ZSC10_MOUSE - dbPTM
ZSC10_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ZSC10_MOUSE
UniProt AC Q3URR7
Protein Name Zinc finger and SCAN domain-containing protein 10
Gene Name Zscan10
Organism Mus musculus (Mouse).
Sequence Length 782
Subcellular Localization Nucleus .
Protein Description Embryonic stem (ES) cell-specific transcription factor required to maintain ES cell pluripotency. Can both activate and /or repress expression of target genes, depending on the context. Specifically binds the 5'-[GA]CGCNNGCG[CT]-3' DNA consensus sequence. Regulates expression of POU5F1/OCT4, ZSCAN4 and ALYREF/THOC4..
Protein Sequence MLAEPVPDALEQEHPGAVKLEEDEVGEEDPRLAESRPRPEVAHQLFRCFQYQEDMGPRASLGRLRELCNHWLRPALHTKKQILELLVLEQFLSVLPPHVLSRLHGQPLRDGEEVVQLLEGVPRDISHMGPLDFSFSAGKNAPADIISEEQNSPSQVPSHSPQTELPSEEIPALHPLNELPPPQPAPIRPAEPEEWRLAPSSNWPMSPEPQEILQDPRESNPSQGPSWLEENSRDQELAAVLESLTFEDTSEKRAWPANPLGFGSRMPDNEELKVEEPKVTTWPVVIGAESQTEKPEVAGEPLTQTVGQETSSTGWGGTPADGSEVVKVRGASDAPEPQGEMQFICTYCGVNFPEMSHLQAHQLQSHPNLQPHPSSRSFRCLWCGKTFGRSSILKLHMRTHTDERPHACHLCNRRFRQSSHLTKHLLTHSSEPAFRCAECNQGFQRRSSLMQHLLAHAQGKNLTPNPEGKTKVPEMAAVLCSHCGQTFKRRSSLKRHLRNHAKDKDHLSSEDPGSLSSSQESNPYVCSDCGKAFRQSEQLMIHTRRVHTRERPFSCQVCGRCFTQNSQLISHQQIHTGEKPHACPQCSKRFVRRAGLARHLLTHGSLRPYHCAQCGKSFRQMRDLTRHVRCHTGEKPCRCNECGEGFTQNAHLARHQRIHTGEKPHACDICGHRFRNSSNLARHRRSHTGERPYSCPTCGRSFRRNAHLQRHLITHTGSKQEKEVPQECPECGKSFNRSCNLLRHLLVHTGARPYSCALCGRSFSRNSHLLRHLRTHARESLY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
35PhosphorylationEDPRLAESRPRPEVA
CCHHHHHHCCCHHHH		41.8123737553
134PhosphorylationHMGPLDFSFSAGKNA
HCCCCCEECCCCCCC		20.2522006019
135 (in isoform 3)Phosphorylation-6.1527357545
139 (in isoform 3)Phosphorylation-50.0527357545
140 (in isoform 3)Phosphorylation-50.6827357545
147PhosphorylationNAPADIISEEQNSPS
CCCHHHCCCCCCCCC		35.1022006019
152PhosphorylationIISEEQNSPSQVPSH
HCCCCCCCCCCCCCC		26.1422006019
158PhosphorylationNSPSQVPSHSPQTEL
CCCCCCCCCCCCCCC		37.4322006019
160PhosphorylationPSQVPSHSPQTELPS
CCCCCCCCCCCCCCC		24.04-
200PhosphorylationEEWRLAPSSNWPMSP
HHCCCCCCCCCCCCC		30.6022006019
206PhosphorylationPSSNWPMSPEPQEIL
CCCCCCCCCCHHHHH		23.2522006019
226PhosphorylationSNPSQGPSWLEENSR
CCCCCCCCHHHHCCH		51.6321149613
232PhosphorylationPSWLEENSRDQELAA
CCHHHHCCHHHHHHH		40.2821149613
252UbiquitinationTFEDTSEKRAWPANP
CCCCCCCCCCCCCCC		47.38-
447PhosphorylationNQGFQRRSSLMQHLL
CHHHHHHHHHHHHHH		29.9722006019
485MethylationVLCSHCGQTFKRRSS
HHHHHCCCHHHHHHH		49.51-
508PhosphorylationAKDKDHLSSEDPGSL
HCCCCCCCCCCCCCC		28.4121149613
509PhosphorylationKDKDHLSSEDPGSLS
CCCCCCCCCCCCCCC		52.9921149613
514PhosphorylationLSSEDPGSLSSSQES
CCCCCCCCCCCCCCC		30.3921149613
516PhosphorylationSEDPGSLSSSQESNP
CCCCCCCCCCCCCCC		29.6421149613
517PhosphorylationEDPGSLSSSQESNPY
CCCCCCCCCCCCCCE		41.1421149613
518PhosphorylationDPGSLSSSQESNPYV
CCCCCCCCCCCCCEE		34.2921149613
521PhosphorylationSLSSSQESNPYVCSD
CCCCCCCCCCEECCC		35.1521149613
524PhosphorylationSSQESNPYVCSDCGK
CCCCCCCEECCCHHH		20.5221149613
527PhosphorylationESNPYVCSDCGKAFR
CCCCEECCCHHHHHH		26.3721149613
660PhosphorylationARHQRIHTGEKPHAC
HHHCCCCCCCCCCCC		44.67-
755PhosphorylationHTGARPYSCALCGRS
HCCCCCCCCCCCCCC		8.8025521595
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ZSC10_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference
485QMethylation

-
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ZSC10_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of ZSC10_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ZSC10_MOUSE

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Related Literatures of Post-Translational Modification

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