JHD2C_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: JHD2C_MOUSE
• UniProt AC: Q69ZK6
• Protein Name: Probable JmjC domain-containing histone demethylation protein 2C
• Gene Name: Jmjd1c
• Organism: Mus musculus (Mouse).
• Sequence Length: 2350
• Subcellular Localization: Nucleus.
• Protein Description: Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity)..
• Protein Sequence: MQGPYSLNGYRVRVYRQDSATQWFTGIITHHDLFTRTMIVMNDQVLEPQNVDPSMVQMTFLDDVVHSLLKGENIGITSRRRSRASQNISTVHGHYTRAQANSPRPAMNSQAAVPKQNTHQQQQQRSIRPNKRKGSDSSIPDEEKMKEDKYDCVSRGENPKGKNKHVVTKRRKPEEAEKRLSMKRLRTDNASDASESSDAESSSKRVTETSSSEPMPEYEPKNKVTSKVNGEEGQSQAAEEAGEETLIDTRPPWDQMQEDKNHNEGEKPKSTDSHLQDKMTLRSSEQATVADHNSNDSVLQECNVENQRTVELLPKDRLVSRTPTPKCVTDIKNDTHSERAAQENLNTFGLQTPENMDPNVSDSKHSNAKYLETAKQDCDQSWVSDVVKVDLTQSSVTNAPSGSDKRDTEKERNHYVSYMSSLSAVSVTEDQLHKRSPPPETIKAKLTTSVDTQKAKSSSSPEVVKPKITHSPDSVKSKAAYGNSQAVGERRLANKIEHELSRGSFHPVPTRGSALETTKSPLIIDKNEHFTVYRDPALIGSETGANHISPFLSQHPFSLHSSSHRTCLNPGTHHPALTPGPHLLAGSTSQTPLPTINTHPLTSGPHHPVHHPHLLPTVLPGVPTASLLGGHPRLESAHASSLSHLALAHQQQQQLLQHQSPHLLGQAHPSASYNQLGLYPIIWQYPNGTHAYSGLGLPSSKWVHPENAVNAEASLRRNSPSPWLHQPTPVTSADGIGLLSHIPVRPSSAEPHRPHKITVHSSPPLTKTLADHHKEELERKAFMEPLRSNASTSVKGDLDLNRSQAGKDCHLHRHFVGPRPPQETGERLNKYKEEHRRILQESIDVAPFTTKIKGHEVERENYSRVVPSSSSPKSHAIKQDKDVDRSVSEIYKMKHSVPQSLPQSNYFTTLSNSVVNEPPRSYPSKEVSNIYTEKQNNNLSATANPQTHSFISSLSKPPPLIKHQPESESLVGKIPDHLPHQSASHSVTTFRSDCRSPTHLTVSSTNALRSMPALHRAPVFHPPIHHSLERKESSYSSLSPPTLTPVMPVNAGGKVQESQKPPTLIPEPKDSQSNFKNSSDQSLTEMWRSNNNLNREKAEWPVEKSSGKSQAAVASVIVRPPSSTKVDSVPSVPLASKDRVCERSSSGANKTDYLKPEAGETGRIILPNVNLESAHVKSEKNFEAVSQGNVPVSVMSAVNVVSTTKADVFTSAATTTSVSSLSSAETSYSLSNTISASTPFECTSSKSVVSQAVAQAKDCTVSTAVPGTLACSKTGSAVQPGSGFSGTTDFIHLKKHKAALAAAQFKNSSVSEAELNTVRNQTVAASLPLDSTMTCTASNKAISVGNGPAAQSSQPNYHTKLKKAWLTRHSEEDKNTNKMENSGNSVSEIIKPCSVNLIASTSNDIENRADGRVAVDKYGRDEKVSRRKAKRTYESGSESGDSDESESKSEQRTKRQPKPTYKKKQNDLQKRKGEVEEDSKPNGVLSRSAKDKSKLKLQNSNSAGVPRSVLKDWRKVKKLKQTGESFLQDDSCCEIGPNLQKCRECRLIRSKKGEESTHSPVFCRFYYFRRLSFSKNGVVRIDGFSSPDQYDDEAMSLWTHENYEDDEVDVETSKYILDIIGDKFCQLVTSEKTALSWVKKDAKIAWKRAVRGVREMCDACEATLFNVHWVCRKCGFVACLDCYKAKERKSSRDKELYAWMKCVKGQPHDHKHLMLTQIIPGSVLTDLLDAMHILREKYGIKSHCHCTNRQNLQGGNVPTMNGVSQVLQNVLHHSNKTSVSLPESQQQNSPQKSQTNGNSSPGSASTDSRLTPPESQSPLHWLADLAEQKSREEKQENKEFTLEREIKEDGDQDASDSPNGSTSPPASQSNEQGSTLRDLLTTTAGKLRVGSTDAGIAFAPVYSMGTSSGKGGRTMPNILDDIIASVVENKIPPNKTSKINIKSEPNEEPKESSLPATDESNKSYRDIPHSWICDQHILWLKDYKNSNNWKLFKECWKQGQPAVVSGVHKKMNISLWKAESISLDFGDHQADLLNCKDSIVSNANVKEFWDGFEEVSKRQKNKGGETVVLKLKDCPSGEDFKAMMPTRYEDFLRCLPLPEYCNPEGKFNLASHLPGFFVRPDLGPRLCSAYGVAAAKDHDIGTTNLHIEASDVVNVLVYVGIAKGNGVLSKAGILKKFEEEELDDVLRKRLKDSSEIPGALWHIYAGKDVDKIREFLQKISKEQGLEVLPEHDPIRDQSWYVNRKLRQRLLEEYGVRACTLIQFLGDAIVLPAGTLHQVQNFHSCVQVTEDFVSPEHLVQSFHLTQELRLLKEEINYDDKLQVKNILYHAVKEMVRALKMHEDEVEDMEDT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
25	Phosphorylation	DSATQWFTGIITHHD CCCHHHHCEEEHHHH	25.22	28059163
29	Phosphorylation	QWFTGIITHHDLFTR HHHCEEEHHHHHCCC	15.96	28059163
102	Phosphorylation	YTRAQANSPRPAMNS HHHHHCCCCCCCCCC	25.87	25338131
118	Phosphorylation	AAVPKQNTHQQQQQR CCCCCCCHHHHHHHH	20.68	-
126	Phosphorylation	HQQQQQRSIRPNKRK HHHHHHHCCCCCCCC	20.72	-
135	Phosphorylation	RPNKRKGSDSSIPDE CCCCCCCCCCCCCCH	37.04	27087446
137	Phosphorylation	NKRKGSDSSIPDEEK CCCCCCCCCCCCHHH	31.68	27087446
138	Phosphorylation	KRKGSDSSIPDEEKM CCCCCCCCCCCHHHH	43.03	27087446
168	Phosphorylation	GKNKHVVTKRRKPEE CCCCCCCCCCCCHHH	20.11	22802335
178	Acetylation	RKPEEAEKRLSMKRL CCHHHHHHHHHHHHH	66.73	22902405
178	Succinylation	RKPEEAEKRLSMKRL CCHHHHHHHHHHHHH	66.73	23954790
181	Phosphorylation	EEAEKRLSMKRLRTD HHHHHHHHHHHHHCC	26.70	22942356
187	Phosphorylation	LSMKRLRTDNASDAS HHHHHHHCCCCCCCC	37.89	21183079
191	Phosphorylation	RLRTDNASDASESSD HHHCCCCCCCCCCCC	39.71	25159016
194	Phosphorylation	TDNASDASESSDAES CCCCCCCCCCCCCHH	42.90	25159016
196	Phosphorylation	NASDASESSDAESSS CCCCCCCCCCCHHHC	30.90	25159016
197	Phosphorylation	ASDASESSDAESSSK CCCCCCCCCCHHHCC	36.47	25159016
201	Phosphorylation	SESSDAESSSKRVTE CCCCCCHHHCCCCCC	41.45	29550500
202	Phosphorylation	ESSDAESSSKRVTET CCCCCHHHCCCCCCC	31.24	29550500
203	Phosphorylation	SSDAESSSKRVTETS CCCCHHHCCCCCCCC	33.49	29550500
207	Phosphorylation	ESSSKRVTETSSSEP HHHCCCCCCCCCCCC	37.26	30635358
209	Phosphorylation	SSKRVTETSSSEPMP HCCCCCCCCCCCCCC	25.25	30635358
210	Phosphorylation	SKRVTETSSSEPMPE CCCCCCCCCCCCCCC	26.15	30635358
211	Phosphorylation	KRVTETSSSEPMPEY CCCCCCCCCCCCCCC	46.25	30635358
212	Phosphorylation	RVTETSSSEPMPEYE CCCCCCCCCCCCCCC	45.55	30635358
284	Phosphorylation	DKMTLRSSEQATVAD HHHHHCCCCCCCCCC	27.56	22802335
288	Phosphorylation	LRSSEQATVADHNSN HCCCCCCCCCCCCCC	18.87	21082442
294	Phosphorylation	ATVADHNSNDSVLQE CCCCCCCCCCHHHHH	38.30	21183079
297	Phosphorylation	ADHNSNDSVLQECNV CCCCCCCHHHHHCCC	29.04	30635358
320	Phosphorylation	LPKDRLVSRTPTPKC CCCCCCCCCCCCCCC	34.72	26824392
322	Phosphorylation	KDRLVSRTPTPKCVT CCCCCCCCCCCCCCC	24.81	26824392
324	Phosphorylation	RLVSRTPTPKCVTDI CCCCCCCCCCCCCCC	34.46	26824392
392	Phosphorylation	DVVKVDLTQSSVTNA CCEEEECCCCCCCCC	23.18	25293948
394	Phosphorylation	VKVDLTQSSVTNAPS EEEECCCCCCCCCCC	22.88	25293948
395	Phosphorylation	KVDLTQSSVTNAPSG EEECCCCCCCCCCCC	24.12	25293948
397	Phosphorylation	DLTQSSVTNAPSGSD ECCCCCCCCCCCCCC	27.84	25293948
401	Phosphorylation	SSVTNAPSGSDKRDT CCCCCCCCCCCCCCC	48.82	25293948
403	Phosphorylation	VTNAPSGSDKRDTEK CCCCCCCCCCCCCHH	44.27	25293948
420	Phosphorylation	NHYVSYMSSLSAVSV HHHHHHHHHHCEEEC	21.64	-
436	Phosphorylation	EDQLHKRSPPPETIK HHHHHCCCCCCHHHH	46.70	22942356
449	Phosphorylation	IKAKLTTSVDTQKAK HHHEEEECCCCCCCC	16.86	28576409
452	Phosphorylation	KLTTSVDTQKAKSSS EEEECCCCCCCCCCC	29.79	28059163
457	Phosphorylation	VDTQKAKSSSSPEVV CCCCCCCCCCCCCHH	40.07	29895711
458	Phosphorylation	DTQKAKSSSSPEVVK CCCCCCCCCCCCHHC	33.84	27600695
459	Phosphorylation	TQKAKSSSSPEVVKP CCCCCCCCCCCHHCC	57.93	23684622
460	Phosphorylation	QKAKSSSSPEVVKPK CCCCCCCCCCHHCCC	27.33	23684622
469	Phosphorylation	EVVKPKITHSPDSVK CHHCCCCCCCCHHHH	23.56	24453211
471	Phosphorylation	VKPKITHSPDSVKSK HCCCCCCCCHHHHHH	23.04	25521595
474	Phosphorylation	KITHSPDSVKSKAAY CCCCCCHHHHHHHHH	34.52	25159016
517	Phosphorylation	TRGSALETTKSPLII CCCCCCCCCCCCEEE	40.13	26643407
518	Phosphorylation	RGSALETTKSPLIID CCCCCCCCCCCEEEC	21.83	28066266
520	Phosphorylation	SALETTKSPLIIDKN CCCCCCCCCEEECCC	23.89	26643407
731	O-linked_Glycosylation	LHQPTPVTSADGIGL CCCCCCCCCCCCCCC	21.28	51588519
758	Phosphorylation	PHRPHKITVHSSPPL CCCCCCEEECCCCCC	19.57	28833060
761	Phosphorylation	PHKITVHSSPPLTKT CCCEEECCCCCCHHH	39.96	26824392
762	Phosphorylation	HKITVHSSPPLTKTL CCEEECCCCCCHHHH	18.69	26824392
766	Phosphorylation	VHSSPPLTKTLADHH ECCCCCCHHHHHHHC	27.97	28833060
788	Phosphorylation	AFMEPLRSNASTSVK HHHHHHHHCCCCCCC	44.42	22802335
791	Phosphorylation	EPLRSNASTSVKGDL HHHHHCCCCCCCCCC	26.01	22802335
792	Phosphorylation	PLRSNASTSVKGDLD HHHHCCCCCCCCCCC	34.82	22802335
793	Phosphorylation	LRSNASTSVKGDLDL HHHCCCCCCCCCCCC	21.24	22802335
803	Phosphorylation	GDLDLNRSQAGKDCH CCCCCCHHHCCCCCE	24.25	22802335
842	Phosphorylation	HRRILQESIDVAPFT HHHHHHHHCCCCCCC	15.89	21183079
849	Phosphorylation	SIDVAPFTTKIKGHE HCCCCCCCCCCCCEE	26.56	21183079
862	Phosphorylation	HEVERENYSRVVPSS EEEECCCCCCCCCCC	7.97	30635358
863	Phosphorylation	EVERENYSRVVPSSS EEECCCCCCCCCCCC	30.13	30635358
868	Phosphorylation	NYSRVVPSSSSPKSH CCCCCCCCCCCCCCC	31.10	26745281
869	Phosphorylation	YSRVVPSSSSPKSHA CCCCCCCCCCCCCCC	28.85	26745281
870	Phosphorylation	SRVVPSSSSPKSHAI CCCCCCCCCCCCCCC	55.80	24453211
871	Phosphorylation	RVVPSSSSPKSHAIK CCCCCCCCCCCCCCC	37.99	24453211
874	Phosphorylation	PSSSSPKSHAIKQDK CCCCCCCCCCCCCCC	22.87	30635358
911	O-linked_Glycosylation	SNYFTTLSNSVVNEP CCCCCCCCCCCCCCC	25.60	51588511
992	Phosphorylation	HSVTTFRSDCRSPTH CCCEEECCCCCCCCE	36.55	25159016
996	Phosphorylation	TFRSDCRSPTHLTVS EECCCCCCCCEEEEC	40.25	26824392
998	Phosphorylation	RSDCRSPTHLTVSST CCCCCCCCEEEECCC	38.52	28638064
1001	Phosphorylation	CRSPTHLTVSSTNAL CCCCCEEEECCCCHH	15.67	25159016
1003	Phosphorylation	SPTHLTVSSTNALRS CCCEEEECCCCHHHC	26.64	25159016
1004	Phosphorylation	PTHLTVSSTNALRSM CCEEEECCCCHHHCC	22.73	25159016
1005	Phosphorylation	THLTVSSTNALRSMP CEEEECCCCHHHCCC	19.60	25159016
1033	Phosphorylation	HSLERKESSYSSLSP CCCCCCCCCCCCCCC	37.30	26643407
1034	Phosphorylation	SLERKESSYSSLSPP CCCCCCCCCCCCCCC	30.08	26643407
1035	Phosphorylation	LERKESSYSSLSPPT CCCCCCCCCCCCCCC	16.14	25777480
1036	Phosphorylation	ERKESSYSSLSPPTL CCCCCCCCCCCCCCC	27.10	25777480
1037	Phosphorylation	RKESSYSSLSPPTLT CCCCCCCCCCCCCCC	25.32	26643407
1039	Phosphorylation	ESSYSSLSPPTLTPV CCCCCCCCCCCCCCC	30.68	25266776
1042	Phosphorylation	YSSLSPPTLTPVMPV CCCCCCCCCCCCCCC	46.80	25266776
1044	Phosphorylation	SLSPPTLTPVMPVNA CCCCCCCCCCCCCCC	19.13	25777480
1105	Phosphorylation	AEWPVEKSSGKSQAA CCCCCCCCCCCCCEE	30.71	-
1122	Phosphorylation	SVIVRPPSSTKVDSV EEEECCCCCCCCCCC	54.01	28285833
1137	Acetylation	PSVPLASKDRVCERS CCCCCCCCCCCCCCC	43.90	23806337
1146	Phosphorylation	RVCERSSSGANKTDY CCCCCCCCCCCCCCC	43.07	25338131
1151	Phosphorylation	SSSGANKTDYLKPEA CCCCCCCCCCCCCCC	29.68	28059163
1250	O-linked_Glycosylation	TSSKSVVSQAVAQAK CCCHHHHHHHHHHCC	15.40	51588527
1435	Phosphorylation	KAKRTYESGSESGDS HCCHHHCCCCCCCCC	36.89	-
1437	Phosphorylation	KRTYESGSESGDSDE CHHHCCCCCCCCCCC	37.56	-
1447	Phosphorylation	GDSDESESKSEQRTK CCCCCCCCHHHHHHH	51.24	-
1500	Phosphorylation	SKLKLQNSNSAGVPR HHCCCCCCCCCCCCH	21.14	25266776
1502	Phosphorylation	LKLQNSNSAGVPRSV CCCCCCCCCCCCHHH	26.65	30635358
1759	Phosphorylation	LQGGNVPTMNGVSQV CCCCCCCCCCHHHHH	20.98	22802335
1764	Phosphorylation	VPTMNGVSQVLQNVL CCCCCHHHHHHHHHH	18.90	22802335
1777	Phosphorylation	VLHHSNKTSVSLPES HHHHCCCCCCCCCHH	38.31	25619855
1780	Phosphorylation	HSNKTSVSLPESQQQ HCCCCCCCCCHHHHC	37.66	28285833
1784	Phosphorylation	TSVSLPESQQQNSPQ CCCCCCHHHHCCCCC	31.20	25619855
1789	Phosphorylation	PESQQQNSPQKSQTN CHHHHCCCCCCCCCC	25.11	25521595
1795	Phosphorylation	NSPQKSQTNGNSSPG CCCCCCCCCCCCCCC	52.78	23984901
1799	Phosphorylation	KSQTNGNSSPGSAST CCCCCCCCCCCCCCC	39.03	21183079
1800	Phosphorylation	SQTNGNSSPGSASTD CCCCCCCCCCCCCCC	36.96	22006019
1803	Phosphorylation	NGNSSPGSASTDSRL CCCCCCCCCCCCCCC	23.56	23984901
1805	Phosphorylation	NSSPGSASTDSRLTP CCCCCCCCCCCCCCC	34.15	23984901
1806	Phosphorylation	SSPGSASTDSRLTPP CCCCCCCCCCCCCCC	37.40	23984901
1808	Phosphorylation	PGSASTDSRLTPPES CCCCCCCCCCCCCHH	29.31	21183079
1811	Phosphorylation	ASTDSRLTPPESQSP CCCCCCCCCCHHCCH	35.37	26643407
1815	Phosphorylation	SRLTPPESQSPLHWL CCCCCCHHCCHHHHH	41.55	26745281
1817	Phosphorylation	LTPPESQSPLHWLAD CCCCHHCCHHHHHHH	38.41	29895711
1855	Phosphorylation	EDGDQDASDSPNGST HCCCCCCCCCCCCCC	47.08	25619855
1857	Phosphorylation	GDQDASDSPNGSTSP CCCCCCCCCCCCCCC	20.12	25619855
1861	Phosphorylation	ASDSPNGSTSPPASQ CCCCCCCCCCCCCHH	32.14	25619855
1862	Phosphorylation	SDSPNGSTSPPASQS CCCCCCCCCCCCHHC	46.80	25619855
1863	Phosphorylation	DSPNGSTSPPASQSN CCCCCCCCCCCHHCC	30.50	25619855
1867	Phosphorylation	GSTSPPASQSNEQGS CCCCCCCHHCCCCCC	39.66	25619855
1869	Phosphorylation	TSPPASQSNEQGSTL CCCCCHHCCCCCCHH	39.58	25619855
1874	Phosphorylation	SQSNEQGSTLRDLLT HHCCCCCCHHHHHHH	24.78	25619855
1875	Phosphorylation	QSNEQGSTLRDLLTT HCCCCCCHHHHHHHH	32.41	25619855
1891	Phosphorylation	AGKLRVGSTDAGIAF CCCEECCCCCCCEEE	21.91	28833060
1892	Phosphorylation	GKLRVGSTDAGIAFA CCEECCCCCCCEEEE	24.76	28833060

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of JHD2C_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of JHD2C_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of JHD2C_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of JHD2C_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-135, AND MASSSPECTROMETRY.
PubMed: 19367708