| UniProt ID | HDGF_HUMAN | |
|---|---|---|
| UniProt AC | P51858 | |
| Protein Name | Hepatoma-derived growth factor | |
| Gene Name | HDGF | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 240 | |
| Subcellular Localization | Cytoplasm. Nucleus. | |
| Protein Description | Heparin-binding protein, with mitogenic activity for fibroblasts. Acts as a transcriptional repressor.. | |
| Protein Sequence | MSRSNRQKEYKCGDLVFAKMKGYPHWPARIDEMPEAAVKSTANKYQVFFFGTHETAFLGPKDLFPYEESKEKFGKPNKRKGFSEGLWEIENNPTVKASGYQSSQKKSCVEEPEPEPEAAEGDGDKKGNAEGSSDEEGKLVIDEPAKEKNEKGALKRRAGDLLEDSPKRPKEAENPEGEEKEAATLEVERPLPMEVEKNSTPSEPGSGRGPPQEEEEEEDEEEEATKEDAEAPGIRDHESL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 11 | Ubiquitination | SNRQKEYKCGDLVFA CHHCCCCCCCCEEHH | 32.60 | 21890473 | |
| 11 | Sumoylation | SNRQKEYKCGDLVFA CHHCCCCCCCCEEHH | 32.60 | - | |
| 11 | Sumoylation | SNRQKEYKCGDLVFA CHHCCCCCCCCEEHH | 32.60 | - | |
| 12 | S-palmitoylation | NRQKEYKCGDLVFAK HHCCCCCCCCEEHHH | 5.12 | 29575903 | |
| 12 | Glutathionylation | NRQKEYKCGDLVFAK HHCCCCCCCCEEHHH | 5.12 | 22555962 | |
| 19 | Acetylation | CGDLVFAKMKGYPHW CCCEEHHHCCCCCCC | 29.67 | 25953088 | |
| 21 | Ubiquitination | DLVFAKMKGYPHWPA CEEHHHCCCCCCCCC | 55.36 | - | |
| 23 | Phosphorylation | VFAKMKGYPHWPARI EHHHCCCCCCCCCCH | 6.09 | 25159151 | |
| 27 (in isoform 3) | Phosphorylation | - | 14.50 | 22496350 | |
| 33 | Sulfoxidation | WPARIDEMPEAAVKS CCCCHHHCCHHHHHH | 3.01 | 21406390 | |
| 37 | Acetylation | IDEMPEAAVKSTANK HHHCCHHHHHHHCCC | 13.96 | 19608861 | |
| 39 | Ubiquitination | EMPEAAVKSTANKYQ HCCHHHHHHHCCCEE | 37.04 | 21906983 | |
| 39 | Acetylation | EMPEAAVKSTANKYQ HCCHHHHHHHCCCEE | 37.04 | 21339330 | |
| 44 | Acetylation | AVKSTANKYQVFFFG HHHHHCCCEEEEEEE | 34.30 | 19608861 | |
| 45 | Phosphorylation | VKSTANKYQVFFFGT HHHHCCCEEEEEEEC | 15.09 | - | |
| 60 | Acetylation | HETAFLGPKDLFPYE CCCCCCCHHHCCCHH | 29.18 | 19608861 | |
| 66 | Phosphorylation | GPKDLFPYEESKEKF CHHHCCCHHHHHHHH | 25.62 | 28152594 | |
| 69 | Phosphorylation | DLFPYEESKEKFGKP HCCCHHHHHHHHCCC | 33.89 | 28152594 | |
| 70 | Ubiquitination | LFPYEESKEKFGKPN CCCHHHHHHHHCCCC | 69.10 | - | |
| 70 | Acetylation | LFPYEESKEKFGKPN CCCHHHHHHHHCCCC | 69.10 | 26051181 | |
| 72 | Acetylation | PYEESKEKFGKPNKR CHHHHHHHHCCCCCC | 64.25 | 25953088 | |
| 73 | Ubiquitination | YEESKEKFGKPNKRK HHHHHHHHCCCCCCC | 18.66 | 21890473 | |
| 73 | Ubiquitination | YEESKEKFGKPNKRK HHHHHHHHCCCCCCC | 18.66 | 21890473 | |
| 80 | Sumoylation | FGKPNKRKGFSEGLW HCCCCCCCCCCCCCE | 66.95 | - | |
| 80 | Sumoylation | FGKPNKRKGFSEGLW HCCCCCCCCCCCCCE | 66.95 | 28112733 | |
| 80 | Acetylation | FGKPNKRKGFSEGLW HCCCCCCCCCCCCCE | 66.95 | 27452117 | |
| 80 | Ubiquitination | FGKPNKRKGFSEGLW HCCCCCCCCCCCCCE | 66.95 | 21890473 | |
| 83 | Phosphorylation | PNKRKGFSEGLWEIE CCCCCCCCCCCEEEC | 39.15 | 30624053 | |
| 94 | Phosphorylation | WEIENNPTVKASGYQ EEECCCCCCCCCCCC | 36.44 | 26074081 | |
| 96 | Ubiquitination | IENNPTVKASGYQSS ECCCCCCCCCCCCCC | 39.03 | - | |
| 96 | Ubiquitination | IENNPTVKASGYQSS ECCCCCCCCCCCCCC | 39.03 | 21890473 | |
| 96 | Sumoylation | IENNPTVKASGYQSS ECCCCCCCCCCCCCC | 39.03 | - | |
| 98 | Phosphorylation | NNPTVKASGYQSSQK CCCCCCCCCCCCCCC | 32.11 | 26074081 | |
| 99 (in isoform 3) | Phosphorylation | - | 29.38 | 24719451 | |
| 100 | Phosphorylation | PTVKASGYQSSQKKS CCCCCCCCCCCCCCC | 11.61 | 26074081 | |
| 102 | Phosphorylation | VKASGYQSSQKKSCV CCCCCCCCCCCCCCC | 26.67 | 25849741 | |
| 103 | Phosphorylation | KASGYQSSQKKSCVE CCCCCCCCCCCCCCC | 30.41 | 25849741 | |
| 105 | Ubiquitination | SGYQSSQKKSCVEEP CCCCCCCCCCCCCCC | 48.91 | - | |
| 105 | Acetylation | SGYQSSQKKSCVEEP CCCCCCCCCCCCCCC | 48.91 | 25953088 | |
| 106 | Acetylation | GYQSSQKKSCVEEPE CCCCCCCCCCCCCCC | 41.26 | 30585617 | |
| 106 | Ubiquitination | GYQSSQKKSCVEEPE CCCCCCCCCCCCCCC | 41.26 | - | |
| 107 | Phosphorylation | YQSSQKKSCVEEPEP CCCCCCCCCCCCCCC | 30.36 | 23401153 | |
| 108 | Glutathionylation | QSSQKKSCVEEPEPE CCCCCCCCCCCCCCC | 6.49 | 22555962 | |
| 118 (in isoform 3) | Phosphorylation | - | 22.87 | 24719451 | |
| 119 (in isoform 3) | Phosphorylation | - | 21.46 | 24719451 | |
| 123 (in isoform 3) | Phosphorylation | - | 60.54 | 24719451 | |
| 125 | Acetylation | AAEGDGDKKGNAEGS HHCCCCCCCCCCCCC | 69.02 | 23236377 | |
| 126 | Ubiquitination | AEGDGDKKGNAEGSS HCCCCCCCCCCCCCC | 63.24 | - | |
| 132 | Phosphorylation | KKGNAEGSSDEEGKL CCCCCCCCCCCCCCE | 26.56 | 19664994 | |
| 133 | Phosphorylation | KGNAEGSSDEEGKLV CCCCCCCCCCCCCEE | 60.95 | 19664994 | |
| 146 | Succinylation | LVIDEPAKEKNEKGA EECCCCCHHHCCCCH | 78.80 | 23954790 | |
| 146 | Acetylation | LVIDEPAKEKNEKGA EECCCCCHHHCCCCH | 78.80 | 23236377 | |
| 146 | Ubiquitination | LVIDEPAKEKNEKGA EECCCCCHHHCCCCH | 78.80 | - | |
| 148 (in isoform 3) | Phosphorylation | - | 70.47 | 24719451 | |
| 149 (in isoform 3) | Phosphorylation | - | 58.25 | 24719451 | |
| 151 | Acetylation | PAKEKNEKGALKRRA CCHHHCCCCHHHHHH | 59.90 | 25953088 | |
| 165 | Phosphorylation | AGDLLEDSPKRPKEA HHHHHCCCCCCCCCC | 23.97 | 19664994 | |
| 167 | Ubiquitination | DLLEDSPKRPKEAEN HHHCCCCCCCCCCCC | 82.41 | - | |
| 167 | Acetylation | DLLEDSPKRPKEAEN HHHCCCCCCCCCCCC | 82.41 | 26051181 | |
| 180 | Ubiquitination | ENPEGEEKEAATLEV CCCCCCHHHCCEEEE | 48.64 | - | |
| 180 | Acetylation | ENPEGEEKEAATLEV CCCCCCHHHCCEEEE | 48.64 | 25953088 | |
| 181 (in isoform 3) | Phosphorylation | - | 46.98 | 24719451 | |
| 184 | Phosphorylation | GEEKEAATLEVERPL CCHHHCCEEEEECCC | 30.42 | 25159151 | |
| 193 | Sulfoxidation | EVERPLPMEVEKNST EEECCCCCCEECCCC | 13.68 | 21406390 | |
| 197 | Acetylation | PLPMEVEKNSTPSEP CCCCCEECCCCCCCC | 62.46 | 23236377 | |
| 197 | Ubiquitination | PLPMEVEKNSTPSEP CCCCCEECCCCCCCC | 62.46 | 21890473 | |
| 199 | Phosphorylation | PMEVEKNSTPSEPGS CCCEECCCCCCCCCC | 53.41 | 30266825 | |
| 200 (in isoform 3) | Phosphorylation | - | 39.98 | 27251275 | |
| 200 | Phosphorylation | MEVEKNSTPSEPGSG CCEECCCCCCCCCCC | 39.98 | 29255136 | |
| 202 | Phosphorylation | VEKNSTPSEPGSGRG EECCCCCCCCCCCCC | 57.41 | 29255136 | |
| 206 | Phosphorylation | STPSEPGSGRGPPQE CCCCCCCCCCCCCHH | 35.71 | 30266825 | |
| 208 | Methylation | PSEPGSGRGPPQEEE CCCCCCCCCCCHHHH | 57.02 | 115478363 | |
| 215 (in isoform 3) | Phosphorylation | - | 70.70 | 27251275 | |
| 216 (in isoform 3) | Phosphorylation | - | 70.71 | 27251275 | |
| 218 (in isoform 3) | Phosphorylation | - | 74.19 | 24719451 | |
| 222 (in isoform 3) | Phosphorylation | - | 51.38 | 27251275 | |
| 225 | Phosphorylation | EDEEEEATKEDAEAP HHHHHHHHHHHHHCC | 37.94 | 23927012 | |
| 226 | Ubiquitination | DEEEEATKEDAEAPG HHHHHHHHHHHHCCC | 61.72 | 2190698 | |
| 226 | Acetylation | DEEEEATKEDAEAPG HHHHHHHHHHHHCCC | 61.72 | 26051181 | |
| 235 | Methylation | DAEAPGIRDHESL-- HHHCCCCCCCCCC-- | 45.19 | 115478355 | |
| 239 | Phosphorylation | PGIRDHESL------ CCCCCCCCC------ | 35.64 | 25159151 | |
| 241 (in isoform 3) | Phosphorylation | - | 27251275 | ||
| 255 (in isoform 3) | Phosphorylation | - | 24719451 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of HDGF_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference |
|---|---|---|---|---|
| 165 | S | Phosphorylation |
| 15302935 |
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of HDGF_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Acetylation | |
| Reference | PubMed |
| "Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-44, AND MASS SPECTROMETRY. | |
| Phosphorylation | |
| Reference | PubMed |
| "Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-132; SER-133 ANDSER-165, AND MASS SPECTROMETRY. | |
| "Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-165, AND MASSSPECTROMETRY. | |
| "Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-132; SER-133 ANDSER-165, AND MASS SPECTROMETRY. | |
| "Large-scale phosphoproteome analysis of human liver tissue byenrichment and fractionation of phosphopeptides with strong anionexchange chromatography."; Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D.,Zou H., Gu J.; Proteomics 8:1346-1361(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-132; SER-133 ANDSER-165, AND MASS SPECTROMETRY. | |
| "A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-132; SER-133; SER-165;THR-200; SER-206 AND SER-239, AND MASS SPECTROMETRY. | |
| "Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-165, AND MASSSPECTROMETRY. | |
| "Phosphorylation analysis of primary human T lymphocytes usingsequential IMAC and titanium oxide enrichment."; Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J.; J. Proteome Res. 7:5167-5176(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-165, AND MASSSPECTROMETRY. | |
| "Phosphoproteome of resting human platelets."; Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.; J. Proteome Res. 7:526-534(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-132 AND SER-133, ANDMASS SPECTROMETRY. | |
| "Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column."; Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.; Anal. Sci. 24:161-166(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-132; SER-133 ANDSER-165, AND MASS SPECTROMETRY. | |
| "Toward a global characterization of the phosphoproteome in prostatecancer cells: identification of phosphoproteins in the LNCaP cellline."; Giorgianni F., Zhao Y., Desiderio D.M., Beranova-Giorgianni S.; Electrophoresis 28:2027-2034(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-132; SER-133 ANDSER-165, AND MASS SPECTROMETRY. | |
| "Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry."; Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.; Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-107; SER-132; SER-133AND SER-165, AND MASS SPECTROMETRY. | |
| "A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-132; SER-133; SER-165AND THR-200, AND MASS SPECTROMETRY. | |
| "Phosphoproteomic analysis of the human pituitary."; Beranova-Giorgianni S., Zhao Y., Desiderio D.M., Giorgianni F.; Pituitary 9:109-120(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-132 AND SER-133, ANDMASS SPECTROMETRY. | |
| "Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-132; SER-133 ANDSER-165, AND MASS SPECTROMETRY. | |
| "Global phosphoproteome of HT-29 human colon adenocarcinoma cells."; Kim J.-E., Tannenbaum S.R., White F.M.; J. Proteome Res. 4:1339-1346(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-165, AND MASSSPECTROMETRY. | |
| "Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-132; SER-133; SER-165;THR-200 AND SER-202, AND MASS SPECTROMETRY. | |
| Sumoylation | |
| Reference | PubMed |
| "SUMOylation of the hepatoma-derived growth factor negativelyinfluences its binding to chromatin."; Thakar K., Niedenthal R., Okaz E., Franken S., Jakobs A., Gupta S.,Kelm S., Dietz F.; FEBS J. 275:1411-1426(2008). Cited for: SUMOYLATION AT LYS-80. | |
