CPNE2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CPNE2_HUMAN
• UniProt AC: Q96FN4
• Protein Name: Copine-2 {ECO:0000305}
• Gene Name: CPNE2 {ECO:0000312|HGNC:HGNC:2315}
• Organism: Homo sapiens (Human).
• Sequence Length: 548
• Subcellular Localization: Cytoplasm . Nucleus . Cell membrane . Translocates to the cell membrane and the nucleus in a calcium-dependent manner. Colocalizes with CD2 at the cell membrane.
• Protein Description: Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Exhibits calcium-dependent cell membrane binding properties..
• Protein Sequence: MAHIPSGGAPAAGAAPMGPQYCVCKVELSVSGQNLLDRDVTSKSDPFCVLFTENNGRWIEYDRTETAINNLNPAFSKKFVLDYHFEEVQKLKFALFDQDKSSMRLDEHDFLGQFSCSLGTIVSSKKITRPLLLLNDKPAGKGLITIAAQELSDNRVITLSLAGRRLDKKDLFGKSDPFLEFYKPGDDGKWMLVHRTEVIKYTLDPVWKPFTVPLVSLCDGDMEKPIQVMCYDYDNDGGHDFIGEFQTSVSQMCEARDSVPLEFECINPKKQRKKKNYKNSGIIILRSCKINRDYSFLDYILGGCQLMFTVGIDFTASNGNPLDPSSLHYINPMGTNEYLSAIWAVGQIIQDYDSDKMFPALGFGAQLPPDWKVSHEFAINFNPTNPFCSGVDGIAQAYSACLPHIRFYGPTNFSPIVNHVARFAAQATQQRTATQYFILLIITDGVISDMEETRHAVVQASKLPMSIIIVGVGNADFAAMEFLDGDSRMLRSHTGEEAARDIVQFVPFREFRNAAKETLAKAVLAELPQQVVQYFKHKNLPPTNSEPA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	Phosphorylation	AAPMGPQYCVCKVEL CCCCCCCEEEEEEEE	7.03	20058876
31	Phosphorylation	CKVELSVSGQNLLDR EEEEEEECCCCCCCC	31.14	20058876
90	Ubiquitination	YHFEEVQKLKFALFD ECHHHHHHHHEEEEC	59.84	23000965
92	Ubiquitination	FEEVQKLKFALFDQD HHHHHHHHEEEECCC	35.31	23000965
118	Ubiquitination	LGQFSCSLGTIVSSK HCEEEECHHHHHCCC	9.11	21890473
118	Ubiquitination	LGQFSCSLGTIVSSK HCEEEECHHHHHCCC	9.11	21890473
160	Phosphorylation	DNRVITLSLAGRRLD CCCEEEEEECCCCCC	13.92	24719451
174	Ubiquitination	DKKDLFGKSDPFLEF CHHHHCCCCCCCEEE	44.33	29967540
287	Phosphorylation	SGIIILRSCKINRDY CCEEEEECCCCCCCC	19.13	22964224
408	Phosphorylation	CLPHIRFYGPTNFSP HCCCEEEECCCCCHH	16.61	28152594
411	Phosphorylation	HIRFYGPTNFSPIVN CEEEECCCCCHHHHH	44.53	28152594
414	Phosphorylation	FYGPTNFSPIVNHVA EECCCCCHHHHHHHH	18.78	28152594
428	Phosphorylation	ARFAAQATQQRTATQ HHHHHHHHHHHHHHH	17.10	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CPNE2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CPNE2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CPNE2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PPP5_MOUSE	Ppp5c	physical	12522145
SKIL_MOUSE	Skil	physical	12522145
BCOR_MOUSE	Bcor	physical	12522145
UBE2O_MOUSE	Ube2o	physical	12522145
RADI_MOUSE	Rdx	physical	12522145
ACTB_MOUSE	Actb	physical	12522145
MYCB2_MOUSE	Mycbp2	physical	12522145
S10AG_HUMAN	S100A16	physical	22939629
PDCD6_MOUSE	Pdcd6	physical	12522145
TRI27_HUMAN	TRIM27	physical	21516116
HIP1_HUMAN	HIP1	physical	28514442
RABE2_HUMAN	RABEP2	physical	28514442
UBP24_HUMAN	USP24	physical	28514442
AFAD_HUMAN	MLLT4	physical	28514442
DNM1L_HUMAN	DNM1L	physical	28514442
RABX5_HUMAN	RABGEF1	physical	28514442
NEK1_HUMAN	NEK1	physical	28514442
PIBF1_HUMAN	PIBF1	physical	28514442
TXLNG_HUMAN	TXLNG	physical	28514442
COE3_HUMAN	EBF3	physical	28514442
TXLNA_HUMAN	TXLNA	physical	28514442
OSBL3_HUMAN	OSBPL3	physical	28514442
ZDBF2_HUMAN	ZDBF2	physical	28514442
DDI2_HUMAN	DDI2	physical	28514442
MYZAP_HUMAN	POLR2M	physical	28514442
GRL1A_HUMAN	POLR2M	physical	28514442
GL1AD_HUMAN	POLR2M	physical	28514442
NUP58_HUMAN	NUPL1	physical	28514442
RPAP2_HUMAN	RPAP2	physical	28514442
NEK3_HUMAN	NEK3	physical	28514442
INT3_HUMAN	INTS3	physical	28514442
NUP54_HUMAN	NUP54	physical	28514442
RPB11_HUMAN	POLR2J	physical	28514442
RPB4_HUMAN	POLR2D	physical	28514442
RPB1_HUMAN	POLR2A	physical	28514442
EIF3H_HUMAN	EIF3H	physical	28514442
SPT5H_HUMAN	SUPT5H	physical	28514442
HDGF_HUMAN	HDGF	physical	28514442
EIF3A_HUMAN	EIF3A	physical	28514442
NOC2L_HUMAN	NOC2L	physical	28514442
ZN318_HUMAN	ZNF318	physical	28514442
RN138_HUMAN	RNF138	physical	28514442
RPB9_HUMAN	POLR2I	physical	28514442
NUP62_HUMAN	NUP62	physical	28514442
RPB2_HUMAN	POLR2B	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.