AN13B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AN13B_HUMAN
• UniProt AC: Q86YJ7
• Protein Name: Ankyrin repeat domain-containing protein 13B
• Gene Name: ANKRD13B
• Organism: Homo sapiens (Human).
• Sequence Length: 626
• Subcellular Localization: Cell membrane . Late endosome . Early endosome . Interaction with EGFR may enhance association with the cell membrane.
• Protein Description: Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane..
• Protein Sequence: MIPANASARKGPEGKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVSTRDLELVQLVLRYRDYQRVVKRLAGIPVLLEKLRKAQDFYVEMKWEFTSWVPLVSKICPSDTYKVWKSGQNLRVDTTLLGFDHMTWQRGNRSFVFRGQDTSAVVMEIDHDRRVVYTETLALAGQDRELLLAAAQPTEEQVLSRLTAPVVTTQLDTKNISFERNKTGILGWRSEKTEMVNGYEAKVYGASNVELITRTRTEHLSEQHKGKVKGCKTPLQSFLGIAEQHGGPQNGTLITQTLSQANPTAITAEEYFNPNFELGNRDMGRPMELTTKTQKFKAKLWLCEEHPLSLCEQVAPIIDLMAVSNALFAKLRDFITLRLPPGFPVKIEIPIFHILNARITFGNLNGCDEPVPSVRGSPSSETPSPGSDSSSVSSSSSTTSCRGCEISPALFEAPRGYSMMGGQREAATRDDDDDLLQFAIQQSLLEAGSEYDQVTIWEALTNSKPGTHPMSYEGRRQDRSAPPTPQRQPAPPASVPSPRPSSGPGSGGHVFRSYDEQLRLAMELSAQEQEERRRRARQEEEELERILRLSLTEQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MIPANASA -------CCCCCCCC	8.16	22814378
7	Phosphorylation	-MIPANASARKGPEG -CCCCCCCCCCCCCC	28.54	29116813
80	Phosphorylation	DVGRENRSGWTVLQE CCCCCCCCCCCHHHH	50.71	22210691
83	Phosphorylation	RENRSGWTVLQEAVS CCCCCCCCHHHHHHH	18.18	22210691
103	Phosphorylation	LVQLVLRYRDYQRVV HHHHHHHHHHHHHHH	12.04	22210691
106	Phosphorylation	LVLRYRDYQRVVKRL HHHHHHHHHHHHHHH	6.82	22210691
114 (in isoform 2)	Ubiquitination	-	20.22	21890473
146	Ubiquitination	SWVPLVSKICPSDTY CHHHHHHHHCCCCCH	40.63	-
157	Ubiquitination	SDTYKVWKSGQNLRV CCCHHHHHCCCCEEE	47.93	-
175	Phosphorylation	LLGFDHMTWQRGNRS EECCCEEEEECCCEE	18.28	29759185
246	Ubiquitination	VTTQLDTKNISFERN EEEECCCCCCCEECC	52.53	21890473
246 (in isoform 1)	Ubiquitination	-	52.53	21890473
254	Ubiquitination	NISFERNKTGILGWR CCCEECCCCCCEEEE	55.11	-
264	Ubiquitination	ILGWRSEKTEMVNGY CEEEECCCCCEECCE	51.54	-
364	Ubiquitination	RPMELTTKTQKFKAK CCCCCCCHHHHHHHE	43.66	-
452	Phosphorylation	SVRGSPSSETPSPGS CCCCCCCCCCCCCCC	49.20	68730985
456	Phosphorylation	SPSSETPSPGSDSSS CCCCCCCCCCCCCCC	49.68	68730991
461	Phosphorylation	TPSPGSDSSSVSSSS CCCCCCCCCCCCCCC	26.64	68730997
489	Phosphorylation	LFEAPRGYSMMGGQR HHCCCCCCCCCCCCC	8.48	50565337
490	Phosphorylation	FEAPRGYSMMGGQRE HCCCCCCCCCCCCCC	12.71	50565345
556	Phosphorylation	QDRSAPPTPQRQPAP CCCCCCCCCCCCCCC	30.87	23312004

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AN13B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AN13B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AN13B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RLA1_HUMAN	RPLP1	physical	16169070
UBC_HUMAN	UBC	physical	22298428
TERA_HUMAN	VCP	physical	26797118

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.