SAFB1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SAFB1_MOUSE
• UniProt AC: D3YXK2
• Protein Name: Scaffold attachment factor B1
• Gene Name: Safb
• Organism: Mus musculus (Mouse).
• Sequence Length: 937
• Subcellular Localization: Nucleus.
• Protein Description: Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing. Can function as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription. Can inhibit cell proliferation. When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter..
• Protein Sequence: MAETLSGLGDASAAGAAAVSSAASETGTRRLSDLRVIDLRAELKKRNLDSSGNKSVLMERLKKAIEDEGGNPDEIEVTSECNKKMPKRPSKGRKPEDEGVEDNGLEENSGDGQEDVETSLENLQDMDMMDISVLDEADIDNGSVADCVEEEEEATLPEGLADSTELVEGDLKGLPEQLQEHAIDDKDTVNNVDTSSSDFTMLQEMEEASLEPENEKILDILGETCKSEPVKEEGSELEQPFAQATSSVGPDRKLAEEEDLFESCGHPEEEEEEEEEDQEEEQEEEGDLALASSSKSESPSTRCQWSEADAPLAVVKREPADAPGGGTGMDREPVGLEEPVEQSSTAAQLPEATSQELVRAPTAALSPEPQDSKEDVKKFAFDACNDVPAPPKESSASEGADQKMSSVEEDSDTKRLSREEKGRSSCGRNFWVSGLSSTTRATDLKNLFSRYGKVVGAKVVTNARSPGARCYGFVTMSTAEEATKCISHLHKTELHGKMISVEKAKSEPTGKRVPDRRDGDSKKEKASTSDRSANLKREEKGERKDDAKKTDDGSTEKSKDADDQKPGPSERSRTTKSGSRGTERTVVMDKSKGVPVISVKTSGSKERASKSQDRKSASREKRSVVSFDKVKESRKSRDSESRRERERSEREQRLQAQWEREERERLEIARERLAFHRHRLERERMERERLERERMHVEQERRREQERIHREREELRRQQELRYEQERRPAVRRPYEVDGRRDDAYWPEAKRAALDDRYHSDFSRQDRFHDFDHRDRGRYPNHSVDRREGSRSMMGDREGQHYPERHGGPERHGRDSRDGWGYGSNKRLSEGRGLPPPPRRDWGEHGRRLEDDRAWQGTADGGMMERDHKRWQGGERSMSGHSGPGHMMNRGGMSGRGSFAPGGASRGHVIPRGGMQAGFGGQSRGSRPSDARFTRRY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAETLSGLG ------CCCCCCCCC	20.62	-
4	Phosphorylation	----MAETLSGLGDA ----CCCCCCCCCCH	19.38	25619855
6	Phosphorylation	--MAETLSGLGDASA --CCCCCCCCCCHHH	39.12	25619855
12	Phosphorylation	LSGLGDASAAGAAAV CCCCCCHHHHHHHHH	24.32	25619855
20	Phosphorylation	AAGAAAVSSAASETG HHHHHHHHHHHHHHC	14.99	25619855
21	Phosphorylation	AGAAAVSSAASETGT HHHHHHHHHHHHHCC	22.66	25619855
24	Phosphorylation	AAVSSAASETGTRRL HHHHHHHHHHCCCCH	35.09	26824392
26	Phosphorylation	VSSAASETGTRRLSD HHHHHHHHCCCCHHH	41.16	25619855
28	Phosphorylation	SAASETGTRRLSDLR HHHHHHCCCCHHHCE	21.75	25619855
32	Phosphorylation	ETGTRRLSDLRVIDL HHCCCCHHHCEEEEH	32.56	24704852
54	Acetylation	NLDSSGNKSVLMERL CCCCCCCHHHHHHHH	45.53	22826441
55	Phosphorylation	LDSSGNKSVLMERLK CCCCCCHHHHHHHHH	25.20	25521595
78	Phosphorylation	NPDEIEVTSECNKKM CCCCCEECHHHHCCC	13.15	29899451
79	Phosphorylation	PDEIEVTSECNKKMP CCCCEECHHHHCCCC	45.38	29899451
188	Phosphorylation	HAIDDKDTVNNVDTS HCCCCCHHCCCCCCC	30.76	25367039
194	Phosphorylation	DTVNNVDTSSSDFTM HHCCCCCCCCCCCHH	26.65	27180971
195	Phosphorylation	TVNNVDTSSSDFTML HCCCCCCCCCCCHHH	24.31	24925903
196	Phosphorylation	VNNVDTSSSDFTMLQ CCCCCCCCCCCHHHH	35.70	24925903
197	Phosphorylation	NNVDTSSSDFTMLQE CCCCCCCCCCHHHHH	36.19	25521595
200	Phosphorylation	DTSSSDFTMLQEMEE CCCCCCCHHHHHHHH	23.20	24453211
209	Phosphorylation	LQEMEEASLEPENEK HHHHHHHCCCCCCHH	36.22	24925903
224	Phosphorylation	ILDILGETCKSEPVK HHHHHHHHHCCCCCC	24.36	30352176
227	Phosphorylation	ILGETCKSEPVKEEG HHHHHHCCCCCCCCC	49.64	27087446
235	Phosphorylation	EPVKEEGSELEQPFA CCCCCCCCCCCCHHH	42.14	25521595
245	Phosphorylation	EQPFAQATSSVGPDR CCHHHHHHCCCCCCH	14.95	25521595
246	Phosphorylation	QPFAQATSSVGPDRK CHHHHHHCCCCCCHH	26.49	25159016
247	Phosphorylation	PFAQATSSVGPDRKL HHHHHHCCCCCCHHH	27.09	25521595
263	Phosphorylation	EEEDLFESCGHPEEE HHHHHHHHCCCCHHH	20.33	19060867
292	Phosphorylation	EGDLALASSSKSESP HCHHHHHCCCCCCCC	35.67	22668510
294	Phosphorylation	DLALASSSKSESPST HHHHHCCCCCCCCCC	37.39	22668510
296	Phosphorylation	ALASSSKSESPSTRC HHHCCCCCCCCCCCC	45.30	24453211
298	Phosphorylation	ASSSKSESPSTRCQW HCCCCCCCCCCCCCC	31.10	27818261
300	Phosphorylation	SSKSESPSTRCQWSE CCCCCCCCCCCCCCC	37.45	26745281
301	Phosphorylation	SKSESPSTRCQWSEA CCCCCCCCCCCCCCC	38.56	24453211
306	Phosphorylation	PSTRCQWSEADAPLA CCCCCCCCCCCCCEE	9.31	25521595
316	Acetylation	DAPLAVVKREPADAP CCCEEEEECCCCCCC	44.43	22826441
353	Phosphorylation	AAQLPEATSQELVRA HHHCCCCCHHHHHHC	29.31	30387612
354	Phosphorylation	AQLPEATSQELVRAP HHCCCCCHHHHHHCC	28.80	17525332
362	Phosphorylation	QELVRAPTAALSPEP HHHHHCCCHHCCCCC	24.47	25521595
366	Phosphorylation	RAPTAALSPEPQDSK HCCCHHCCCCCCCCH	23.61	24925903
372	Phosphorylation	LSPEPQDSKEDVKKF CCCCCCCCHHHHHHH	32.47	24925903
378	Acetylation	DSKEDVKKFAFDACN CCHHHHHHHHHHHHC	41.60	-
394	Phosphorylation	VPAPPKESSASEGAD CCCCCCCCCCCCCCC	37.01	26643407
395	Phosphorylation	PAPPKESSASEGADQ CCCCCCCCCCCCCCH	36.58	27087446
397	Phosphorylation	PPKESSASEGADQKM CCCCCCCCCCCCHHH	38.21	27087446
405	Phosphorylation	EGADQKMSSVEEDSD CCCCHHHHCCCCCHH	37.96	26643407
406	Phosphorylation	GADQKMSSVEEDSDT CCCHHHHCCCCCHHH	30.01	26525534
411	Phosphorylation	MSSVEEDSDTKRLSR HHCCCCCHHHHCCCH	50.92	26643407
413	Phosphorylation	SVEEDSDTKRLSREE CCCCCHHHHCCCHHH	23.24	26643407
424	Phosphorylation	SREEKGRSSCGRNFW CHHHHCCCCCCCCCC	38.35	27600695
425	Phosphorylation	REEKGRSSCGRNFWV HHHHCCCCCCCCCCC	21.16	27600695
437	Phosphorylation	FWVSGLSSTTRATDL CCCCCCCCCCCHHHH	38.55	-
445	Ubiquitination	TTRATDLKNLFSRYG CCCHHHHHHHHHHHC	55.18	22790023
458	Acetylation	YGKVVGAKVVTNARS HCCEECCEEEECCCC	31.17	22826441
458	Malonylation	YGKVVGAKVVTNARS HCCEECCEEEECCCC	31.17	26320211
458	Ubiquitination	YGKVVGAKVVTNARS HCCEECCEEEECCCC	31.17	-
461	Phosphorylation	VVGAKVVTNARSPGA EECCEEEECCCCCCC	26.58	27087446
465	Phosphorylation	KVVTNARSPGARCYG EEEECCCCCCCEEEE	25.85	25521595
471	Phosphorylation	RSPGARCYGFVTMST CCCCCEEEEEEECCC	14.19	25293948
475	Phosphorylation	ARCYGFVTMSTAEEA CEEEEEEECCCHHHH	11.80	25293948
477	Phosphorylation	CYGFVTMSTAEEATK EEEEEECCCHHHHHH	18.33	25293948
478	Phosphorylation	YGFVTMSTAEEATKC EEEEECCCHHHHHHH	27.54	25293948
483	Phosphorylation	MSTAEEATKCISHLH CCCHHHHHHHHHHHH	29.72	25293948
497	Acetylation	HKTELHGKMISVEKA HHHHHCCEEEEHHHH	23.47	23806337
506	Phosphorylation	ISVEKAKSEPTGKRV EEHHHHCCCCCCCCC	54.38	20531401
523	Ubiquitination	RRDGDSKKEKASTSD CCCCCCHHHHCCCCC	69.29	-
525	Ubiquitination	DGDSKKEKASTSDRS CCCCHHHHCCCCCHH	57.42	-
536	Ubiquitination	SDRSANLKREEKGER CCHHHHHHHHHHCCC	58.53	-
559	Acetylation	DGSTEKSKDADDQKP CCCCCCCCCCCCCCC	68.92	19846611
574	Phosphorylation	GPSERSRTTKSGSRG CCCCCCCCCCCCCCC	39.56	28285833
575	Phosphorylation	PSERSRTTKSGSRGT CCCCCCCCCCCCCCC	23.31	20531401
577	Phosphorylation	ERSRTTKSGSRGTER CCCCCCCCCCCCCEE	39.65	25266776
579	Phosphorylation	SRTTKSGSRGTERTV CCCCCCCCCCCEEEE	34.33	25266776
582	Phosphorylation	TKSGSRGTERTVVMD CCCCCCCCEEEEEEE	22.60	26643407
585	Phosphorylation	GSRGTERTVVMDKSK CCCCCEEEEEEECCC	15.95	23375375
598	Phosphorylation	SKGVPVISVKTSGSK CCCCEEEEEECCCCH	20.14	28066266
601	Phosphorylation	VPVISVKTSGSKERA CEEEEEECCCCHHHH	35.84	29514104
602	Phosphorylation	PVISVKTSGSKERAS EEEEEECCCCHHHHC	35.04	27600695
604	Phosphorylation	ISVKTSGSKERASKS EEEECCCCHHHHCCC	30.98	29514104
609	Phosphorylation	SGSKERASKSQDRKS CCCHHHHCCCCCHHH	38.78	19367708
610	Ubiquitination	GSKERASKSQDRKSA CCHHHHCCCCCHHHH	51.67	-
611	Phosphorylation	SKERASKSQDRKSAS CHHHHCCCCCHHHHH	34.51	26824392
616	Phosphorylation	SKSQDRKSASREKRS CCCCCHHHHHHHHHH	32.16	23375375
618	Phosphorylation	SQDRKSASREKRSVV CCCHHHHHHHHHHHC	48.33	23375375
621	Ubiquitination	RKSASREKRSVVSFD HHHHHHHHHHHCCHH	49.19	-
623	Phosphorylation	SASREKRSVVSFDKV HHHHHHHHHCCHHHH	37.63	25521595
626	Phosphorylation	REKRSVVSFDKVKES HHHHHHCCHHHHHHH	26.10	26824392
629	Acetylation	RSVVSFDKVKESRKS HHHCCHHHHHHHHHC	53.87	23806337
636	Phosphorylation	KVKESRKSRDSESRR HHHHHHHCCCHHHHH	39.96	20415495
639	Phosphorylation	ESRKSRDSESRRERE HHHHCCCHHHHHHHH	36.04	20415495
641	Phosphorylation	RKSRDSESRRERERS HHCCCHHHHHHHHHH	40.36	20415495
648	Phosphorylation	SRRERERSEREQRLQ HHHHHHHHHHHHHHH	35.93	23684622
745	Phosphorylation	DGRRDDAYWPEAKRA CCCCCCCCCHHHHHH	28.61	-
783	Phosphorylation	RGRYPNHSVDRREGS CCCCCCCCCCCCCCC	32.14	29899451
816	Phosphorylation	PERHGRDSRDGWGYG CCCCCCCCCCCCCCC	30.80	29899451
829	Phosphorylation	YGSNKRLSEGRGLPP CCCCCCCCCCCCCCC	41.88	26824392
832	Methylation	NKRLSEGRGLPPPPR CCCCCCCCCCCCCCC	39.15	24129315
839	Methylation	RGLPPPPRRDWGEHG CCCCCCCCCCCHHHC	55.77	30989289
877	Phosphorylation	RWQGGERSMSGHSGP CCCCCCCCCCCCCCC	17.01	29895711
882	Phosphorylation	ERSMSGHSGPGHMMN CCCCCCCCCCCCCCC	50.65	29895711
890	Asymmetric dimethylarginine	GPGHMMNRGGMSGRG CCCCCCCCCCCCCCC	25.75	-
890	Methylation	GPGHMMNRGGMSGRG CCCCCCCCCCCCCCC	25.75	24129315
896	Asymmetric dimethylarginine	NRGGMSGRGSFAPGG CCCCCCCCCCCCCCC	30.21	-
896	Methylation	NRGGMSGRGSFAPGG CCCCCCCCCCCCCCC	30.21	24129315
906	Asymmetric dimethylarginine	FAPGGASRGHVIPRG CCCCCCCCCCEECCC	38.41	-
906	Methylation	FAPGGASRGHVIPRG CCCCCCCCCCEECCC	38.41	24129315
912	Asymmetric dimethylarginine	SRGHVIPRGGMQAGF CCCCEECCCCCCCCC	43.08	-
912	Methylation	SRGHVIPRGGMQAGF CCCCEECCCCCCCCC	43.08	24129315

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
366	S	Phosphorylation	Kinase	MAPK1	P63085	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SAFB1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SAFB1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SAFB1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.