INT4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: INT4_MOUSE
• UniProt AC: Q8CIM8
• Protein Name: Integrator complex subunit 4
• Gene Name: Ints4
• Organism: Mus musculus (Mouse).
• Sequence Length: 964
• Subcellular Localization: Nucleus .
• Protein Description: Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex..
• Protein Sequence: MAAHLKKRVYEEFTKVVQQQQEEIATKKLRLTKPSKSAALHIDLCKATSPADALQYLLQFARKPVEAESVEGVVRILLEHYYKENDPSVRLKIASLLGLLSKTAGFSPDCIMDDAINILQNEKSHQVLAQLLDTLLAIGSKLPENQATQVRLVDVACKHLTDTSHGVRNKCLQLLGNLGSLEKSVTKDTEGSAARDVQKIIGDHFSDQDPRVRTAAIKAMLQLHERGLKLHQTIYNQACKLLSDDYEQVRSAAVQLIWVVSQLYPESIVPIPSSNEEIRLVDDAFGKICHMVSDGSWVVRVQAAKLLGSMEQVSSHFLEQTLDKKLMSDLRRKRTAHERAKELYSSGEFSSGRKWGDDAPKEEIDTGAVNLIESGACGAFVHGLEDEMYEVRIAAVEALCMLAQSSPSFAEKCLDFLVDMFNDEIEEVRLQSIHTMRKISNNITLREDQLDTVLAVLEDSSRDIREALHELLCCTNVSTKEGIHLALVELLKNLTKYPTDRDSIWKCLKFLGSRHPTLVLPLVPELLSTHPFFDTAEPDMDDPAYIAVLVLIFNAAKTCPTMPALFSDHTLRHYAYLRDSLSHLVPALRLPGRKLVSSTVPSNITPHEDPSQQFLQQSLERVYSVQHLDPQGAQELLEFTIRDLQRLGELQSELAGVADFSATYLQCQLLLIKALQEKLWNVAAPLYLKQSDLASAAAKQIMEETYKMEFMYSGVENKQVVIIQHMRLQAKALQLIVTARTTRGVDPLFGMCEKFLQEVDFFQRCFIADLPHLQDSFVDKLLDLMPRLMASKPVEVIKILQTMLRQSTFLHLPLPEQIHKASATIIEPAGESDNPLRFTSGLVVALDVDATLEHVQDPQNTVKVQVLYPDGQAQMIHPKPADFRNPGPGRHRLLTQVYLSHTAWTEPCQVEVRLLLAYNSGARIPKSPWLEGSEMSPQVETSIEGTIPFSKPVKVYIMPKPARR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Acetylation	RVYEEFTKVVQQQQE HHHHHHHHHHHHHHH	45.81	19852711
27	Acetylation	QQEEIATKKLRLTKP HHHHHHHHHCCCCCC	40.57	23806337
28	Acetylation	QEEIATKKLRLTKPS HHHHHHHHCCCCCCC	34.19	132979
184	Phosphorylation	NLGSLEKSVTKDTEG CHHHHHHHCCCCCCC	26.16	25159016
186	Phosphorylation	GSLEKSVTKDTEGSA HHHHHHCCCCCCCHH	30.23	25159016
346	Phosphorylation	RAKELYSSGEFSSGR HHHHHHHCCCCCCCC	28.87	25338131
927	Phosphorylation	SGARIPKSPWLEGSE CCCCCCCCCCCCCCC	18.89	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of INT4_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of INT4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of INT4_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
2AAA_HUMAN	PPP2R1A	physical	26496610
INT6_HUMAN	INTS6	physical	26496610
RM04_HUMAN	MRPL4	physical	26496610
INT11_HUMAN	CPSF3L	physical	26496610
INT9_HUMAN	INTS9	physical	26496610
BBX_HUMAN	BBX	physical	26496610
INT12_HUMAN	INTS12	physical	26496610
INT1_HUMAN	INTS1	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.