| UniProt ID | FBX30_MOUSE | |
|---|---|---|
| UniProt AC | Q8BJL1 | |
| Protein Name | F-box only protein 30 | |
| Gene Name | Fbxo30 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 746 | |
| Subcellular Localization | ||
| Protein Description | Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Required for muscle atrophy following denervation.. | |
| Protein Sequence | MEEEVQQHSHCMNCVSRRCMTRPEPGVSCDLIGCPLVCGAVFHSCKADEHRLLCPFERVACLNRNFGCPFTLARNKVAEHLEMCPASVVCCTMEWNRWPVSYSDRKSYESLSRDVDEVAQLDMALALQDQRMLLESLKVATMMSKATDKISEPREQISVKSSVQEIPRTNGLVSVDEESYGALYQATVETTRSLAAALDILNSATRDIGMLNTSLHATANEMDEENNKESFQDKNLKDQDHLDEGEIGAVGGVDYSGTSQNAQAEQNGSSDLLCDLNPSSNGTSALCNGFPLEKMCIQVKGQDQNFHGDSTESNITNGDCVEADGTSEPSSSLVVPEQLREISPFSALPDSTFQQILMPDEDDEKDLCWKKVDLGDLKDVNGSPFSHAPSFKFLSNSWYIPKEDKAVDTSDLEVAEDPMGLQGIDLITAALLFCLGDSPGGRGISDSRMTDVYHVDFGTQTFSLPSAILATNTMVGEIASASACDHANPQLSNPSPFQTLGLDLVLECVARYQPKQRSMFTFVCGQLFRRKEFSSHFKNVHGDIHAGLNGWMEQRCPLAYYGCTYSQRRFCPSTQGAKIIHDRHLRSFGVQPCVSTVLEEPSRNCVLGLRSDHLSSLPFEVLQHIAGFLDGFSLCQLACVSRLMRDVCGSLLQSRGMVILQWGKKKYPEGNSSWQIKEKVWRFSTAFCSVNDWKFADILSMADHLKNCSYNVIEKREEAIPLPCMCVTRELTKEGRSLRSVLKPVL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 107 | Phosphorylation | VSYSDRKSYESLSRD CCHHHHHCHHHHCCC | 34.72 | 28973931 | |
| 160 | Ubiquitination | PREQISVKSSVQEIP CHHHCCCHHHCEECC | 30.17 | 22790023 | |
| 193 | Phosphorylation | ATVETTRSLAAALDI HHHHHHHHHHHHHHH | 21.92 | 22817900 | |
| 214 | Phosphorylation | DIGMLNTSLHATANE CHHCHHHHHHHHHHH | 19.65 | 25338131 | |
| 343 | Phosphorylation | PEQLREISPFSALPD HHHHHHCCCCCCCCC | 18.35 | 26824392 | |
| 371 | Ubiquitination | EKDLCWKKVDLGDLK CCCCCCEEEECCCCC | 19.24 | 22790023 | |
| 383 | Phosphorylation | DLKDVNGSPFSHAPS CCCCCCCCCCCCCCC | 19.98 | 27087446 | |
| 386 | Phosphorylation | DVNGSPFSHAPSFKF CCCCCCCCCCCCEEE | 23.32 | 26745281 | |
| 390 | Phosphorylation | SPFSHAPSFKFLSNS CCCCCCCCEEEECCC | 41.68 | 30352176 | |
| 395 | Phosphorylation | APSFKFLSNSWYIPK CCCEEEECCCEECCC | 31.76 | 22006019 | |
| 397 | Phosphorylation | SFKFLSNSWYIPKED CEEEECCCEECCCCC | 20.20 | 22006019 | |
| 471 | Phosphorylation | LPSAILATNTMVGEI CCCEECCCCCCHHHH | 27.98 | - | |
| 473 | Phosphorylation | SAILATNTMVGEIAS CEECCCCCCHHHHHC | 14.63 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of FBX30_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of FBX30_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of FBX30_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of FBX30_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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