dbPTM

DDX50_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DDX50_HUMAN
UniProt AC	Q9BQ39
Protein Name	ATP-dependent RNA helicase DDX50
Gene Name	DDX50
Organism	Homo sapiens (Human).
Sequence Length	737
Subcellular Localization	Nucleus, nucleolus .
Protein Description
Protein Sequence	MPGKLLWGDIMELEAPLEESESQKKERQKSDRRKSRHHYDSDEKSETRENGVTDDLDAPKAKKSKMKEKLNGDTEEGFNRLSDEFSKSHKSRRKDLPNGDIDEYEKKSKRVSSLDTSTHKSSDNKLEETLTREQKEGAFSNFPISEETIKLLKGRGVTYLFPIQVKTFGPVYEGKDLIAQARTGTGKTFSFAIPLIERLQRNQETIKKSRSPKVLVLAPTRELANQVAKDFKDITRKLSVACFYGGTSYQSQINHIRNGIDILVGTPGRIKDHLQSGRLDLSKLRHVVLDEVDQMLDLGFAEQVEDIIHESYKTDSEDNPQTLLFSATCPQWVYKVAKKYMKSRYEQVDLVGKMTQKAATTVEHLAIQCHWSQRPAVIGDVLQVYSGSEGRAIIFCETKKNVTEMAMNPHIKQNAQCLHGDIAQSQREITLKGFREGSFKVLVATNVAARGLDIPEVDLVIQSSPPQDVESYIHRSGRTGRAGRTGICICFYQPRERGQLRYVEQKAGITFKRVGVPSTMDLVKSKSMDAIRSLASVSYAAVDFFRPSAQRLIEEKGAVDALAAALAHISGASSFEPRSLITSDKGFVTMTLESLEEIQDVSCAWKELNRKLSSNAVSQITRMCLLKGNMGVCFDVPTTESERLQAEWHDSDWILSVPAKLPEIEEYYDGNTSSNSRQRSGWSSGRSGRSGRSGGRSGGRSGRQSRQGSRSGSRQDGRRRSGNRNRSRSGGHKRSFD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	Phosphorylation	LEAPLEESESQKKER EECCCCCCHHHHHHH	32.92	27690223
22	Phosphorylation	APLEESESQKKERQK CCCCCCHHHHHHHHH	57.49	25627689
35	Phosphorylation	QKSDRRKSRHHYDSD HHHHHHHHHHCCCCC	34.73	21857030
39	Phosphorylation	RRKSRHHYDSDEKSE HHHHHHCCCCCCCCC	15.83	23927012
41	Phosphorylation	KSRHHYDSDEKSETR HHHHCCCCCCCCCCH	40.27	23401153
42	Ubiquitination	SRHHYDSDEKSETRE HHHCCCCCCCCCCHH	65.53	24816145
45	Phosphorylation	HYDSDEKSETRENGV CCCCCCCCCCHHCCC	42.00	28355574
47	Phosphorylation	DSDEKSETRENGVTD CCCCCCCCHHCCCCC	50.83	25159151
53	Phosphorylation	ETRENGVTDDLDAPK CCHHCCCCCCCCCHH	25.79	23927012
74	Phosphorylation	KEKLNGDTEEGFNRL HHHHCCCCHHHHHHH	37.02	22617229
82	Phosphorylation	EEGFNRLSDEFSKSH HHHHHHHHHHHHHHH	31.68	30266825
86	Phosphorylation	NRLSDEFSKSHKSRR HHHHHHHHHHHHHHC	31.07	30266825
87	Ubiquitination	RLSDEFSKSHKSRRK HHHHHHHHHHHHHCC	63.00	29967540
87	Acetylation	RLSDEFSKSHKSRRK HHHHHHHHHHHHHCC	63.00	25953088
94	Acetylation	KSHKSRRKDLPNGDI HHHHHHCCCCCCCCH	63.61	7822435
104	Phosphorylation	PNGDIDEYEKKSKRV CCCCHHHHHHHHHCH	29.33	-
106	Acetylation	GDIDEYEKKSKRVSS CCHHHHHHHHHCHHC	62.54	26051181
107	Ubiquitination	DIDEYEKKSKRVSSL CHHHHHHHHHCHHCC	49.63	24816145
112	Phosphorylation	EKKSKRVSSLDTSTH HHHHHCHHCCCCCCC	29.26	25159151
113	Phosphorylation	KKSKRVSSLDTSTHK HHHHCHHCCCCCCCC	27.66	25159151
116	Phosphorylation	KRVSSLDTSTHKSSD HCHHCCCCCCCCCCC	40.60	24732914
117	Phosphorylation	RVSSLDTSTHKSSDN CHHCCCCCCCCCCCC	28.34	24732914
118	Phosphorylation	VSSLDTSTHKSSDNK HHCCCCCCCCCCCCH	35.10	24732914
120	Ubiquitination	SLDTSTHKSSDNKLE CCCCCCCCCCCCHHH	52.31	29967540
121	Phosphorylation	LDTSTHKSSDNKLEE CCCCCCCCCCCHHHH	35.01	-
122	Phosphorylation	DTSTHKSSDNKLEET CCCCCCCCCCHHHHH	50.43	-
125	Acetylation	THKSSDNKLEETLTR CCCCCCCHHHHHHHH	63.37	26051181
125	Ubiquitination	THKSSDNKLEETLTR CCCCCCCHHHHHHHH	63.37	29967540
125	Sumoylation	THKSSDNKLEETLTR CCCCCCCHHHHHHHH	63.37	28112733
135	Ubiquitination	ETLTREQKEGAFSNF HHHHHHHHCCCCCCC	54.05	29967540
135	Sumoylation	ETLTREQKEGAFSNF HHHHHHHHCCCCCCC	54.05	-
138	Ubiquitination	TREQKEGAFSNFPIS HHHHHCCCCCCCCCC	13.04	21890473
140	Phosphorylation	EQKEGAFSNFPISEE HHHCCCCCCCCCCHH	36.71	21082442
143	Ubiquitination	EGAFSNFPISEETIK CCCCCCCCCCHHHHH	33.18	24816145
150	Acetylation	PISEETIKLLKGRGV CCCHHHHHHHCCCCC	56.01	25953088
150	Ubiquitination	PISEETIKLLKGRGV CCCHHHHHHHCCCCC	56.01	32015554
150	Sumoylation	PISEETIKLLKGRGV CCCHHHHHHHCCCCC	56.01	-
167	Ubiquitination	LFPIQVKTFGPVYEG EEEEEEEEECCEECC	34.66	24816145
175	Ubiquitination	FGPVYEGKDLIAQAR ECCEECCCEEEEECC	37.10	29967540
187	Ubiquitination	QARTGTGKTFSFAIP ECCCCCCCHHHHHHH	46.35	-
187	Acetylation	QARTGTGKTFSFAIP ECCCCCCCHHHHHHH	46.35	26051181
188	Phosphorylation	ARTGTGKTFSFAIPL CCCCCCCHHHHHHHH	26.34	20068231
190	Phosphorylation	TGTGKTFSFAIPLIE CCCCCHHHHHHHHHH	20.99	20068231
208	Ubiquitination	RNQETIKKSRSPKVL HCHHHHHHCCCCCEE	47.45	24816145
211	Phosphorylation	ETIKKSRSPKVLVLA HHHHHCCCCCEEEEC	35.84	-
229	Ubiquitination	ELANQVAKDFKDITR HHHHHHHHHHHHHHH	65.91	29967540
232	Acetylation	NQVAKDFKDITRKLS HHHHHHHHHHHHHHH	59.35	25953088
232	Ubiquitination	NQVAKDFKDITRKLS HHHHHHHHHHHHHHH	59.35	24816145
244	Phosphorylation	KLSVACFYGGTSYQS HHHHHHHCCCCCHHH	17.96	30576142
247	Phosphorylation	VACFYGGTSYQSQIN HHHHCCCCCHHHHHH	21.65	-
251	Phosphorylation	YGGTSYQSQINHIRN CCCCCHHHHHHHHHC	25.46	-
266	Phosphorylation	GIDILVGTPGRIKDH CCCEEECCCCHHHHH	18.32	23401153
283	Ubiquitination	SGRLDLSKLRHVVLD CCCCCHHHHHHHHHH	57.76	-
322	Phosphorylation	DSEDNPQTLLFSATC CCCCCCCEEEEEECC	27.04	-
345	Phosphorylation	KKYMKSRYEQVDLVG HHHHHHHHHHHHHHH	20.15	-
353	Ubiquitination	EQVDLVGKMTQKAAT HHHHHHHHHHHHHHH	31.15	29967540
367	Ubiquitination	TTVEHLAIQCHWSQR HHHHHHHHHCCHHCC	5.89	21890473
412	Ubiquitination	MAMNPHIKQNAQCLH HHCCHHHHHHHHHHC	34.17	29967540
432	Acetylation	SQREITLKGFREGSF HCCEEEEECCCCCCE	47.56	25953088
432	Ubiquitination	SQREITLKGFREGSF HCCEEEEECCCCCCE	47.56	21890473
432	Methylation	SQREITLKGFREGSF HCCEEEEECCCCCCE	47.56	-
438	Phosphorylation	LKGFREGSFKVLVAT EECCCCCCEEEEEEE	19.69	23403867
445	Phosphorylation	SFKVLVATNVAARGL CEEEEEEECHHHCCC	23.81	24114839
461	Ubiquitination	IPEVDLVIQSSPPQD CCCCCEEEECCCCCC	4.23	24816145
463	Phosphorylation	EVDLVIQSSPPQDVE CCCEEEECCCCCCHH	33.42	28122231
464	Phosphorylation	VDLVIQSSPPQDVES CCEEEECCCCCCHHH	24.99	28122231
471	Phosphorylation	SPPQDVESYIHRSGR CCCCCHHHHHHHCCC	29.27	28122231
472	Phosphorylation	PPQDVESYIHRSGRT CCCCHHHHHHHCCCC	6.29	28122231
506	Acetylation	QLRYVEQKAGITFKR CCEEEHHHCCCCEEE	34.77	25953088
506	Ubiquitination	QLRYVEQKAGITFKR CCEEEHHHCCCCEEE	34.77	-
512	Methylation	QKAGITFKRVGVPST HHCCCCEEECCCCCH	37.21	-
512	Ubiquitination	QKAGITFKRVGVPST HHCCCCEEECCCCCH	37.21	29967540
518	Phosphorylation	FKRVGVPSTMDLVKS EEECCCCCHHHHHHC	33.68	20068231
519	Phosphorylation	KRVGVPSTMDLVKSK EECCCCCHHHHHHCC	14.50	20068231
524	Ubiquitination	PSTMDLVKSKSMDAI CCHHHHHHCCCHHHH	60.51	29967540
526	Ubiquitination	TMDLVKSKSMDAIRS HHHHHHCCCHHHHHH	44.04	24816145
606	Acetylation	QDVSCAWKELNRKLS HHHHHHHHHHHHHHC	33.52	11921489
611	Ubiquitination	AWKELNRKLSSNAVS HHHHHHHHHCHHHHH	52.20	29967540
613	Phosphorylation	KELNRKLSSNAVSQI HHHHHHHCHHHHHHH	25.28	23927012
614	Phosphorylation	ELNRKLSSNAVSQIT HHHHHHCHHHHHHHH	38.96	23927012
618	Phosphorylation	KLSSNAVSQITRMCL HHCHHHHHHHHHHHH	17.29	30622161
621	Phosphorylation	SNAVSQITRMCLLKG HHHHHHHHHHHHHCC	12.52	30622161
630	Sulfoxidation	MCLLKGNMGVCFDVP HHHHCCCCEEEEECC	6.08	21406390
668	Phosphorylation	LPEIEEYYDGNTSSN CCCHHHHCCCCCCCC	22.21	23186163
672	Phosphorylation	EEYYDGNTSSNSRQR HHHCCCCCCCCCCCC	38.78	25159151
673	Phosphorylation	EYYDGNTSSNSRQRS HHCCCCCCCCCCCCC	31.36	25159151
674	Phosphorylation	YYDGNTSSNSRQRSG HCCCCCCCCCCCCCC	36.46	23186163
676	Phosphorylation	DGNTSSNSRQRSGWS CCCCCCCCCCCCCCC	31.57	25159151
680	Phosphorylation	SSNSRQRSGWSSGRS CCCCCCCCCCCCCCC	35.95	23186163
683	Phosphorylation	SRQRSGWSSGRSGRS CCCCCCCCCCCCCCC	26.83	23401153
684	Phosphorylation	RQRSGWSSGRSGRSG CCCCCCCCCCCCCCC	31.55	30576142
687	Phosphorylation	SGWSSGRSGRSGRSG CCCCCCCCCCCCCCC	41.92	26657352
713	Phosphorylation	RQGSRSGSRQDGRRR CCCCCCCCCCCCCCC	28.19	-
735	Phosphorylation	RSGGHKRSFD----- CCCCCCCCCC-----	38.27	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DDX50_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DDX50_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DDX50_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RASK_HUMAN	KRAS	physical	21988832
PRKRA_HUMAN	PRKRA	physical	24778252
TRBP2_HUMAN	TARBP2	physical	24778252
DDX21_HUMAN	DDX21	physical	26344197

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DDX50_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-82, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-45, AND MASSSPECTROMETRY.	17081983 [Abstract]