| UniProt ID | SGO2_MOUSE | |
|---|---|---|
| UniProt AC | Q7TSY8 | |
| Protein Name | Shugoshin 2 {ECO:0000250|UniProtKB:Q562F6} | |
| Gene Name | Sgo2 {ECO:0000250|UniProtKB:Q562F6} | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 1164 | |
| Subcellular Localization | Nucleus . Chromosome, centromere . Chromosome, centromere, kinetochore . Centromeric localization requires the presence of BUB1 and AUKRB (By similarity). During meiosis I, accumulates at centromeres during diplotene, and colocalizes differentially w | |
| Protein Description | Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation. Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments. Involved in centromeric enrichment of AUKRB in prometaphase.. | |
| Protein Sequence | MEYPGIKVDTVTSGIQRRVKGRIAKTNLNVSLASKIKAKILNNSSIFKISLKHNNRALARALSKEKENSRRITTEKMQLQKEVEKLNFENTFLRLKLNTLNKKLVEIESHVSNDLLTAIEISSLSEFHQGSFLLSATKKQRNSKQCKPAHLPYARVLLTSENDDDDGADDKWQTKCNNRTISKTSPDSTSSVSRQPSSLHQCNLKAFPPKEDNQKTCGSGHLEHTSSVDILPNESHSDQSPKSSLSEMKTAPSPSLRREKLSHGNVTMRKKCVSSTPDILYVTDLDHQPTSSPGSNWNNEIHGHTNETSNNTQRNAECFLDLPSESSSEPDAKRMELVQKNTDSFHFQKTVYDAADMELTATDIGKIVAVSKSKKNQNKKKADCRKETFRKVKGASSDKKRESSKRECKDGSEVGAEEEADAARAERGAGVLDGRGDSEEPNCISSTEQPSQVNTQKKRTLQNSSDQENIQNTKRRQTYTTDEQEETNPFSRHSVKFLQDGKFDLCQKTLHHNLSKPSRQTFVIRKSEKDNLFPNQEDKDTISENLEVTNEFHIDDLSIEANENVCDHETQTMLDLKKSVSAQQNQTKINKTKQKINRRTKIISVMSQVYEDNDKDIHVLEKDNFPFHTQANKETTSGNLESSKEFESPLLFTRDNGSLRDCKTQNVLDLHKQIPDLYPDRNESQISKIPRQKVNRKTEVISGVKCFSNDQGVHCSEKDKSLLLQKDKDFPGTLKDLSEFDTPAFCNKDSAKSCDYKSEMLLGLKKHDPNMQPACQDDSKAGKKLRQKVNRKTEIISKITQIHENDRGSTHDSLNKKLCQKVNISKIISQMNQIYETINEDGNGFKSSIKDCEDIKSCDFGEINSNKKENYDPIQDPCTLVKKTKRKGSCKAGSSLAGAKNRCGLQLTDSSQVQSVPLDSGLRHHPNEADSGPGEQTNLPKMQKQSAGRSLGDAFSVSLGKEGSRPAKAVSKMTPKSKKRKLPLGCSPETHGTVEITPNTDLAKAVDSQQTEKENYLEKEKIAKRKPDFCTKVLKPLSETCSSNIKNSSLDSMCKSSLPLSISSRKTLMLEESSSLESTCIFQVGDAAHEKITTGTRNPHHRTQKSTPGSRTSLVLVDTSSVSDTNPANPENESEGQSSHPMRRKRQCVPLNLTEPSLRSKMRR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 26 | Phosphorylation | VKGRIAKTNLNVSLA HCCCCCCCCCCHHHH | 28576409 | ||
| 31 | Phosphorylation | AKTNLNVSLASKIKA CCCCCCHHHHHHHHH | 28418008 | ||
| 159 | Phosphorylation | PYARVLLTSENDDDD CCEEEEEECCCCCCC | 26745281 | ||
| 160 | Phosphorylation | YARVLLTSENDDDDG CEEEEEECCCCCCCC | 26370283 | ||
| 184 | Phosphorylation | NNRTISKTSPDSTSS CCCEECCCCCCCCCC | 29895711 | ||
| 185 | Phosphorylation | NRTISKTSPDSTSSV CCEECCCCCCCCCCC | 27841257 | ||
| 240 | Phosphorylation | NESHSDQSPKSSLSE CCCCCCCCCCCCHHH | 25266776 | ||
| 250 | Phosphorylation | SSLSEMKTAPSPSLR CCHHHHCCCCCHHHH | 28066266 | ||
| 253 | Phosphorylation | SEMKTAPSPSLRREK HHHCCCCCHHHHHHH | 26745281 | ||
| 255 | Phosphorylation | MKTAPSPSLRREKLS HCCCCCHHHHHHHHC | 28066266 | ||
| 342 | Phosphorylation | MELVQKNTDSFHFQK HHHHHHHCCCCEEEC | 26745281 | ||
| 344 | Phosphorylation | LVQKNTDSFHFQKTV HHHHHCCCCEEECHH | 27600695 | ||
| 373 | Phosphorylation | KIVAVSKSKKNQNKK HHHHCCCCCCCCCCC | 20139300 | ||
| 412 | Phosphorylation | KRECKDGSEVGAEEE CCCCCCCCCCCHHHH | 26370283 | ||
| 455 | Phosphorylation | EQPSQVNTQKKRTLQ CCCHHHCHHHHHHHC | - | ||
| 479 | Phosphorylation | NTKRRQTYTTDEQEE HHCCCCEECCCCCCC | - | ||
| 521 | Phosphorylation | LSKPSRQTFVIRKSE CCCCCCCEEEEEEHH | - | ||
| 600 | Phosphorylation | KQKINRRTKIISVMS HHHHHHHHHHHHHHH | - | ||
| 648 | Phosphorylation | ESSKEFESPLLFTRD CCCCCCCCCEEEECC | 26239621 | ||
| 653 | Phosphorylation | FESPLLFTRDNGSLR CCCCEEEECCCCCHH | 28066266 | ||
| 702 | Phosphorylation | NRKTEVISGVKCFSN CCCCEEEEECEECCC | - | ||
| 721 | Phosphorylation | HCSEKDKSLLLQKDK CCCHHHHHHHHHCCC | 28066266 | ||
| 946 | Phosphorylation | LPKMQKQSAGRSLGD CHHHHHHHHCCCHHH | 24719451 | ||
| 950 | Phosphorylation | QKQSAGRSLGDAFSV HHHHHCCCHHHHHHH | 24719451 | ||
| 993 | Phosphorylation | CSPETHGTVEITPNT CCCCCCCEEEECCCC | 30482847 | ||
| 1038 | Phosphorylation | TKVLKPLSETCSSNI HHHHHHHHHHHHHHC | 28059163 | ||
| 1042 | Phosphorylation | KPLSETCSSNIKNSS HHHHHHHHHHCCCCC | - | ||
| 1052 | Phosphorylation | IKNSSLDSMCKSSLP CCCCCHHHHHHHCCC | 28059163 |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SGO2_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SGO2_MOUSE !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
