RTA_EBVB9 - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RTA_EBVB9
• UniProt AC: P03209
• Protein Name: Replication and transcription activator
• Gene Name: BRLF1
• Organism: Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4).
• Sequence Length: 605
• Protein Description: Immediate-early transcription factor that controls the initiation of viral lytic gene expression and lytic reactivation from latency. Triggers lytic replication, and initiates a cellular senescence program in epithelial cells. Upregulates human DCR3/TNFRSF6B by directly binding to its receptor..
• Protein Sequence: MRPKKDGLEDFLRLTPEIKKQLGSLVSDYCNVLNKEFTAGSVEITLRSYKICKAFINEAKAHGREWGGLMATLNICNFWAILRNNRVRRRAENAGNDACSIACPIVMRYVLDHLIVVTDRFFIQAPSNRVMIPATIGTAMYKLLKHSRVRAYTYSKVLGVDRAAIMASGKQVVEHLNRMEKEGLLSSKFKAFCKWVFTYPVLEEMFQTMVSSKTGHLTDDVKDVRALIKTLPRASYSSHAGQRSYVSGVLPACLLSTKSKAVETPILVSGADRMDEELMGNDGGASHTEARYSESGQFHAFTDELESLPSPTMPLKPGAQSADCGDSSSSSSDSGNSDTEQSEREEARAEAPRLRAPKSRRTSRPNRGQTPCPSNAAEPEQPWIAAVHQESDERPIFPHPSKPTFLPPVKRKKGLRDSREGMFLPKPEAGSAISDVFEGREVCQPKRIRPFHPPGSPWANRPLPASLAPTPTGPVHEPVGSLTPAPVPQPLDPAPAVTPEASHLLEDPDEETSQAVKALREMADTVIPQKEEAAICGQMDLSHPPPRGHLDELTTTLESMTEDLNLDSPLTPELNEILDTFLNDECLLHAMHISTGLSIFDTSLF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
19	Sumoylation	LRLTPEIKKQLGSLV HHHCHHHHHHHHHHH	32.57	-
213	Sumoylation	FQTMVSSKTGHLTDD HHHHHHHCCCCCCCC	51.52	-
426	Sumoylation	REGMFLPKPEAGSAI CCCCCCCCCCCCCCC	58.60	-
446	Sumoylation	GREVCQPKRIRPFHP CCCCCCCCCCCCCCC	34.28	-
517	Sumoylation	EETSQAVKALREMAD HHHHHHHHHHHHHHH	44.73	-
530	Sumoylation	ADTVIPQKEEAAICG HHCCCCHHHHHHHHC	52.76	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RTA_EBVB9 !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RTA_EBVB9 !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RTA_EBVB9 !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MCAF1_HUMAN	ATF7IP	physical	16314315
SP1_HUMAN	SP1	physical	16314315
RNF4_HUMAN	RNF4	physical	23504328

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.