CXXC5_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CXXC5_MOUSE
• UniProt AC: Q91WA4
• Protein Name: CXXC-type zinc finger protein 5
• Gene Name: Cxxc5
• Organism: Mus musculus (Mouse).
• Sequence Length: 317
• Subcellular Localization: Nucleus. Cytoplasm. Colocalizes with DVL1 in large bodies localized just outside the nuclear membrane..
• Protein Description: May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells. Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis (By similarity). Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen). May repress COX4I2 transactivation induced by CHCHD2 and RBPJ (By similarity)..
• Protein Sequence: MSSLGGGSQDAGGSSSSSNTNSSSGSGQKAGGTDKSTAVAATTAPTSVADDAPPPERRNKSGIISEPLNKSLRRSRPLSHYSSFGSSGGGGSMMGVESADKAAAAAASLLANGHDLAAAMAVDKSNPTSKHKSGAVASLLSKAERATELAAEGQLTLQQFAQSTEMLKRVVQEHLPLMSEAGAGLPDMEAVAGAEALNGQSDFPYLGAFPINPGLFIMTPAGVFLAESALHMAGLAEYPMQGELASAISSGKKKRKRCGMCAPCRRRINCEQCSSCRNRKTGHQICKFRKCEELKKKPSAALEKVMLPSGAAFRWFQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
61	Phosphorylation	PPERRNKSGIISEPL CCHHCCCCCCCCCCC	38.48	27600695
71	Phosphorylation	ISEPLNKSLRRSRPL CCCCCCHHHHHCCCC	26.49	-
81	Phosphorylation	RSRPLSHYSSFGSSG HCCCCCCCCCCCCCC	11.57	29899451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CXXC5_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CXXC5_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CXXC5_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
APC4_HUMAN	ANAPC4	physical	26496610
MCAF1_HUMAN	ATF7IP	physical	26496610
TNC18_HUMAN	TNRC18	physical	26496610
AN13B_HUMAN	ANKRD13B	physical	26496610
TBC16_HUMAN	TBC1D16	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.