MGLL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MGLL_HUMAN
• UniProt AC: Q99685
• Protein Name: Monoglyceride lipase {ECO:0000312|HGNC:HGNC:17038}
• Gene Name: MGLL {ECO:0000312|HGNC:HGNC:17038}
• Organism: Homo sapiens (Human).
• Sequence Length: 303
• Subcellular Localization: Cytoplasm, cytosol . Membrane ; Peripheral membrane protein .
• Protein Description: Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (By similarity). Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth. [PubMed: 20079333]
• Protein Sequence: MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLGHSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPIDSSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADRLCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTASPP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MPEESSPRRTPQS --CCCCCCCCCCCCC	26.21	21815630
9 (in isoform 2)	Phosphorylation	-	54.89	26852163
10	Phosphorylation	EESSPRRTPQSIPYQ CCCCCCCCCCCCCHH	27.27	26657352
10 (in isoform 2)	Phosphorylation	-	27.27	26852163
15 (in isoform 2)	Phosphorylation	-	26.44	22199227
16 (in isoform 2)	Phosphorylation	-	17.00	22199227
20	Phosphorylation	SIPYQDLPHLVNADG CCCHHHCCCCCCCCC	27.36	27251275
36	Ubiquitination	YLFCRYWKPTGTPKA EEEEEEECCCCCCCE	24.62	-
58	Nitrated tyrosine	AGEHSGRYEELARML CCCCCCHHHHHHHHH	19.79	-
58	Nitration	AGEHSGRYEELARML CCCCCCHHHHHHHHH	19.79	-
188	Ubiquitination	SSVLSRNKTEVDIYN HHHHCCCCCEEEEEC	44.97	-
189	Phosphorylation	SVLSRNKTEVDIYNS HHHCCCCCEEEEECC	44.80	23312004
196	Phosphorylation	TEVDIYNSDPLICRA CEEEEECCCCCHHHH	24.51	23312004
206	Phosphorylation	LICRAGLKVCFGIQL CHHHHCHHHHHHHHH	35.72	27251275
248	Phosphorylation	LCDSKGAYLLMELAK HCCCHHHHHHHHHHH	14.72	-
256	Phosphorylation	LLMELAKSQDKTLKI HHHHHHHCCCCEEEH	37.70	24719451
260	Phosphorylation	LAKSQDKTLKIYEGA HHHCCCCEEEHHHHH	41.39	28258704
266	Phosphorylation	KTLKIYEGAYHVLHK CEEEHHHHHHHHHHH	17.92	24719451
299	Phosphorylation	QRTATAGTASPP--- HCCCCCCCCCCC---	22.84	23403867
301	Phosphorylation	TATAGTASPP----- CCCCCCCCCC-----	37.23	20886841

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MGLL_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MGLL_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MGLL_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SCG1_HUMAN	CHGB	physical	16169070
HPCL1_HUMAN	HPCAL1	physical	26186194
MGLL_HUMAN	MGLL	physical	19957260
HPCL1_HUMAN	HPCAL1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.