHHHHH	43.01	2190698
154	Phosphorylation	QPVSEKQLAAELDLV CCCCHHHHHHHHHHH	7.85	24719451
171	Ubiquitination	RHQNLQEKLAEEMLG HHHHHHHHHHHHHHH	39.78	29967540
182	Phosphorylation	EMLGLARSLKTNTLA HHHHHHHHHHHCHHH	28.72	-
184	Ubiquitination	LGLARSLKTNTLAAQ HHHHHHHHHCHHHHH	40.76	29967540
187	Phosphorylation	ARSLKTNTLAAQSVI HHHHHHCHHHHHHHH	24.01	28555341
192	Phosphorylation	TNTLAAQSVIKKDNQ HCHHHHHHHHHHCCC	22.53	25159151
196	Ubiquitination	AAQSVIKKDNQTLSH HHHHHHHHCCCCHHH	51.27	29967540
200	Phosphorylation	VIKKDNQTLSHSLKM HHHHCCCCHHHHHHH	36.16	25262027
202	Phosphorylation	KKDNQTLSHSLKMAD HHCCCCHHHHHHHHH	17.89	25262027
204	Phosphorylation	DNQTLSHSLKMADQN CCCCHHHHHHHHHHH	26.72	25262027
206	Ubiquitination	QTLSHSLKMADQNLE CCHHHHHHHHHHHHH	34.75	30230243
214	Ubiquitination	MADQNLEKLKTESER HHHHHHHHHHHHHHH	59.45	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of USE1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of USE1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of USE1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
SEC20_HUMAN	BNIP1	physical	26186194
SNAA_HUMAN	NAPA	physical	26186194
STX18_HUMAN	STX18	physical	26186194
MGLL_HUMAN	MGLL	physical	26186194
SCFD2_HUMAN	SCFD2	physical	26186194
ZW10_HUMAN	ZW10	physical	26186194
STX5_HUMAN	STX5	physical	26186194
NBAS_HUMAN	NBAS	physical	26186194
RINT1_HUMAN	RINT1	physical	26186194
TYW5_HUMAN	TYW5	physical	26186194
SCFD1_HUMAN	SCFD1	physical	26186194
CS025_HUMAN	C19orf25	physical	26186194
SCFD2_HUMAN	SCFD2	physical	28514442
STX18_HUMAN	STX18	physical	28514442
NBAS_HUMAN	NBAS	physical	28514442
TYW5_HUMAN	TYW5	physical	28514442
MGLL_HUMAN	MGLL	physical	28514442
ZW10_HUMAN	ZW10	physical	28514442
STX5_HUMAN	STX5	physical	28514442
SEC20_HUMAN	BNIP1	physical	28514442
CS025_HUMAN	C19orf25	physical	28514442
SCFD1_HUMAN	SCFD1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.