| UniProt ID | RFOX2_MOUSE | |
|---|---|---|
| UniProt AC | Q8BP71 | |
| Protein Name | RNA binding protein fox-1 homolog 2 | |
| Gene Name | Rbfox2 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 449 | |
| Subcellular Localization | Nucleus. Cytoplasm. | |
| Protein Description | RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Prevents binding of U2AF2 to the 3'-splice site. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis. Seems to act as a coregulatory factor of ER-alpha (By similarity).. | |
| Protein Sequence | MAEGGQAQQQPPQLGPGAAARGMKRESEVELPVPGAGADGPEPGLSKRPRTEEAADGGMQNEPLTPGYHGFPARDGQGNQEPTTTPDAMVQPFTTIPFPPPPQNGIPTEYGVPHTQDYAGQTSEHNLTLYGSTQPHGEQSSNSPSNQNGSLTQTEGGAQTDGQQSQTQSSENSESKSTPKRLHVSNIPFRFRDPDLRQMFGQFGKILDVEIIFNERGSKGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTNKKMVTPYANGWKLSPVVGAVYGPELYAASSFQADVSLGNEAAVPLSGRGGINTYIPLISLPLVPGFPYPTAATTAAAFRGAHLRGRGRTVYGAVRAVPPTAIPAYPGVVYQDGFYGADLYGGYAAYRYAQPATATAATAAAAAAAAYSDGYGRVYTADPYHALAPAASYGVGAVASLYRGGYSRFAPY | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 21 | Methylation | LGPGAAARGMKRESE CCCCHHHCCCCCCCE | 40.80 | 58859243 | |
| 27 | Phosphorylation | ARGMKRESEVELPVP HCCCCCCCEEECCCC | 51.48 | 28066266 | |
| 51 | Phosphorylation | GLSKRPRTEEAADGG CCCCCCCCHHCCCCC | 40.64 | 25777480 | |
| 65 | Phosphorylation | GMQNEPLTPGYHGFP CCCCCCCCCCCCCCC | 25.94 | 22028470 | |
| 68 | Phosphorylation | NEPLTPGYHGFPARD CCCCCCCCCCCCCCC | 10.44 | 25777480 | |
| 149 (in isoform 4) | Phosphorylation | - | 17.80 | - | |
| 155 (in isoform 4) | Phosphorylation | - | 45.90 | - | |
| 236 (in isoform 4) | Methylation | - | 42.34 | 24129315 | |
| 238 | Ubiquitination | DADRAREKLHGTVVE CHHHHHHHHCCEEEE | 39.98 | - | |
| 241 (in isoform 4) | Methylation | - | 30.55 | 24129315 | |
| 248 | Ubiquitination | GTVVEGRKIEVNNAT CEEEECCEEEECCCE | 54.82 | - | |
| 268 (in isoform 8) | Methylation | - | 11.88 | 24129315 | |
| 268 (in isoform 7) | Methylation | - | 11.88 | 24129315 | |
| 268 (in isoform 6) | Methylation | - | 11.88 | 24129315 | |
| 273 (in isoform 8) | Methylation | - | 40.25 | 24129315 | |
| 273 (in isoform 7) | Methylation | - | 40.25 | 24129315 | |
| 273 (in isoform 6) | Methylation | - | 40.25 | 24129315 | |
| 285 (in isoform 4) | Methylation | - | 50.48 | 24129315 | |
| 285 (in isoform 4) | Dimethylation | - | 50.48 | - | |
| 317 (in isoform 8) | Methylation | - | 17.15 | 24129315 | |
| 318 (in isoform 2) | Methylation | - | 2.77 | 24129315 | |
| 323 (in isoform 2) | Methylation | - | 9.84 | 24129315 | |
| 336 (in isoform 5) | Methylation | - | 7.76 | 24129315 | |
| 340 | Methylation | ATTAAAFRGAHLRGR HHHHHHHCCHHHCCC | 36.34 | 24129315 | |
| 341 (in isoform 5) | Methylation | - | 15.76 | 24129315 | |
| 345 | Methylation | AFRGAHLRGRGRTVY HHCCHHHCCCCCEEE | 23.93 | 54558695 | |
| 356 | Methylation | RTVYGAVRAVPPTAI CEEEEEEECCCCCCC | 29.36 | 24129315 | |
| 356 | Asymmetric dimethylarginine | RTVYGAVRAVPPTAI CEEEEEEECCCCCCC | 29.36 | - | |
| 388 | Methylation | YGGYAAYRYAQPATA CCCEEEHCCCCCHHH | 18.65 | 24129315 | |
| 388 | Asymmetric dimethylarginine | YGGYAAYRYAQPATA CCCEEEHCCCCCHHH | 18.65 | - | |
| 440 | Methylation | GAVASLYRGGYSRFA HHHHHHHCCCCCCCC | 37.04 | 24129315 | |
| 440 | Asymmetric dimethylarginine | GAVASLYRGGYSRFA HHHHHHHCCCCCCCC | 37.04 | - | |
| 445 | Methylation | LYRGGYSRFAPY--- HHCCCCCCCCCC--- | 24.22 | 24129315 | |
| 445 | Asymmetric dimethylarginine | LYRGGYSRFAPY--- HHCCCCCCCCCC--- | 24.22 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 65 | T | Phosphorylation | Kinase | MAPK1 | P63085 | GPS |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RFOX2_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RFOX2_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| RFOX2_MOUSE | Rbfox2 | physical | 20211142 | |
| MED16_MOUSE | Med16 | physical | 20211142 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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