GNL3L_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GNL3L_MOUSE
• UniProt AC: Q6PGG6
• Protein Name: Guanine nucleotide-binding protein-like 3-like protein
• Gene Name: Gnl3l
• Organism: Mus musculus (Mouse).
• Sequence Length: 577
• Subcellular Localization: Nucleus, nucleolus .
• Protein Description: Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP (By similarity)..
• Protein Sequence: MMKIRHKNKKPGKGSKGCKKPARQNGKKVTSRPSSAPQIVHGNDHASREAELKKKRVEEMREKQQVAREQERQRHRTMESYCQDVLKRQQEFEQKEEVLQELNMFPQLDDEATRKAYYKEFRKVVEYSDVILEVLDARDPLGCRCFQMEETVLRAEGNKKLVLVLNKIDLVPKEIVEKWLEYLLNELPTVAFKASTQHHQVKNLTRCKVPVDQASESLLKSRACFGAENLMRVLGNYCRLGEVRGHIRVGVVGLPNVGKSSLINSLKRSRACSVGAVPGVTKFMQEVYLDKFIRLLDAPGIVPGPNSEVGTILRNCIHVQKLADPVTPVETILQRCNLEEISSYYGVSGFQTTEHFLTAVAHRLGKKKKGGVYSQEQAAKAVLADWVSGKISFYTLPPPTHTLPTHLSAEIVKEMTEVFDIEDTEHANEDTMECLAVGESDELLGDMDPQEMEVRWLHSPLVKIADAIENRSTVYKIGNLTGYCTKPNRNQMGWPKRNVDHHCPQNNRVVEVSSVDRRPMLQRILETDPLQQGQALASALKNKKKLQKRSDKIATKLSDSMMSMLDLSGNSDDCAGD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
34	Phosphorylation	KKVTSRPSSAPQIVH CCCCCCCCCCCCCCC	37.71	28066266
35	Phosphorylation	KVTSRPSSAPQIVHG CCCCCCCCCCCCCCC	46.80	28066266
77	Phosphorylation	QERQRHRTMESYCQD HHHHHHHHHHHHHHH	21.11	-
159	Acetylation	VLRAEGNKKLVLVLN EEECCCCEEEEEEEE	59.34	23806337
160	Acetylation	LRAEGNKKLVLVLNK EECCCCEEEEEEEEC	48.07	23806337
215	Phosphorylation	KVPVDQASESLLKSR CCCHHHHHHHHHHHH	23.29	25293948
217	Phosphorylation	PVDQASESLLKSRAC CHHHHHHHHHHHHHC	36.18	25293948
221	Phosphorylation	ASESLLKSRACFGAE HHHHHHHHHHCCCHH	25.69	25293948
265	Phosphorylation	GKSSLINSLKRSRAC CHHHHHHHHHHHCCC	28.42	29514104
281	Phosphorylation	VGAVPGVTKFMQEVY CCCCCCHHHHHHHHH	25.20	24719451
459	Phosphorylation	MEVRWLHSPLVKIAD CHHHHHHCCHHHHHH	20.12	26745281
486	Ubiquitination	NLTGYCTKPNRNQMG CCEEECCCCCCCCCC	36.41	-
513	Phosphorylation	NNRVVEVSSVDRRPM CCEEEEEEEECCCHH	15.90	28066266
514	Phosphorylation	NRVVEVSSVDRRPML CEEEEEEEECCCHHH	32.96	28066266
538	Phosphorylation	QQGQALASALKNKKK HHHHHHHHHHHCHHH	34.68	28066266
568	Phosphorylation	MMSMLDLSGNSDDCA HHHHHHCCCCCCCCC	35.28	24224561
571	Phosphorylation	MLDLSGNSDDCAGD- HHHCCCCCCCCCCC-	38.05	24224561

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GNL3L_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GNL3L_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GNL3L_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of GNL3L_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.