UniProt ID | NUFP2_MOUSE | |
---|---|---|
UniProt AC | Q5F2E7 | |
Protein Name | Nuclear fragile X mental retardation-interacting protein 2 | |
Gene Name | Nufip2 | |
Organism | Mus musculus (Mouse). | |
Sequence Length | 692 | |
Subcellular Localization | Nucleus . Cytoplasm . Cytoplasm, Stress granule . Localized in both nucleus and cytoplasm in most neurons. In the cortex, distributed in a diffuse way in the nucleus and in the cytoplasm. Localized in the cytoplasm in neurons of the dentate gyrus in | |
Protein Description | Binds RNA.. | |
Protein Sequence | MEEKPGQPQPQHHHSHHHPHHHPQQQQQQQSHHHHHYYFYNHSHNHHHHHHHQQPHQYLQHGAEGSPKAQPKPLKHEQKHTLQQHQETPKKKTGYGEINGNAGEREISLKSLSSDEATNPISRVLNGNQQVVETSLKQTVKTSTFGKAGIKTKNFIQKNSMDKKNGKSYENKSGETQAVDKTDTIAIPNGVITSSSGYITNGYMSKGADNDGSGSESGYTTPKKRKARRNSAKGCENLNLVQDKIMQETSVPALKQGLETLKPDYSEQKGMRVDGSKPIWKYETGPGGTSRGKPAMGDVLRKSSDIKPGLSSKKFDDRPKGKHASAAASKEDSWTLFKPPPVFPVDNSSAKIVPKISYASKVKENLNKTVQNSSVSPSSSSSSSSTGETQTQSSSRLSQVPMSALKSVTSASFSNGPVLAGTDGSVYPSGGQPLLTTAANTLTPISTGTDSVLQDMSLASAAVEQIKSSLFIYPSNMQTVLLSAQVDLPSQTDQQNLGDIFQNQWGLSFINEPSAGPETVIGKSSDHKVMEVTFQGEYPATLVSQGAEIIPSGTEHPVFPKAYELEKRTSPQVLGHILKPGTTESGALSLDPSHIGDLQKADTSSQGALVFLSKDYEIENQNPLASPTNTLLGSAKEQRYQRGLERNDSWGSFDLRAAIVYHTKEMESIWNLQKQDPKRIITYNEAMDSPDQ | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
88 | Phosphorylation | TLQQHQETPKKKTGY HHHHHCCCCCCCCCC | 33.56 | 25266776 | |
95 | Phosphorylation | TPKKKTGYGEINGNA CCCCCCCCCCCCCCC | 19.47 | 72115 | |
111 | Phosphorylation | EREISLKSLSSDEAT CEEEEEEECCCCCCC | 38.48 | 27087446 | |
113 | Phosphorylation | EISLKSLSSDEATNP EEEEEECCCCCCCCH | 42.72 | 27087446 | |
114 | Phosphorylation | ISLKSLSSDEATNPI EEEEECCCCCCCCHH | 44.77 | 22942356 | |
118 | Phosphorylation | SLSSDEATNPISRVL ECCCCCCCCHHHHHH | 39.21 | 25619855 | |
135 | Phosphorylation | NQQVVETSLKQTVKT CHHEEEEEHHHHHCC | 21.77 | 26026062 | |
147 | Ubiquitination | VKTSTFGKAGIKTKN HCCCCCCCCCCCCCC | 38.97 | 27667366 | |
160 | Phosphorylation | KNFIQKNSMDKKNGK CCCHHHCCCCCCCCC | 35.08 | 29514104 | |
213 | Phosphorylation | KGADNDGSGSESGYT CCCCCCCCCCCCCCC | 41.85 | 27087446 | |
215 | Phosphorylation | ADNDGSGSESGYTTP CCCCCCCCCCCCCCH | 30.22 | 25521595 | |
217 | Phosphorylation | NDGSGSESGYTTPKK CCCCCCCCCCCCHHH | 38.50 | 6458829 | |
219 | Phosphorylation | GSGSESGYTTPKKRK CCCCCCCCCCHHHHH | 19.40 | 23684622 | |
220 | Phosphorylation | SGSESGYTTPKKRKA CCCCCCCCCHHHHHH | 39.90 | 25521595 | |
221 | Phosphorylation | GSESGYTTPKKRKAR CCCCCCCCHHHHHHH | 25.32 | 25521595 | |
231 | Phosphorylation | KRKARRNSAKGCENL HHHHHHHCCCCCCCH | 29.55 | 22942356 | |
282 | Phosphorylation | GSKPIWKYETGPGGT CCCCCEEEECCCCCC | 12.06 | 20531401 | |
284 | Phosphorylation | KPIWKYETGPGGTSR CCCEEEECCCCCCCC | 45.66 | 20531401 | |
290 | Phosphorylation | ETGPGGTSRGKPAMG ECCCCCCCCCCCCCH | 42.16 | 20531401 | |
291 | Methylation | TGPGGTSRGKPAMGD CCCCCCCCCCCCCHH | 57.92 | - | |
293 | Acetylation | PGGTSRGKPAMGDVL CCCCCCCCCCCHHHH | 28.61 | 19849209 | |
303 | Phosphorylation | MGDVLRKSSDIKPGL CHHHHHHCCCCCCCC | 27.15 | 29895711 | |
304 | Phosphorylation | GDVLRKSSDIKPGLS HHHHHHCCCCCCCCC | 46.52 | 28507225 | |
311 | Phosphorylation | SDIKPGLSSKKFDDR CCCCCCCCCCCCCCC | 46.13 | 22418434 | |
312 | Phosphorylation | DIKPGLSSKKFDDRP CCCCCCCCCCCCCCC | 44.93 | 22418434 | |
369 | Phosphorylation | VKENLNKTVQNSSVS HHHHHHHHHHCCCCC | 26.67 | 26643407 | |
373 | Phosphorylation | LNKTVQNSSVSPSSS HHHHHHCCCCCCCCC | 18.28 | 26643407 | |
374 | Phosphorylation | NKTVQNSSVSPSSSS HHHHHCCCCCCCCCC | 33.88 | 26643407 | |
376 | Phosphorylation | TVQNSSVSPSSSSSS HHHCCCCCCCCCCCC | 22.47 | 24453211 | |
378 | Phosphorylation | QNSSVSPSSSSSSSS HCCCCCCCCCCCCCC | 35.03 | 26643407 | |
379 | Phosphorylation | NSSVSPSSSSSSSST CCCCCCCCCCCCCCC | 37.31 | 23140645 | |
380 | Phosphorylation | SSVSPSSSSSSSSTG CCCCCCCCCCCCCCC | 38.28 | 23140645 | |
381 | Phosphorylation | SVSPSSSSSSSSTGE CCCCCCCCCCCCCCC | 35.87 | 23140645 | |
382 | Phosphorylation | VSPSSSSSSSSTGET CCCCCCCCCCCCCCC | 35.87 | 23140645 | |
383 | Phosphorylation | SPSSSSSSSSTGETQ CCCCCCCCCCCCCCC | 30.20 | 23140645 | |
384 | Phosphorylation | PSSSSSSSSTGETQT CCCCCCCCCCCCCCC | 33.59 | 23140645 | |
385 | Phosphorylation | SSSSSSSSTGETQTQ CCCCCCCCCCCCCCC | 42.24 | 23140645 | |
386 | Phosphorylation | SSSSSSSTGETQTQS CCCCCCCCCCCCCCC | 40.77 | 23140645 | |
403 | Phosphorylation | RLSQVPMSALKSVTS HHHHCCHHHHHHHHC | 25.12 | 29514104 | |
569 | Phosphorylation | AYELEKRTSPQVLGH HHHCCCCCCCCHHCE | 56.69 | 26824392 | |
570 | Phosphorylation | YELEKRTSPQVLGHI HHCCCCCCCCHHCEE | 19.85 | 26824392 | |
582 | Phosphorylation | GHILKPGTTESGALS CEECCCCCCCCCCCC | 35.60 | 25777480 | |
583 | Phosphorylation | HILKPGTTESGALSL EECCCCCCCCCCCCC | 33.78 | 25777480 | |
585 | Phosphorylation | LKPGTTESGALSLDP CCCCCCCCCCCCCCH | 27.55 | 25777480 | |
589 | Phosphorylation | TTESGALSLDPSHIG CCCCCCCCCCHHHHC | 30.14 | 25777480 | |
593 | Phosphorylation | GALSLDPSHIGDLQK CCCCCCHHHHCCHHH | 27.66 | 25777480 | |
603 | Phosphorylation | GDLQKADTSSQGALV CCHHHCCCCCCCEEE | 34.83 | 23984901 | |
604 | Phosphorylation | DLQKADTSSQGALVF CHHHCCCCCCCEEEE | 22.63 | 26643407 | |
605 | Phosphorylation | LQKADTSSQGALVFL HHHCCCCCCCEEEEE | 34.42 | 29514104 | |
613 | Phosphorylation | QGALVFLSKDYEIEN CCEEEEECCCCEECC | 16.41 | 30635358 | |
616 | Phosphorylation | LVFLSKDYEIENQNP EEEECCCCEECCCCC | 23.65 | 25619855 | |
626 | Phosphorylation | ENQNPLASPTNTLLG CCCCCCCCCCCHHHC | 39.68 | 24925903 | |
628 | Phosphorylation | QNPLASPTNTLLGSA CCCCCCCCCHHHCCH | 38.04 | 25521595 | |
630 | Phosphorylation | PLASPTNTLLGSAKE CCCCCCCHHHCCHHH | 26.32 | 24925903 | |
634 | Phosphorylation | PTNTLLGSAKEQRYQ CCCHHHCCHHHHHHH | 35.82 | 24925903 | |
649 | Phosphorylation | RGLERNDSWGSFDLR HHCCCCCCCCCCHHH | 36.56 | 18388127 | |
652 | Phosphorylation | ERNDSWGSFDLRAAI CCCCCCCCCHHHHHE | 14.88 | 21082442 | |
682 | Phosphorylation | QDPKRIITYNEAMDS CCCCCEEECHHHCCC | 20.23 | 25619855 | |
683 | Phosphorylation | DPKRIITYNEAMDSP CCCCEEECHHHCCCC | 10.70 | 25619855 | |
689 | Phosphorylation | TYNEAMDSPDQ---- ECHHHCCCCCC---- | 19.79 | 25521595 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NUFP2_MOUSE !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NUFP2_MOUSE !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NUFP2_MOUSE !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
Oops, there are no PPI records of NUFP2_MOUSE !! |
Kegg Drug | ||||||
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DrugBank | ||||||
There are no disease associations of PTM sites. |
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Phosphorylation | |
Reference | PubMed |
"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry."; Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.; Mol. Cell. Proteomics 8:904-912(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-649, AND MASSSPECTROMETRY. | |
"The phagosomal proteome in interferon-gamma-activated macrophages."; Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.; Immunity 30:143-154(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-649, AND MASSSPECTROMETRY. | |
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-113; SER-213 ANDSER-215, AND MASS SPECTROMETRY. | |
"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations."; Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.; Mol. Cell. Proteomics 6:283-293(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-649, AND MASSSPECTROMETRY. | |
"Phosphoproteomic analysis of the developing mouse brain."; Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.; Mol. Cell. Proteomics 3:1093-1101(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-626, AND MASSSPECTROMETRY. |