ARI1A_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ARI1A_MOUSE
• UniProt AC: A2BH40
• Protein Name: AT-rich interactive domain-containing protein 1A
• Gene Name: Arid1a
• Organism: Mus musculus (Mouse).
• Sequence Length: 2283
• Subcellular Localization: Nucleus .
• Protein Description: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. [PubMed: 22952240]
• Protein Sequence: MAAQVAPAAASSLGNPPPPPSELKKAEQQQREEAGGEAAAAAAERGEMKAAAGQESEGPAVGPPQPLGKELQDGAESNGGGGGGGAGSGGGPGAEPDLKNSNGNAGPRPALNNNLPEPPGGGGGGGSSSSDGVGAPPHSAAAALPPPAYGFGQAYGRSPSAVAAAAAAVFHQQHGGQQSPGLAALQSGGGGGLEPYAGPQQNSHDHGFPNHQYNSYYPNRSAYPPPPQAYALSSPRGGTPGSGAAAAAGSKPPPSSSASASSSSSSFAQQRFGAMGGGGPSAAGGGTPQPTATPTLNQLLTSPSSARGYQGYPGGDYGGGPQDGGAGKGPADMASQCWGAAAAAAAAAAAVSGGAQQRSHHAPMSPGSSGGGGQPLARTPQSSSPMDQMGKMRPQPYGGTNPYSQQQGPPSGPQQGHGYPGQPYGSQTPQRYPMTMQGRAQSAMGSLSYAQQIPPYGQQGPSAYGQQGQTPYYNQQSPHPQQQPPYAQQPPSQTPHAQPSYQQQPQTQQPQLQSSQPPYSQQPSQPPHQQSPTPYPSQQSTTQQHPQSQPPYSQPQAQSPYQQQQPQQPASSSLSQQAAYPQPQPQQSQQTAYSQQRFPPPQELSQDSFGSQASSAPSMTSSKGGQEDMNLSLQSRPSSLPDLSGSIDDLPMGTEGALSPGVSTSGISSSQGEQSNPAQSPFSPHTSPHLPGIRGPSPSPVGSPASVAQSRSGPLSPAAVPGNQMPPRPPSGQSDSIMHPSMNQSSIAQDRGYMQRNPQMPQYTSPQPGSALSPRQPSGGQMHSGVGSYQQNSMGSYGPQGSQYGPQGGYPRQPNYNALPNANYPNAGMAGSMNPMGAGGQMHGQPGIPPYGTLPPGRMAHASMGNRPYGPNMANMPPQVGSGMCPPPGGMNRKTQESAVAMHVAANSIQNRPPGYPNMNQGGMMGTGPPYGQGINSMAGMINPQGPPYPMGGTMANNSAGMAASPEMMGLGDVKLTPATKMNNKADGTPKTESKSKKSSSSTTTNEKITKLYELGGEPERKMWVDRYLAFTEEKAMGMTNLPAVGRKPLDLYRLYVSVKEIGGLTQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQCLYAFECKIERGEDPPPDIFAAADSKKSQPKIQPPSPAGSGSMQGPQTPQSTSSSMAEGGDLKPPTPASTPHSQIPPLPGMSRSNSVGIQDAFPDGSDPTFQKRNSMTPNPGYQPSMNTSDMMGRMSYEPNKDPYGSMRKAPGSDPFMSSGQGPNGGMGDPYSRAAGPGLGSVAMGPRQHYPYGGPYDRVRTEPGIGPEGNMGTGAPQPNLMPSTPDSGMYSPSRYPPQQQQQQQQQHDSYGNQFSTQGTPSSSPFPSQQTTMYQQQQQNYKRPMDGTYGPPAKRHEGEMYSVPYSAGQGQPQQQQLPAAQSQPASQPQAAQPSPQQDVYNQYSNAYPASATAATDRRPAGGPQNQFPFQFGRDRVSAPPGSSAQQNMPPQMMGGPIQASAEVAQQGTMWQGRNDMTYNYANRQNTGSATQGPAYHGVNRTDEMLHTDQRANHEGPWPSHGTRQPPYGPSAPVPPMTRPPPSNYQPPPSMPNHIPQVSSPAPLPRPMENRTSPSKSPFLHSGMKMQKAGPPVPASHIAPTPVQPPMIRRDITFPPGSVEATQPVLKQRRRLTMKDIGTPEAWRVMMSLKSGLLAESTWALDTINILLYDDNSIMTFNLSQLPGLLELLVEYFRRCLIEIFGILKEYEVGDPGQRTLLDPGRFTKVYSPAHTEEEEEEHLDPKLEEEEEEGVGNDEEMAFLGKDKPSSENNEEKLVSKFDKLPVKIVQRNDPFVVDCSDKLGRVQEFDSGLLHWRIGGGDTTEHIQTHFESKIELLPSRPYVPCPTPPRKHLTTVEGTPGTTEQEGPPPDGLPEKRITATMDDMLSTRSSTLTDEGAKSAEATKESSKFPFGISPAQSHRNIKILEDEPHSKDETPLCTLLDWQDSLAKRCVCVSNTIRSLSFVPGNDFEMSKHPGLLLILGKLILLHHKHPERKQAPLTYEKEEEQDQGVSCDKVEWWWDCLEMLRENTLVTLANISGQLDLSPYPESICLPVLDGLLHWAVCPSAEAQDPFSTLGPNAVLSPQRLVLETLSKLSIQDNNVDLILATPPFSRLEKLYSTMVRFLSDRKNPVCREMAVVLLANLAQGDSLAARAIAVQKGSIGNLLGFLEDSLAATQFQQSQASLLHMQNPPFEPTSVDMMRRAARALLALAKVDENHSEFTLYESRLLDISVSPLMNSLVSQVICDVLFLIGQS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAQVAPAA ------CCCCCCHHH	20.22	-
24	Acetylation	PPPPSELKKAEQQQR CCCHHHHHHHHHHHH	45.98	22902405
56	Phosphorylation	KAAAGQESEGPAVGP HHHCCCCCCCCCCCC	39.71	-
69	Acetylation	GPPQPLGKELQDGAE CCCCCCCHHHCCCCC	64.03	22902405
77	Phosphorylation	ELQDGAESNGGGGGG HHCCCCCCCCCCCCC	39.99	30635358
88	Phosphorylation	GGGGGAGSGGGPGAE CCCCCCCCCCCCCCC	33.46	30635358
221	Phosphorylation	NSYYPNRSAYPPPPQ CCCCCCCCCCCCCCC	38.50	23527152
230	Phosphorylation	YPPPPQAYALSSPRG CCCCCCCEEECCCCC	11.65	26643407
233	Phosphorylation	PPQAYALSSPRGGTP CCCCEEECCCCCCCC	30.08	23527152
234	Phosphorylation	PQAYALSSPRGGTPG CCCEEECCCCCCCCC	21.33	25266776
281	Phosphorylation	AMGGGGPSAAGGGTP CCCCCCCCCCCCCCC	33.74	25777480
287	Phosphorylation	PSAAGGGTPQPTATP CCCCCCCCCCCCCCC	23.25	25777480
291	Phosphorylation	GGGTPQPTATPTLNQ CCCCCCCCCCCCHHH	37.61	25777480
293	Phosphorylation	GTPQPTATPTLNQLL CCCCCCCCCCHHHHH	21.20	25777480
295	Phosphorylation	PQPTATPTLNQLLTS CCCCCCCCHHHHHCC	33.70	25777480
301	Phosphorylation	PTLNQLLTSPSSARG CCHHHHHCCCCCCCC	47.38	25777480
302	Phosphorylation	TLNQLLTSPSSARGY CHHHHHCCCCCCCCC	23.82	24453211
304	Phosphorylation	NQLLTSPSSARGYQG HHHHCCCCCCCCCCC	36.08	25777480
305	Phosphorylation	QLLTSPSSARGYQGY HHHCCCCCCCCCCCC	25.93	26643407
312	Phosphorylation	SARGYQGYPGGDYGG CCCCCCCCCCCCCCC	5.33	24704852
359	Phosphorylation	SGGAQQRSHHAPMSP HCCCCCCCCCCCCCC	18.45	27087446
365	Phosphorylation	RSHHAPMSPGSSGGG CCCCCCCCCCCCCCC	25.67	27087446
368	Phosphorylation	HAPMSPGSSGGGGQP CCCCCCCCCCCCCCC	29.24	27742792
369	Phosphorylation	APMSPGSSGGGGQPL CCCCCCCCCCCCCCC	47.58	25619855
379	Phosphorylation	GGQPLARTPQSSSPM CCCCCCCCCCCCCCH	21.77	28833060
382	Phosphorylation	PLARTPQSSSPMDQM CCCCCCCCCCCHHHC	33.71	25521595
383	Phosphorylation	LARTPQSSSPMDQMG CCCCCCCCCCHHHCC	32.96	28833060
384	Phosphorylation	ARTPQSSSPMDQMGK CCCCCCCCCHHHCCC	29.50	25521595
431	Asymmetric dimethylarginine	YGSQTPQRYPMTMQG CCCCCCCCCCCCCCC	38.43	-
431	Methylation	YGSQTPQRYPMTMQG CCCCCCCCCCCCCCC	38.43	24129315
605	Phosphorylation	FPPPQELSQDSFGSQ CCCCHHHCCCCCCCC	31.05	27180971
608	Phosphorylation	PQELSQDSFGSQASS CHHHCCCCCCCCCCC	24.70	28833060
618	Phosphorylation	SQASSAPSMTSSKGG CCCCCCCCCCCCCCC	34.12	28285833
632	Phosphorylation	GQEDMNLSLQSRPSS CCCCCCEEHHCCCCC	21.25	28066266
635	Phosphorylation	DMNLSLQSRPSSLPD CCCEEHHCCCCCCCC	51.99	28066266
697	Phosphorylation	LPGIRGPSPSPVGSP CCCCCCCCCCCCCCH	40.61	24925903
699	Phosphorylation	GIRGPSPSPVGSPAS CCCCCCCCCCCCHHH	36.23	25521595
703	Phosphorylation	PSPSPVGSPASVAQS CCCCCCCCHHHHHCC	19.95	24925903
706	Phosphorylation	SPVGSPASVAQSRSG CCCCCHHHHHCCCCC	22.75	24925903
710	Phosphorylation	SPASVAQSRSGPLSP CHHHHHCCCCCCCCC	20.76	25619855
712	Phosphorylation	ASVAQSRSGPLSPAA HHHHCCCCCCCCCCC	50.43	27087446
716	Phosphorylation	QSRSGPLSPAAVPGN CCCCCCCCCCCCCCC	18.67	27087446
731	Phosphorylation	QMPPRPPSGQSDSIM CCCCCCCCCCCCCCC	52.74	27087446
734	Phosphorylation	PRPPSGQSDSIMHPS CCCCCCCCCCCCCCC	36.53	26643407
736	Phosphorylation	PPSGQSDSIMHPSMN CCCCCCCCCCCCCCC	27.36	26643407
741	Phosphorylation	SDSIMHPSMNQSSIA CCCCCCCCCCHHHHH	18.71	26643407
745	Phosphorylation	MHPSMNQSSIAQDRG CCCCCCHHHHHHHCC	20.78	26643407
746	Phosphorylation	HPSMNQSSIAQDRGY CCCCCHHHHHHHCCH	16.51	26643407
750 (in isoform 4)	Phosphorylation	-	36.63	24453211
756 (in isoform 4)	Phosphorylation	-	40.02	25338131
762 (in isoform 4)	Phosphorylation	-	49.12	25338131
763	Phosphorylation	RNPQMPQYTSPQPGS CCCCCCCCCCCCCCC	11.87	25619855
764	Phosphorylation	NPQMPQYTSPQPGSA CCCCCCCCCCCCCCC	28.78	21082442
765	Phosphorylation	PQMPQYTSPQPGSAL CCCCCCCCCCCCCCC	19.32	23527152
770	Phosphorylation	YTSPQPGSALSPRQP CCCCCCCCCCCCCCC	32.49	26824392
773	Phosphorylation	PQPGSALSPRQPSGG CCCCCCCCCCCCCCC	20.11	25521595
797	Phosphorylation	QQNSMGSYGPQGSQY CCCCCCCCCCCCCCC	27.39	24704852
797 (in isoform 4)	Phosphorylation	-	27.39	21183079
799 (in isoform 4)	Phosphorylation	-	27.42	29514104
895	Phosphorylation	PGGMNRKTQESAVAM CCCCCHHHHHHHHHH	34.04	22802335
898	Phosphorylation	MNRKTQESAVAMHVA CCHHHHHHHHHHHHH	20.44	22802335
908	Phosphorylation	AMHVAANSIQNRPPG HHHHHHHHHHCCCCC	22.33	22802335
1066	Phosphorylation	VKEIGGLTQVNKNKK HHHHCCCEECCCCHH	33.47	-
1181	Phosphorylation	IPPLPGMSRSNSVGI CCCCCCCCCCCCCCC	38.17	25293948
1183	Phosphorylation	PLPGMSRSNSVGIQD CCCCCCCCCCCCCCC	26.59	25521595
1185	Phosphorylation	PGMSRSNSVGIQDAF CCCCCCCCCCCCCCC	23.98	25521595
1196	Phosphorylation	QDAFPDGSDPTFQKR CCCCCCCCCCCCCCC	48.04	-
1199	Phosphorylation	FPDGSDPTFQKRNSM CCCCCCCCCCCCCCC	43.62	-
1205	Phosphorylation	PTFQKRNSMTPNPGY CCCCCCCCCCCCCCC	28.24	27600695
1207	Phosphorylation	FQKRNSMTPNPGYQP CCCCCCCCCCCCCCC	21.53	27600695
1212	Phosphorylation	SMTPNPGYQPSMNTS CCCCCCCCCCCCCHH	20.64	29550500
1215	Phosphorylation	PNPGYQPSMNTSDMM CCCCCCCCCCHHHHC	14.78	26643407
1218	Phosphorylation	GYQPSMNTSDMMGRM CCCCCCCHHHHCCCC	19.91	26643407
1219	Phosphorylation	YQPSMNTSDMMGRMS CCCCCCHHHHCCCCC	20.64	26643407
1227	Phosphorylation	DMMGRMSYEPNKDPY HHCCCCCCCCCCCCC	26.51	26643407
1236	Phosphorylation	PNKDPYGSMRKAPGS CCCCCCCCCCCCCCC	15.01	-
1277	Methylation	GSVAMGPRQHYPYGG CCCCCCCCCCCCCCC	30.13	24129315
1288	Methylation	PYGGPYDRVRTEPGI CCCCCCCCCCCCCCC	17.61	-
1351	Phosphorylation	FSTQGTPSSSPFPSQ CCCCCCCCCCCCCCH	43.20	23608596
1352	Phosphorylation	STQGTPSSSPFPSQQ CCCCCCCCCCCCCHH	43.14	23608596
1353	Phosphorylation	TQGTPSSSPFPSQQT CCCCCCCCCCCCHHH	34.59	23608596
1536	Phosphorylation	RTDEMLHTDQRANHE CHHHCCCCCCCCCCC	29.84	24704852
1600	Phosphorylation	PRPMENRTSPSKSPF CCCCCCCCCCCCCCC	57.48	28833060
1601	Phosphorylation	RPMENRTSPSKSPFL CCCCCCCCCCCCCCH	24.76	28833060
1603	Phosphorylation	MENRTSPSKSPFLHS CCCCCCCCCCCCHHC	45.60	28833060
1605	Phosphorylation	NRTSPSKSPFLHSGM CCCCCCCCCCHHCCC	25.81	28973931
1610	Phosphorylation	SKSPFLHSGMKMQKA CCCCCHHCCCCCCCC	42.61	28833060
1613	Acetylation	PFLHSGMKMQKAGPP CCHHCCCCCCCCCCC	41.53	-
1661	Phosphorylation	LKQRRRLTMKDIGTP HHHCCCCCHHHCCCH	21.99	28576409
1663	Acetylation	QRRRLTMKDIGTPEA HCCCCCHHHCCCHHH	40.74	23806337
1755	Phosphorylation	PGRFTKVYSPAHTEE CCCCEEEECCCCCHH	15.53	25521595
1756	Phosphorylation	GRFTKVYSPAHTEEE CCCEEEECCCCCHHH	20.71	25521595
1760	Phosphorylation	KVYSPAHTEEEEEEH EEECCCCCHHHHHHC	47.39	25521595
1866	Phosphorylation	SKIELLPSRPYVPCP HCEEECCCCCCCCCC	45.95	28066266
1874	Phosphorylation	RPYVPCPTPPRKHLT CCCCCCCCCCCCCCE	53.28	26824392
1878	Acetylation	PCPTPPRKHLTTVEG CCCCCCCCCCEECCC	49.06	23806337
1881	Phosphorylation	TPPRKHLTTVEGTPG CCCCCCCEECCCCCC	28.63	25619855
1882	Phosphorylation	PPRKHLTTVEGTPGT CCCCCCEECCCCCCC	23.95	25619855
1886	Phosphorylation	HLTTVEGTPGTTEQE CCEECCCCCCCCCCC	12.68	26824392
1889	Phosphorylation	TVEGTPGTTEQEGPP ECCCCCCCCCCCCCC	28.50	25619855
1890	Phosphorylation	VEGTPGTTEQEGPPP CCCCCCCCCCCCCCC	41.40	25619855
1903	Acetylation	PPDGLPEKRITATMD CCCCCCHHHEEEEHH	47.35	23236377
1917	Phosphorylation	DDMLSTRSSTLTDEG HHHHHCCCCCCCHHH	27.97	24704852
1918	Phosphorylation	DMLSTRSSTLTDEGA HHHHCCCCCCCHHHH	24.93	25159016
1919	Phosphorylation	MLSTRSSTLTDEGAK HHHCCCCCCCHHHHH	34.62	25777480
1921	Phosphorylation	STRSSTLTDEGAKSA HCCCCCCCHHHHHHH	31.90	25159016
1927	Phosphorylation	LTDEGAKSAEATKES CCHHHHHHHHHHHHH	30.70	25159016
1931	Phosphorylation	GAKSAEATKESSKFP HHHHHHHHHHHCCCC	27.18	25777480
1942	Phosphorylation	SKFPFGISPAQSHRN CCCCCCCCHHHHHCC	17.98	26824392
1946	Phosphorylation	FGISPAQSHRNIKIL CCCCHHHHHCCEEEE	26.90	28833060
2146	Phosphorylation	FSRLEKLYSTMVRFL HHHHHHHHHHHHHHH	17.11	24068923
2147	Phosphorylation	SRLEKLYSTMVRFLS HHHHHHHHHHHHHHH	22.06	24068923
2148	Phosphorylation	RLEKLYSTMVRFLSD HHHHHHHHHHHHHHC	13.21	24068923
2154	Phosphorylation	STMVRFLSDRKNPVC HHHHHHHHCCCCHHH	32.43	24068923

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ARI1A_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ARI1A_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ARI1A_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
E2F4_MOUSE	E2f4	physical	17255939
E2F5_MOUSE	E2f5	physical	17255939
SMRC1_MOUSE	Smarcc1	physical	17255939
SMCA2_MOUSE	Smarca2	physical	17255939
SMCA4_MOUSE	Smarca4	physical	17255939
HDAC1_MOUSE	Hdac1	physical	17255939
HDAC2_MOUSE	Hdac2	physical	17255939
SIN3A_MOUSE	Sin3a	physical	17255939
SMAD1_MOUSE	Smad1	physical	17255939
RARA_MOUSE	Rara	physical	17363140

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.