GDF3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GDF3_MOUSE
• UniProt AC: Q07104
• Protein Name: Growth/differentiation factor 3
• Gene Name: Gdf3
• Organism: Mus musculus (Mouse).
• Sequence Length: 366
• Subcellular Localization: Secreted . Cytoplasm . Mainly accumulated in the cytoplasm.
• Protein Description: Growth factor involved in early embryonic development and adipose-tissue homeostasis. During embryogenesis controls formation of anterior visceral endoderm and mesoderm and the establishment of anterior-posterior identity through a receptor complex comprising the receptor ACVR1B and the coreceptor TDGF1/Cripto. [PubMed: 16368929]
• Protein Sequence: MQPYQRLLALGFLLLTLPWGQTSEFQDSDLLQFLGLEKAPSPHRFQPVPRVLRKIIRAREAAAASGASQDLCYVKELGVRGNLLQLLPDQGFFLNTQKPFQDGSCLQKVLYFNLSAIKEKAKLTMAQLTLDLGPRSYYNLRPELVVALSVVQDRGVWGRSHPKVGRLLFLRSVPGPQGQLQFNLQGALKDWSSNRLKNLDLHLEILVKEDRYSRVTVQPENPCDRLLRSLHASLLVVTLNPKHCHPSSRKRRAAISVPKGFCRNFCHRHQLFINFQDLGWHKWVIAPKGFMANYCHGECPFSMTTYLNSSNYAFMQALMHMADPKVPKAVCVPTKLSPISMLYQDSDKNVILRHYEDMVVDECGCG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
38	Ubiquitination	LQFLGLEKAPSPHRF HHHCCCCCCCCCCCC	71.31	-
113	N-linked_Glycosylation	LQKVLYFNLSAIKEK HHHHHHCCHHHHHHH	21.38	-
248	Phosphorylation	PKHCHPSSRKRRAAI HHCCCCCHHHHCEEE	46.39	24719451
256	Phosphorylation	RKRRAAISVPKGFCR HHHCEEEECCCCHHH	27.86	24719451
308	N-linked_Glycosylation	FSMTTYLNSSNYAFM CCCEECCCCCCHHHH	32.74	-
334	Phosphorylation	PKAVCVPTKLSPISM CCEEEECCCCCCCEE	24.99	-
337	Phosphorylation	VCVPTKLSPISMLYQ EEECCCCCCCEEEEE	23.03	27357545
343	Phosphorylation	LSPISMLYQDSDKNV CCCCEEEEECCCCCE	11.13	27357545
346	Phosphorylation	ISMLYQDSDKNVILR CEEEEECCCCCEEEH	34.65	27357545

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GDF3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GDF3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GDF3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of GDF3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.