| UniProt ID | VPS72_MOUSE | |
|---|---|---|
| UniProt AC | Q62481 | |
| Protein Name | Vacuolar protein sorting-associated protein 72 homolog | |
| Gene Name | Vps72 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 368 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Deposition-and-exchange histone chaperone specific for H2AFZ, specifically chaperones H2AFZ and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AFZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling.. | |
| Protein Sequence | MSLAGGRAPRKTAGNRLSGLLEAEEEDEFYQTTYGGFTEESGDDEYQGDQSDTEDEVDSDFDIDEGDEPSSDGEAEEPRRKRRVVTKAYKEPLKSLRPRKVSTPASSSQKAREEKTLLPLELQDDGSDSRKSMRQSTAEHTRQTFLRVQERQGQSRRRKGPHCERPLTQEELLREAKITEELNLRSLETYERLEADKKKQVHKKRKCPGPIITYHSVTVPLVGEPGPKEENVDVEGLDPAPTASALAPHAGTGTGAAAATPPAHCSRTFITFSDDATFEEWFPQGRPPKVPVREVCPVTHRPALYRDPVTDIPYATARAFKIIREAYKKYITAHGLPPTASALGPGPPPPEPLPGSGPRALRQKIVIK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MSLAGGRAP ------CCCCCCCCC | 27.25 | 29514104 | |
| 86 | Phosphorylation | RRKRRVVTKAYKEPL HHHHHHHHHHHHHHH | 13.70 | 24719451 | |
| 89 | Phosphorylation | RRVVTKAYKEPLKSL HHHHHHHHHHHHHHC | 19.90 | 24719451 | |
| 102 | Phosphorylation | SLRPRKVSTPASSSQ HCCCCCCCCCCCCCH | 31.54 | 27087446 | |
| 103 | Phosphorylation | LRPRKVSTPASSSQK CCCCCCCCCCCCCHH | 26.34 | 29550500 | |
| 106 | Phosphorylation | RKVSTPASSSQKARE CCCCCCCCCCHHHHH | 31.55 | 24719451 | |
| 127 | Phosphorylation | LELQDDGSDSRKSMR EEECCCCCCCHHHHH | 39.13 | 26370283 | |
| 129 | Phosphorylation | LQDDGSDSRKSMRQS ECCCCCCCHHHHHHH | 43.22 | 30635358 | |
| 168 | Phosphorylation | PHCERPLTQEELLRE CCCCCCCCHHHHHHH | 36.30 | 23140645 | |
| 189 | Phosphorylation | LNLRSLETYERLEAD HCCHHHHHHHHHHHH | 35.66 | 22871156 | |
| 190 | Phosphorylation | NLRSLETYERLEADK CCHHHHHHHHHHHHH | 6.95 | 22871156 | |
| 242 | Phosphorylation | EGLDPAPTASALAPH CCCCCCCCHHHHCCC | 35.04 | 26643407 | |
| 244 | Phosphorylation | LDPAPTASALAPHAG CCCCCCHHHHCCCCC | 26.71 | 26643407 | |
| 252 | Phosphorylation | ALAPHAGTGTGAAAA HHCCCCCCCCCHHCC | 32.14 | 29550500 | |
| 254 | Phosphorylation | APHAGTGTGAAAATP CCCCCCCCCHHCCCC | 24.40 | 29550500 | |
| 260 | Phosphorylation | GTGAAAATPPAHCSR CCCHHCCCCCCCCCC | 25.69 | 29550500 | |
| 266 | Phosphorylation | ATPPAHCSRTFITFS CCCCCCCCCEEEECC | 25.21 | 29550500 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of VPS72_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of VPS72_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of VPS72_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of VPS72_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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