UCHL5_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UCHL5_MOUSE
• UniProt AC: Q9WUP7
• Protein Name: Ubiquitin carboxyl-terminal hydrolase isozyme L5
• Gene Name: Uchl5
• Organism: Mus musculus (Mouse).
• Sequence Length: 329
• Subcellular Localization: Cytoplasm. Nucleus. Associates with the proteasome 19S subunit in the cytoplasm. Associates with the INO80 complex in the nucleus (By similarity)..
• Protein Description: Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1 (By similarity)..
• Protein Sequence: MSSNAGEWCLMESDPGVFTELIKGFGCRGAQVEEIWSLEPESFEKLKPVHGLIFLFKWQPGEEPAGSVVQDSRLETIFFAKQVINNACATQAIVSVLLNCTHQDVHLGETLSEFKEFSQSFDAAMKGLALSNSDVIRQVHNSFARQQMFEFDTKTPAKEEDAFHFVSYVPVNGRLYELDGLREGPIDLGACNQDDWITAVRPVIEKRIQKYSEGEIRFNLMAIVSDRKMIYEQKIAELQRQLAEEEPMDTDQGSTVLSAIQSEVARNQMLIEEEVQKLKRYKIENIRRKHNYLPFIMELLKTLAEHQQLIPLVEKAKEKQNAKKAQETK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
45	Ubiquitination	LEPESFEKLKPVHGL CCHHHHHHCCCCEEE	60.85	22790023
47	Acetylation	PESFEKLKPVHGLIF HHHHHHCCCCEEEEE	56.94	23806337
47	Succinylation	PESFEKLKPVHGLIF HHHHHHCCCCEEEEE	56.94	-
47	Succinylation	PESFEKLKPVHGLIF HHHHHHCCCCEEEEE	56.94	23806337
118	Phosphorylation	LSEFKEFSQSFDAAM HHHHHHHHHHHHHHH	26.46	29514104
154	Ubiquitination	QMFEFDTKTPAKEED HHEEECCCCCCCHHC	55.12	22790023
158	Acetylation	FDTKTPAKEEDAFHF ECCCCCCCHHCCEEE	63.94	23806337
158	Ubiquitination	FDTKTPAKEEDAFHF ECCCCCCCHHCCEEE	63.94	22790023
191	Glutathionylation	GPIDLGACNQDDWIT CCCCCCCCCCCHHHH	4.45	24333276
206	Ubiquitination	AVRPVIEKRIQKYSE HHHHHHHHHHHHHCC	43.61	22790023
225	Phosphorylation	FNLMAIVSDRKMIYE EEEEEHHHCHHHHHH	26.11	22817900
234	Ubiquitination	RKMIYEQKIAELQRQ HHHHHHHHHHHHHHH	31.76	22790023
276	Ubiquitination	MLIEEEVQKLKRYKI CCCHHHHHHHHCCCH	48.95	27667366
277	Ubiquitination	LIEEEVQKLKRYKIE CCHHHHHHHHCCCHH	62.24	22790023
281	Ubiquitination	EVQKLKRYKIENIRR HHHHHHCCCHHHHHH	18.09	27667366
282	Ubiquitination	VQKLKRYKIENIRRK HHHHHCCCHHHHHHH	47.80	22790023
289	Succinylation	KIENIRRKHNYLPFI CHHHHHHHCCHHHHH	26.76	23806337
289	Succinylation	KIENIRRKHNYLPFI CHHHHHHHCCHHHHH	26.76	-
289	Acetylation	KIENIRRKHNYLPFI CHHHHHHHCCHHHHH	26.76	23806337
315	Ubiquitination	QLIPLVEKAKEKQNA CHHHHHHHHHHHHHH	58.23	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UCHL5_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UCHL5_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UCHL5_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ADRM1_HUMAN	ADRM1	physical	25702872
UBC_HUMAN	UBC	physical	25702872

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.