PUR9_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PUR9_MOUSE
• UniProt AC: Q9CWJ9
• Protein Name: Bifunctional purine biosynthesis protein PURH
• Gene Name: Atic
• Organism: Mus musculus (Mouse).
• Sequence Length: 592
• Protein Description: Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis.; Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization..
• Protein Sequence: MAPSQLALFSVSDKTGLVEFARSLASLGLSLVASGGTAKAIRDAGLAVRDVSELTGFPEMLGGRVKTLHPAVHAGILARNIPEDAADMARLDFNLVRVVVCNLYPFVKTVASPDVTVEAAVEQIDIGGVTLLRAAAKNHARVTVVCEPEDYAGVAAEMHGSDSKDTSLETRRHLALKAFTHTAQYDEAISDYFRKQYSKGISQMPLRYGMNPHQTPAQLYTLKPKLPITVLNGAPGFINLCDALNAWQLVTELRGAVDIPAAASFKHVSPAGAAVGVPLSEDEARVCMVYDLYPTLTPLAVAYARARGADRMSSFGDFVALSDICDVPTAKIISREVSDGIVAPGYEEEALKILSKKKNGNYCVLQMDQSYKPDENEVRTLFGLRLSQKRNNGVVDKSLFSNIVTKNKDLPESALRDLIVATVAVKYTQSNSVCYAKDGQVIGIGAGQQSRIHCTRLAGDKANSWWLRHHPRVLSMKFKAGVKRAEISNAIDQYVTGTIGEGEDLVKWEALFEEVPELLTEAEKKEWVDKLSGVSVSSDAFFPFRDNVDRAKRSGVAYIVAPSGSTADKVVIEACDELGIVLAHTDLRLFHH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MAPSQLAL -------CCCCCEEE	12.81	-
4	Phosphorylation	----MAPSQLALFSV ----CCCCCEEEEEC	28.43	28464351
10	Phosphorylation	PSQLALFSVSDKTGL CCCEEEEECCCCCCH	22.89	24759943
14	Ubiquitination	ALFSVSDKTGLVEFA EEEECCCCCCHHHHH	36.67	22790023
23	Phosphorylation	GLVEFARSLASLGLS CHHHHHHHHHHHCCE	25.51	22871156
34	Phosphorylation	LGLSLVASGGTAKAI HCCEEHHCCHHHHHH	30.21	22871156
66	Ubiquitination	EMLGGRVKTLHPAVH HHHCCCCCCCCHHHH	43.97	22790023
101	S-nitrosylation	NLVRVVVCNLYPFVK CEEEEEEECCHHHCC	1.64	21278135
101	Glutathionylation	NLVRVVVCNLYPFVK CEEEEEEECCHHHCC	1.64	24333276
101	S-nitrosocysteine	NLVRVVVCNLYPFVK CEEEEEEECCHHHCC	1.64	-
104	Phosphorylation	RVVVCNLYPFVKTVA EEEEECCHHHCCCCC	4.80	28464351
109	Phosphorylation	NLYPFVKTVASPDVT CCHHHCCCCCCCCCC	18.92	26745281
112	Phosphorylation	PFVKTVASPDVTVEA HHCCCCCCCCCCHHH	19.80	26745281
116	Phosphorylation	TVASPDVTVEAAVEQ CCCCCCCCHHHHEEE	21.73	26745281
199	Acetylation	YFRKQYSKGISQMPL HHHHHHCCCCCCCCC	56.16	-
199	Malonylation	YFRKQYSKGISQMPL HHHHHHCCCCCCCCC	56.16	26320211
199	Ubiquitination	YFRKQYSKGISQMPL HHHHHHCCCCCCCCC	56.16	27667366
208	Phosphorylation	ISQMPLRYGMNPHQT CCCCCCCCCCCCCCC	28.54	29472430
215	Phosphorylation	YGMNPHQTPAQLYTL CCCCCCCCHHHEEEC	19.98	29472430
223	Acetylation	PAQLYTLKPKLPITV HHHEEECCCCCCEEE	32.10	22826441
223	Ubiquitination	PAQLYTLKPKLPITV HHHEEECCCCCCEEE	32.10	22790023
264	Phosphorylation	VDIPAAASFKHVSPA CCCCCHHCCCCCCCC	30.05	23140645
266	Acetylation	IPAAASFKHVSPAGA CCCHHCCCCCCCCCC	40.37	23806337
266	Malonylation	IPAAASFKHVSPAGA CCCHHCCCCCCCCCC	40.37	26320211
280	Phosphorylation	AAVGVPLSEDEARVC CEECCCCCHHHCEEE	36.61	26525534
287	Glutathionylation	SEDEARVCMVYDLYP CHHHCEEEEEECCCC	0.96	24333276
290	Phosphorylation	EARVCMVYDLYPTLT HCEEEEEECCCCCCH	3.55	22817900
293	Phosphorylation	VCMVYDLYPTLTPLA EEEEECCCCCCHHHH	7.41	22817900
313	Phosphorylation	ARGADRMSSFGDFVA HCCCCHHHCCCCEEH	24.33	24759943
314	Phosphorylation	RGADRMSSFGDFVAL CCCCHHHCCCCEEHH	24.73	24759943
322	Phosphorylation	FGDFVALSDICDVPT CCCEEHHHHHCCCCC	18.39	24759943
325	S-nitrosocysteine	FVALSDICDVPTAKI EEHHHHHCCCCCCEE	5.32	-
325	S-nitrosylation	FVALSDICDVPTAKI EEHHHHHCCCCCCEE	5.32	21278135
329	Phosphorylation	SDICDVPTAKIISRE HHHCCCCCCEEEEEE	40.19	24759943
352	Acetylation	GYEEEALKILSKKKN CCHHHHHHHHHCCCC	48.96	23236377
352	Ubiquitination	GYEEEALKILSKKKN CCHHHHHHHHHCCCC	48.96	22790023
363	S-nitrosocysteine	KKKNGNYCVLQMDQS CCCCCCEEEEEECCC	2.60	-
363	S-nitrosylation	KKKNGNYCVLQMDQS CCCCCCEEEEEECCC	2.60	20925432
387	Phosphorylation	TLFGLRLSQKRNNGV HHHHHHHHHHCCCCC	27.50	22817900
397	Ubiquitination	RNNGVVDKSLFSNIV CCCCCCCHHHHHCCC	37.13	22790023
406	Ubiquitination	LFSNIVTKNKDLPES HHHCCCCCCCCCCHH	51.62	-
406	Malonylation	LFSNIVTKNKDLPES HHHCCCCCCCCCCHH	51.62	26320211
430	Phosphorylation	VAVKYTQSNSVCYAK HEEEECCCCCEEEEE	24.23	22802335
432	Phosphorylation	VKYTQSNSVCYAKDG EEECCCCCEEEEECC	20.86	22802335
434	S-nitrosocysteine	YTQSNSVCYAKDGQV ECCCCCEEEEECCCE	2.47	-
434	S-nitrosylation	YTQSNSVCYAKDGQV ECCCCCEEEEECCCE	2.47	21278135
435	Phosphorylation	TQSNSVCYAKDGQVI CCCCCEEEEECCCEE	17.96	22802335
437	Acetylation	SNSVCYAKDGQVIGI CCCEEEEECCCEEEE	35.60	22826441
475	Phosphorylation	RHHPRVLSMKFKAGV HCCCCCEEEEECCCC	19.64	20139300
563	Phosphorylation	VAYIVAPSGSTADKV CEEEECCCCCCCCHH	35.32	23684622
565	Phosphorylation	YIVAPSGSTADKVVI EEECCCCCCCCHHHH	25.43	29472430
566	Phosphorylation	IVAPSGSTADKVVIE EECCCCCCCCHHHHH	42.26	28464351
575	Glutathionylation	DKVVIEACDELGIVL CHHHHHHHHHHCCEE	2.44	24333276

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PUR9_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PUR9_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PUR9_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PUR9_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.