dbPTM

MCAF1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MCAF1_HUMAN
UniProt AC	Q6VMQ6
Protein Name	Activating transcription factor 7-interacting protein 1
Gene Name	ATF7IP
Organism	Homo sapiens (Human).
Sequence Length	1270
Subcellular Localization	Nucleus .
Protein Description	Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. Required to stimulate histone methyltransferase activity of SETDB1 and facilitate the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells..
Protein Sequence	MDSLEEPQKKVFKARKTMRVSDRQQLEAVYKVKEELLKTDVKLLNGNHENGDLDPTSPLENMDYIKDKEEVNGIEEICFDPEGSKAEWKETPCILSVNVKNKQDDDLNCEPLSPHNITPEPVSKLPAEPVSGDPAPGDLDAGDPASGVLASGDSTSGDPTSSEPSSSDAASGDATSGDAPSGDVSPGDATSGDATADDLSSGDPTSSDPIPGEPVPVEPISGDCAADDIASSEITSVDLASGAPASTDPASDDLASGDLSSSELASDDLATGELASDELTSESTFDRTFEPKSVPVCEPVPEIDNIEPSSNKDDDFLEKNGADEKLEQIQSKDSLDEKNKADNNIDANEETLETDDTTICSDRPPENEKKVEEDIITELALGEDAISSSMEIDQGEKNEDETSADLVETINENVIEDNKSENILENTDSMETDEIIPILEKLAPSEDELTCFSKTSLLPIDETNPDLEEKMESSFGSPSKQESSESLPKEAFLVLSDEEDISGEKDESEVISQNETCSPAEVESNEKDNKPEEEEQVIHEDDERPSEKNEFSRRKRSKSEDMDNVQSKRRRYMEEEYEAEFQVKITAKGDINQKLQKVIQWLLEEKLCALQCAVFDKTLAELKTRVEKIECNKRHKTVLTELQAKIARLTKRFEAAKEDLKKRHEHPPNPPVSPGKTVNDVNSNNNMSYRNAGTVRQMLESKRNVSESAPPSFQTPVNTVSSTNLVTPPAVVSSQPKLQTPVTSGSLTATSVLPAPNTATVVATTQVPSGNPQPTISLQPLPVILHVPVAVSSQPQLLQSHPGTLVTNQPSGNVEFISVQSPPTVSGLTKNPVSLPSLPNPTKPNNVPSVPSPSIQRNPTASAAPLGTTLAVQAVPTAHSIVQATRTSLPTVGPSGLYSPSTNRGPIQMKIPISAFSTSSAAEQNSNTTPRIENQTNKTIDASVSKKAADSTSQCGKATGSDSSGVIDLTMDDEESGASQDPKKLNHTPVSTMSSSQPVSRPLQPIQPAPPLQPSGVPTSGPSQTTIHLLPTAPTTVNVTHRPVTQVTTRLPVPRAPANHQVVYTTLPAPPAQAPLRGTVMQAPAVRQVNPQNSVTVRVPQTTTYVVNNGLTLGSTGPQLTVHHRPPQVHTEPPRPVHPAPLPEAPQPQRLPPEAASTSLPQKPHLKLARVQSQNGIVLSWSVLEVDRSCATVDSYHLYAYHEEPSATVPSQWKKIGEVKALPLPMACTLTQFVSGSKYYFAVRAKDIYGRFGPFCDPQSTDVISSTQSS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDSLEEPQ -------CCCCHHHH	36.27	22814378
3	Phosphorylation	-----MDSLEEPQKK -----CCCCHHHHHH	49.92	24719451
17	Phosphorylation	KVFKARKTMRVSDRQ HHHHHHHHCCCCCHH	12.50	27067055
21	Phosphorylation	ARKTMRVSDRQQLEA HHHHCCCCCHHHHHH	19.40	27067055
30	Phosphorylation	RQQLEAVYKVKEELL HHHHHHHHHHHHHHH	19.67	27067055
33	Sumoylation	LEAVYKVKEELLKTD HHHHHHHHHHHHHCC	41.12	-
33	Sumoylation	LEAVYKVKEELLKTD HHHHHHHHHHHHHCC	41.12	28112733
33	Ubiquitination	LEAVYKVKEELLKTD HHHHHHHHHHHHHCC	41.12	-
56	Phosphorylation	ENGDLDPTSPLENMD CCCCCCCCCCCCCCH	42.52	30266825
57	Phosphorylation	NGDLDPTSPLENMDY CCCCCCCCCCCCCHH	32.64	30266825
64	Phosphorylation	SPLENMDYIKDKEEV CCCCCCHHCCCHHHH	10.09	23403867
84	Phosphorylation	ICFDPEGSKAEWKET EEECCCCCCCCCCCC	27.34	27251275
113	Phosphorylation	DLNCEPLSPHNITPE CCCCCCCCCCCCCCC	34.52	29255136
118	Phosphorylation	PLSPHNITPEPVSKL CCCCCCCCCCCHHCC	27.24	22167270
123	Phosphorylation	NITPEPVSKLPAEPV CCCCCCHHCCCCCCC	38.91	30278072
131	Phosphorylation	KLPAEPVSGDPAPGD CCCCCCCCCCCCCCC	48.47	26074081
293	Phosphorylation	DRTFEPKSVPVCEPV CCCCCCCCCCCCCCC	42.23	25159151
309	Phosphorylation	EIDNIEPSSNKDDDF CCCCCCCCCCCCHHH	33.48	27251275
310	Phosphorylation	IDNIEPSSNKDDDFL CCCCCCCCCCCHHHH	59.62	27690223
332	Acetylation	KLEQIQSKDSLDEKN HHHHHHCCCCCCHHH	34.65	20167786
334	Phosphorylation	EQIQSKDSLDEKNKA HHHHCCCCCCHHHHH	41.26	25849741
351	Phosphorylation	NIDANEETLETDDTT CCCCCHHHHCCCCCC	24.58	-
402	Phosphorylation	GEKNEDETSADLVET CCCCCCCCCHHHHHH	41.35	25627689
403	Phosphorylation	EKNEDETSADLVETI CCCCCCCCHHHHHHH	20.10	25159151
420	Phosphorylation	NVIEDNKSENILENT HHHCCCCCCCHHHCC	41.97	23403867
427	Phosphorylation	SENILENTDSMETDE CCCHHHCCCCCCHHH	21.78	25849741
429	Phosphorylation	NILENTDSMETDEII CHHHCCCCCCHHHHH	19.24	28102081
432	Phosphorylation	ENTDSMETDEIIPIL HCCCCCCHHHHHHHH	30.23	26657352
445	Phosphorylation	ILEKLAPSEDELTCF HHHHHCCCCCCCCEE	52.66	23401153
450	Phosphorylation	APSEDELTCFSKTSL CCCCCCCCEEECCCC	14.95	27794612
453	Phosphorylation	EDELTCFSKTSLLPI CCCCCEEECCCCEEC	36.85	23403867
455	Phosphorylation	ELTCFSKTSLLPIDE CCCEEECCCCEECCC	24.33	27732954
456	Phosphorylation	LTCFSKTSLLPIDET CCEEECCCCEECCCC	31.48	27732954
463	Phosphorylation	SLLPIDETNPDLEEK CCEECCCCCCCHHHH	48.59	23401153
473	Phosphorylation	DLEEKMESSFGSPSK CHHHHHHHHCCCCCC	27.71	29255136
474	Phosphorylation	LEEKMESSFGSPSKQ HHHHHHHHCCCCCCC	21.96	29255136
477	Phosphorylation	KMESSFGSPSKQESS HHHHHCCCCCCCCCC	24.80	19664994
479	Phosphorylation	ESSFGSPSKQESSES HHHCCCCCCCCCCCC	48.98	29255136
483	Phosphorylation	GSPSKQESSESLPKE CCCCCCCCCCCCCCE	36.59	30266825
484	Phosphorylation	SPSKQESSESLPKEA CCCCCCCCCCCCCEE	30.38	30266825
486	Phosphorylation	SKQESSESLPKEAFL CCCCCCCCCCCEEEE	52.50	29255136
496	Phosphorylation	KEAFLVLSDEEDISG CEEEEEECCCCCCCC	35.18	19664994
496 (in isoform 2)	Phosphorylation	-	35.18	26471730
496 (in isoform 5)	Phosphorylation	-	35.18	26471730
502	Phosphorylation	LSDEEDISGEKDESE ECCCCCCCCCCCHHH	53.90	29255136
502 (in isoform 2)	Phosphorylation	-	53.90	26471730
502 (in isoform 5)	Phosphorylation	-	53.90	26471730
508	Phosphorylation	ISGEKDESEVISQNE CCCCCCHHHCCCCCC	47.50	30576142
508 (in isoform 2)	Phosphorylation	-	47.50	26471730
508 (in isoform 5)	Phosphorylation	-	47.50	26471730
512	Phosphorylation	KDESEVISQNETCSP CCHHHCCCCCCCCCH	31.93	22777824
512 (in isoform 2)	Phosphorylation	-	31.93	22617229
512 (in isoform 5)	Phosphorylation	-	31.93	22617229
516	Phosphorylation	EVISQNETCSPAEVE HCCCCCCCCCHHHHH	26.32	22777824
516 (in isoform 2)	Phosphorylation	-	26.32	25159151
516 (in isoform 5)	Phosphorylation	-	26.32	25159151
518	Phosphorylation	ISQNETCSPAEVESN CCCCCCCCHHHHHCC	34.27	25159151
518 (in isoform 2)	Phosphorylation	-	34.27	28985074
518 (in isoform 5)	Phosphorylation	-	34.27	28985074
524	Phosphorylation	CSPAEVESNEKDNKP CCHHHHHCCCCCCCC	56.30	30175587
546	Phosphorylation	HEDDERPSEKNEFSR CCCCCCHHHHCHHHH	68.38	24247654
548	Ubiquitination	DDERPSEKNEFSRRK CCCCHHHHCHHHHHH	67.14	-
557	Phosphorylation	EFSRRKRSKSEDMDN HHHHHHHHCCHHHHH	43.50	29255136
558	Sumoylation	FSRRKRSKSEDMDNV HHHHHHHCCHHHHHH	62.99	-
558	Sumoylation	FSRRKRSKSEDMDNV HHHHHHHCCHHHHHH	62.99	28112733
559	Phosphorylation	SRRKRSKSEDMDNVQ HHHHHHCCHHHHHHH	39.82	29255136
567	Phosphorylation	EDMDNVQSKRRRYME HHHHHHHHHHHHHHH	24.69	23403867
568	Ubiquitination	DMDNVQSKRRRYMEE HHHHHHHHHHHHHHH	32.60	-
576	Ubiquitination	RRRYMEEEYEAEFQV HHHHHHHHHHEEEEE	35.05	-
577	Phosphorylation	RRYMEEEYEAEFQVK HHHHHHHHHEEEEEE	24.58	30576142
588	Ubiquitination	FQVKITAKGDINQKL EEEEEEECCCHHHHH	48.76	-
594	Ubiquitination	AKGDINQKLQKVIQW ECCCHHHHHHHHHHH	48.69	-
596	Ubiquitination	GDINQKLQKVIQWLL CCHHHHHHHHHHHHH	45.03	-
596 (in isoform 2)	Ubiquitination	-	45.03	21890473
597	Ubiquitination	DINQKLQKVIQWLLE CHHHHHHHHHHHHHH	52.31	21890473
597 (in isoform 1)	Ubiquitination	-	52.31	21890473
602	Ubiquitination	LQKVIQWLLEEKLCA HHHHHHHHHHHHHHH	2.18	-
605	Ubiquitination	VIQWLLEEKLCALQC HHHHHHHHHHHHHHH	51.83	-
617	Ubiquitination	LQCAVFDKTLAELKT HHHHHHHHHHHHHHH	33.69	-
623	Ubiquitination	DKTLAELKTRVEKIE HHHHHHHHHHHHHHH	26.28	-
628	Ubiquitination	ELKTRVEKIECNKRH HHHHHHHHHHCCHHH	40.73	-
636	Ubiquitination	IECNKRHKTVLTELQ HHCCHHHHHHHHHHH	44.34	-
644	Ubiquitination	TVLTELQAKIARLTK HHHHHHHHHHHHHHH	20.18	-
644 (in isoform 2)	Ubiquitination	-	20.18	21890473
645	Ubiquitination	VLTELQAKIARLTKR HHHHHHHHHHHHHHH	24.76	2189047
645 (in isoform 1)	Ubiquitination	-	24.76	21890473
653	Ubiquitination	IARLTKRFEAAKEDL HHHHHHHHHHHHHHH	8.80	-
673	Phosphorylation	HPPNPPVSPGKTVND CCCCCCCCCCCCCCC	33.44	29255136
677	Phosphorylation	PPVSPGKTVNDVNSN CCCCCCCCCCCCCCC	30.38	28464451
694	Phosphorylation	MSYRNAGTVRQMLES CCCCCHHHHHHHHHH	15.31	26853621
701	Phosphorylation	TVRQMLESKRNVSES HHHHHHHHCCCCCCC	32.71	-
702	Sumoylation	VRQMLESKRNVSESA HHHHHHHCCCCCCCC	38.32	-
702	Sumoylation	VRQMLESKRNVSESA HHHHHHHCCCCCCCC	38.32	-
708	O-linked_Glycosylation	SKRNVSESAPPSFQT HCCCCCCCCCCCCCC	38.27	30059200
715	O-linked_Glycosylation	SAPPSFQTPVNTVSS CCCCCCCCCCCCCCC	27.48	30059200
719	Phosphorylation	SFQTPVNTVSSTNLV CCCCCCCCCCCCCCC	23.23	24114839
721	Phosphorylation	QTPVNTVSSTNLVTP CCCCCCCCCCCCCCC	29.43	24114839
723	O-linked_Glycosylation	PVNTVSSTNLVTPPA CCCCCCCCCCCCCCE	25.68	30059200
723	Phosphorylation	PVNTVSSTNLVTPPA CCCCCCCCCCCCCCE	25.68	24114839
727	Phosphorylation	VSSTNLVTPPAVVSS CCCCCCCCCCEEECC	27.07	24114839
792	O-linked_Glycosylation	LHVPVAVSSQPQLLQ EEEEEEECCCCHHHH	17.33	30059200
793	O-linked_Glycosylation	HVPVAVSSQPQLLQS EEEEEECCCCHHHHC	39.00	30059200
821	Phosphorylation	VEFISVQSPPTVSGL EEEEEECCCCCCCCC	30.59	26074081
824	Phosphorylation	ISVQSPPTVSGLTKN EEECCCCCCCCCCCC	30.59	26074081
829	Phosphorylation	PPTVSGLTKNPVSLP CCCCCCCCCCCCCCC	32.09	25137130
834	O-linked_Glycosylation	GLTKNPVSLPSLPNP CCCCCCCCCCCCCCC	35.50	30059200
834	Phosphorylation	GLTKNPVSLPSLPNP CCCCCCCCCCCCCCC	35.50	21406692
837	O-linked_Glycosylation	KNPVSLPSLPNPTKP CCCCCCCCCCCCCCC	62.85	30059200
837	Phosphorylation	KNPVSLPSLPNPTKP CCCCCCCCCCCCCCC	62.85	21406692
842	O-linked_Glycosylation	LPSLPNPTKPNNVPS CCCCCCCCCCCCCCC	66.81	30059200
842	Phosphorylation	LPSLPNPTKPNNVPS CCCCCCCCCCCCCCC	66.81	29978859
843	Acetylation	PSLPNPTKPNNVPSV CCCCCCCCCCCCCCC	47.18	26051181
849	O-linked_Glycosylation	TKPNNVPSVPSPSIQ CCCCCCCCCCCCCCC	42.23	30059200
849	Phosphorylation	TKPNNVPSVPSPSIQ CCCCCCCCCCCCCCC	42.23	21082442
852	Phosphorylation	NNVPSVPSPSIQRNP CCCCCCCCCCCCCCC	29.17	25159151
854	O-linked_Glycosylation	VPSVPSPSIQRNPTA CCCCCCCCCCCCCCC	35.37	30059200
854	Phosphorylation	VPSVPSPSIQRNPTA CCCCCCCCCCCCCCC	35.37	30576142
869	O-linked_Glycosylation	SAAPLGTTLAVQAVP CCCCCCCEEEEEECC	15.77	30059200
877	O-linked_Glycosylation	LAVQAVPTAHSIVQA EEEEECCCHHHHHHH	30.33	30059200
885	O-linked_Glycosylation	AHSIVQATRTSLPTV HHHHHHHHHCCCCCC	19.86	30059200
887	O-linked_Glycosylation	SIVQATRTSLPTVGP HHHHHHHCCCCCCCC	30.20	30059200
887	Phosphorylation	SIVQATRTSLPTVGP HHHHHHHCCCCCCCC	30.20	20068231
888	Phosphorylation	IVQATRTSLPTVGPS HHHHHHCCCCCCCCC	29.12	20068231
891	Phosphorylation	ATRTSLPTVGPSGLY HHHCCCCCCCCCCCC	43.31	20068231
895	Phosphorylation	SLPTVGPSGLYSPST CCCCCCCCCCCCCCC	35.19	26657352
898	Phosphorylation	TVGPSGLYSPSTNRG CCCCCCCCCCCCCCC	23.28	22199227
899	Phosphorylation	VGPSGLYSPSTNRGP CCCCCCCCCCCCCCC	19.88	25159151
901	Phosphorylation	PSGLYSPSTNRGPIQ CCCCCCCCCCCCCEE	32.16	25159151
902	Phosphorylation	SGLYSPSTNRGPIQM CCCCCCCCCCCCEEE	32.11	22199227
910	Sumoylation	NRGPIQMKIPISAFS CCCCEEEEEEECCCC	29.02	28112733
914	O-linked_Glycosylation	IQMKIPISAFSTSSA EEEEEEECCCCCCCH	20.22	30059200
918	O-linked_Glycosylation	IPISAFSTSSAAEQN EEECCCCCCCHHHHC	21.90	30059200
918	Phosphorylation	IPISAFSTSSAAEQN EEECCCCCCCHHHHC	21.90	28348404
919	O-linked_Glycosylation	PISAFSTSSAAEQNS EECCCCCCCHHHHCC	19.44	30059200
919	Phosphorylation	PISAFSTSSAAEQNS EECCCCCCCHHHHCC	19.44	28348404
920	O-linked_Glycosylation	ISAFSTSSAAEQNSN ECCCCCCCHHHHCCC	31.42	30059200
920	Phosphorylation	ISAFSTSSAAEQNSN ECCCCCCCHHHHCCC	31.42	28348404
926	O-linked_Glycosylation	SSAAEQNSNTTPRIE CCHHHHCCCCCCCCC	34.94	30059200
926	Phosphorylation	SSAAEQNSNTTPRIE CCHHHHCCCCCCCCC	34.94	25850435
928	Phosphorylation	AAEQNSNTTPRIENQ HHHHCCCCCCCCCCC	37.69	25850435
929	O-linked_Glycosylation	AEQNSNTTPRIENQT HHHCCCCCCCCCCCC	18.15	30059200
929	Phosphorylation	AEQNSNTTPRIENQT HHHCCCCCCCCCCCC	18.15	25850435
936	Phosphorylation	TPRIENQTNKTIDAS CCCCCCCCCCEEEHH	50.71	-
938	Acetylation	RIENQTNKTIDASVS CCCCCCCCEEEHHHH	50.69	23954790
938	Sumoylation	RIENQTNKTIDASVS CCCCCCCCEEEHHHH	50.69	28112733
938	Ubiquitination	RIENQTNKTIDASVS CCCCCCCCEEEHHHH	50.69	-
943	Phosphorylation	TNKTIDASVSKKAAD CCCEEEHHHHHHHCC	24.15	22964224
945	Phosphorylation	KTIDASVSKKAADST CEEEHHHHHHHCCCC	26.41	22964224
946	Acetylation	TIDASVSKKAADSTS EEEHHHHHHHCCCCC	44.25	-
951	Phosphorylation	VSKKAADSTSQCGKA HHHHHCCCCCCCCCC	25.82	-
970	Phosphorylation	SSGVIDLTMDDEESG CCCEEEEEECCCCCC	18.14	-
976	Phosphorylation	LTMDDEESGASQDPK EEECCCCCCCCCCCC	37.30	-
979	Phosphorylation	DDEESGASQDPKKLN CCCCCCCCCCCCCCC	38.35	-
988	Phosphorylation	DPKKLNHTPVSTMSS CCCCCCCCCCCCCCC	25.06	27732954
991	O-linked_Glycosylation	KLNHTPVSTMSSSQP CCCCCCCCCCCCCCC	21.42	30059200
991	Phosphorylation	KLNHTPVSTMSSSQP CCCCCCCCCCCCCCC	21.42	27732954
992	O-linked_Glycosylation	LNHTPVSTMSSSQPV CCCCCCCCCCCCCCC	22.70	30059200
992	Phosphorylation	LNHTPVSTMSSSQPV CCCCCCCCCCCCCCC	22.70	27732954
996	Phosphorylation	PVSTMSSSQPVSRPL CCCCCCCCCCCCCCC	31.06	-
1064	Phosphorylation	PANHQVVYTTLPAPP CCCCEEEEEEECCCC	8.64	28796482
1065	Phosphorylation	ANHQVVYTTLPAPPA CCCEEEEEEECCCCC	15.39	28796482
1066	Phosphorylation	NHQVVYTTLPAPPAQ CCEEEEEEECCCCCC	17.04	28796482
1087	Dimethylation	VMQAPAVRQVNPQNS EEECCCEEECCCCCC	36.51	-
1087	Methylation	VMQAPAVRQVNPQNS EEECCCEEECCCCCC	36.51	-
1096	Phosphorylation	VNPQNSVTVRVPQTT CCCCCCEEEECCCCE	11.47	24719451
1098	Methylation	PQNSVTVRVPQTTTY CCCCEEEECCCCEEE	25.65	-
1102	Phosphorylation	VTVRVPQTTTYVVNN EEEECCCCEEEEEEC	18.29	24043423
1103	Phosphorylation	TVRVPQTTTYVVNNG EEECCCCEEEEEECC	15.75	24043423
1104	Phosphorylation	VRVPQTTTYVVNNGL EECCCCEEEEEECCE	20.08	24043423
1105	Phosphorylation	RVPQTTTYVVNNGLT ECCCCEEEEEECCEE	10.58	24043423
1112	Phosphorylation	YVVNNGLTLGSTGPQ EEEECCEECCCCCCC	30.39	24043423
1115	Phosphorylation	NNGLTLGSTGPQLTV ECCEECCCCCCCEEE	33.05	24043423
1116	Phosphorylation	NGLTLGSTGPQLTVH CCEECCCCCCCEEEE	51.59	24043423
1121	Phosphorylation	GSTGPQLTVHHRPPQ CCCCCCEEEECCCCC	16.73	24043423
1131	Phosphorylation	HRPPQVHTEPPRPVH CCCCCCCCCCCCCCC	51.86	24043423
1163	Ubiquitination	ASTSLPQKPHLKLAR HCCCCCCCCCEEEEE	32.25	21890473
1163 (in isoform 1)	Ubiquitination	-	32.25	21890473
1171	Ubiquitination	PHLKLARVQSQNGIV CCEEEEEEECCCCEE	5.51	-
1269	Phosphorylation	DVISSTQSS------ CCHHHCCCC------	37.80	25627689
1270	Phosphorylation	VISSTQSS------- CHHHCCCC-------	34.13	25627689

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MCAF1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MCAF1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MCAF1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MBD1_HUMAN	MBD1	physical	12665582
ERCC3_HUMAN	ERCC3	physical	19106100
ERCC2_HUMAN	ERCC2	physical	19106100
RPB1_HUMAN	POLR2A	physical	19106100
T2EB_HUMAN	GTF2E2	physical	19106100
T2EA_HUMAN	GTF2E1	physical	19106100
MBD1_HUMAN	MBD1	physical	16757475
RTA_EBVB9	BRLF1	physical	16314315
SP1_HUMAN	SP1	physical	16314315
MBD1_HUMAN	MBD1	physical	15691849
SETB1_HUMAN	SETDB1	physical	15691849
SP1_HUMAN	SP1	physical	15691849
RL8_HUMAN	RPL8	physical	22939629
SMAD4_HUMAN	SMAD4	physical	21988832
PML_HUMAN	PML	physical	23935871
SETB1_HUMAN	SETDB1	physical	26344197
AL14E_HUMAN	ARL14EP	physical	28514442
GT2D1_HUMAN	GTF2IRD1	physical	26275350

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MCAF1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-113; THR-118; SER-477;SER-496; SER-518 AND SER-899, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-113; THR-118; SER-473;SER-477 AND SER-899, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-113; SER-496 ANDSER-673, AND MASS SPECTROMETRY.	17081983 [Abstract]