CG050_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CG050_HUMAN
• UniProt AC: Q9BRJ6
• Protein Name: Uncharacterized protein C7orf50
• Gene Name: C7orf50
• Organism: Homo sapiens (Human).
• Sequence Length: 194
• Protein Sequence: MAKQKRKVPEVTEKKNKKLKKASAEGPLLGPEAAPSGEGAGSKGEAVLRPGLDAEPELSPEEQRVLERKLKKERKKEERQRLREAGLVAQHPPARRSGAELALDYLCRWAQKHKNWRFQKTRQTWLLLHMYDSDKVPDEHFSTLLAYLEGLQGRARELTVQKAEALMRELDEEGSDPPLPGRAQRIRQVLQLLS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Acetylation	-----MAKQKRKVPE -----CCCCCCCCCH	55.86	7304113
14	2-Hydroxyisobutyrylation	KVPEVTEKKNKKLKK CCCHHHHHHCHHHHH	52.89	-
14	Acetylation	KVPEVTEKKNKKLKK CCCHHHHHHCHHHHH	52.89	25953088
23	Phosphorylation	NKKLKKASAEGPLLG CHHHHHHCCCCCCCC	35.41	30266825
36	Phosphorylation	LGPEAAPSGEGAGSK CCCCCCCCCCCCCCC	44.76	21815630
42	Phosphorylation	PSGEGAGSKGEAVLR CCCCCCCCCCCEEEC	36.63	25850435
43	Acetylation	SGEGAGSKGEAVLRP CCCCCCCCCCEEECC	60.91	26051181
59	Phosphorylation	LDAEPELSPEEQRVL CCCCCCCCHHHHHHH	28.71	29255136
97	Phosphorylation	QHPPARRSGAELALD CCCCCHHCCHHHHHH	36.48	25159151
105	Phosphorylation	GAELALDYLCRWAQK CHHHHHHHHHHHHHH	14.46	22817900
107	Glutathionylation	ELALDYLCRWAQKHK HHHHHHHHHHHHHHC	2.51	22555962
162	Acetylation	ARELTVQKAEALMRE HHHHHHHHHHHHHHH	43.81	25953088
175	Phosphorylation	RELDEEGSDPPLPGR HHHHHCCCCCCCCHH	50.66	19664994

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	SMURF1	Q9HCE7	PMID:20804422

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CG050_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CG050_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-23; SER-59; SER-97 ANDSER-175, AND MASS SPECTROMETRY.
PubMed: 18669648

"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry.";
Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.;
Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-59, AND MASSSPECTROMETRY.
PubMed: 17287340

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-175, AND MASSSPECTROMETRY.
PubMed: 17081983