E2F4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: E2F4_MOUSE
• UniProt AC: Q8R0K9
• Protein Name: Transcription factor E2F4
• Gene Name: E2f4
• Organism: Mus musculus (Mouse).
• Sequence Length: 410
• Subcellular Localization: Nucleus .
• Protein Description: Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis..
• Protein Sequence: MAEAGPQAPPPPGTPSRHEKSLGLLTTKFVSLLQEAKDGVLDLKLAADTLAVRQKRRIYDITNVLEGIGLIEKKSKNSIQWKGVGPGCNTREIADKLIELKAEIEELQQREQELDQHKVWVQQSIRNVTEDVQNSCLAYVTHEDICRCFAGDTLLAIRAPSGTSLEVPIPEGLNGQKKYQIHLKSMSGPIEVLLVNKEAWSSPPVAVPVPPPDDLLQSPPAVSTPPPLPKPALAQPQESSPPSSPQLTTPTPVLGSTQVSEVACQTSEIAVSGSPGTENKDSGEVSSLPLGLTALDTRPLQSSALLDSSSSSSSSSSSSSSSSSGPNPSTSFEPIKADPTGVLDLPKELSEIFDPTRECMSSELLEELMSSEVFAPLLRLSPPPGDHDYIYNLDESEGVCDLFDVPVLKL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAEAGPQAP ------CCCCCCCCC	18.49	-
14	Phosphorylation	QAPPPPGTPSRHEKS CCCCCCCCCCHHHHH	24.70	26824392
16	Phosphorylation	PPPPGTPSRHEKSLG CCCCCCCCHHHHHHH	46.22	25619855
26	Phosphorylation	EKSLGLLTTKFVSLL HHHHHHHHHHHHHHH	32.74	-
27	Phosphorylation	KSLGLLTTKFVSLLQ HHHHHHHHHHHHHHH	23.58	-
49	Phosphorylation	DLKLAADTLAVRQKR HHHHHHHHHHHHHHH	16.34	22871156
73	Ubiquitination	EGIGLIEKKSKNSIQ HHHCCEEECCCCCCC	56.18	-
218	Phosphorylation	PPDDLLQSPPAVSTP CCHHHHCCCCCCCCC	32.59	26643407
223	Phosphorylation	LQSPPAVSTPPPLPK HCCCCCCCCCCCCCC	36.98	26643407
224	Phosphorylation	QSPPAVSTPPPLPKP CCCCCCCCCCCCCCC	32.96	26643407
315	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
316	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
317	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
318	Phosphorylation	SSSSSSSSSSSSSSG CCCCCCCCCCCCCCC	35.87	-
350	Phosphorylation	LDLPKELSEIFDPTR CCCCHHHHHHCCCCC	29.73	23737553
356	Phosphorylation	LSEIFDPTRECMSSE HHHHCCCCCHHCCHH	40.73	23737553
361	Phosphorylation	DPTRECMSSELLEEL CCCCHHCCHHHHHHH	32.11	25777480
362	Phosphorylation	PTRECMSSELLEELM CCCHHCCHHHHHHHH	12.84	25777480
370	Phosphorylation	ELLEELMSSEVFAPL HHHHHHHCCCCCHHH	35.65	25777480
371	Phosphorylation	LLEELMSSEVFAPLL HHHHHHCCCCCHHHH	24.66	25777480
381	Phosphorylation	FAPLLRLSPPPGDHD CHHHHHCCCCCCCCC	29.00	21149613
389	Phosphorylation	PPPGDHDYIYNLDES CCCCCCCCEEECCCC	11.24	21149613
391	Phosphorylation	PGDHDYIYNLDESEG CCCCCCEEECCCCCC	11.93	26160508
396	Phosphorylation	YIYNLDESEGVCDLF CEEECCCCCCCCCCC	39.04	23649490

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of E2F4_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of E2F4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of E2F4_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RB3GP_MOUSE	Rab3gap1	physical	21701264
ID2_MOUSE	Id2	physical	24573694

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.