ZDBF2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZDBF2_HUMAN
• UniProt AC: Q9HCK1
• Protein Name: DBF4-type zinc finger-containing protein 2
• Gene Name: ZDBF2
• Organism: Homo sapiens (Human).
• Sequence Length: 2354
• Protein Sequence: MQKRQGYCSYCRVQYNNLEQHLFSAQHRSLTRQSRRQICTSSLMERFLQDVLQHHPYHCQESSSTQDETHVNTGSSSEVVHLDDAFSEEEEEDEDKVEDEDATEERPSEVSEPIEELHSRPHKSQEGTQEVSVRPSVIQKLEKGQQQPLEFVHKIGASVRKCNLVDIGQATNNRSNLVRPPVICNAPASCLPESSNDRPVTANTTSLPPAAHLDSVSKCDPNKVEKYLEQPDGASRNPVPSSHVETTSFSYQKHKESNRKSLRMNSDKLVLWKDVKSQGKTLSAGLKFHERMGTKGSLRVKSPSKLAVNPNKTDMPSNKGIFEDTIAKNHEEFFSNMDCTQEEKHLVFNKTAFWEQKCSVSSEMKFDCISLQSASDQPQETAQDLSLWKEEQIDQEDNYESRGSEMSFDCSSSFHSLTDQSKVSAKEVNLSKEVRTDVQYKNNKSYVSKISSDCDDILHLVTNQSQMIVKEISLQNARHISLVDQSYESSSSETNFDCDASPQSTSDYPQQSVTEVNLPKEVHIGLVDKNYGSSSSEVSADSVFPLQSVVDRPPVAVTETKLRKKAHTSLVDNYGSSCSETSFDCDVSLESVVDHPQLTVKGRNLKGRQVHLKHKKRKPSSAKAHLDCDVSLGTVADESQRAVEKINLLKEKNADLMDMNCESHGPEMGFQADAQLADQSQVAEIERQKVDVDLENKSVQSSRSSLSSDSPASLYHSAHDEPQEALDEVNLKELNIDMEVRSYDCSSSELTFDSDPPLLSVTEQSHLDAEGKERHIDLEDESCESDSSEITFDSDIPLYSVIDQPEVAVYEEETVDLESKSNESCVSEITFDSDIPLHSGNDHPEVAVKEVIQKEEYIHLERKNDEPSGSEISSDSHAPLHSVTNSPEVAVKKLNPQKEEQVHLENKENEPIDSEVSLDYNIIFHSVTGRSEDPIKEISLHTKEHMYLENKSVFETSLDSDVPLQAATHKPEVIVKETWLQREKHAEFQGRSTEFSGSKTSLDSGVPHYSVTEPQVAVNKINRKKQYVLENKNDKCSGSEIILDSNVPPQSMTDQPQLAFLKEKHVNLKDKNSKSGDSKITFDSEQLQEAVKKIDQWKEEVIGLKNKINEPSTYKLIHHPDVSVQSVADQPKVAIKHVNLGNENHMYLEVKNSQYSCSEMNLDSGFLGQSIVNRPQITILEQEHIELEGKHNQCCGSEVSFDSDDPLQSVADRLRETVKEISLWKDEEVDTEDRRNEAKGFEIMYDSDVLQPVAGQPEEVVKEVSLWKEHVDLENKIVKPTDSRINFDSHEPLQSVTNKIPGANKEINLLREEHVCLDDKGYVPSDSEIIYVSNIPLQSVIKQPHILEEEHASLEDKSSNSYSPEESSDSNDSFQAAADELQKPVKEINLWKEDHIYLEDKSYKLGDFDVSYASHIPVQFVTDQSSVPVKEINLQKKDHNDLENKNCEVCGSEIKCHSCVHLQSEVDQPQVSYKEADLQKEEHVVMEEKTDQPSDSEMMYDSDVPFQIVVNQFPGSVKETHLPKVVLVDLVPGDSDYEVISDDIPLQLVTDPPQLTVKDISCINTECIDIEDKSCDFFGSEVRCNCKASTPSMTNQCKETFKIINRKKDYIILGEPSCQSCGSEMNFNVDASDQSMTYESQGPDEKMVKYIDSEDKSCGYNGSKGKFNLEDTSHRTTHRLQKAHKEASLRKDPRNAGLKGKSCQSSASAVDFGASSKSALHRRADKKKRSKLKHRDLEVSCEPDGFEMNFQCAPPLPSDTDQPQETVKKRHPCKKVSSDLKEKNHDSQSSSVLKVDSVRNLKKAKDVIEDNPDEPVLEALPHVPPSFVGKTWSQIMREDDIKINALVKEFREGRFHCYFDDDCETKKVSSKGKKKVTWADLQGKEDTAPTQAVSESDDIVCGISDIDDLSVALDKPCHRHPPAERPPKQKGRVASQCQTAKISHSTQTSCKNYPVMKRKIIRQEEDPPKSKCSRLQDDRKTKKKVKIGTVEFPASCTKVLKPMQPKALVCVLSSLNIKLKEGEGLPFPKMRHHSWDNDIRFICKYKRNIFDYYEPLIKQIVISPPLSVIVPEFERRNWVKIHFNRSNQNSSAGDNDADGQGSASAPLMAVPARYGFNSHQGTSDSSLFLEESKVLHARELPKKRNFQLTFLNHDVVKISPKSVRNKLLESQSKKKIHGKRVTTSSNKLGFPKKVYKPIILQQKPRKASEKQSIWIRTKPSDIIRKYISKYSVFLRHRYQSRSAFLGRYLKKKKSVVSRLKKAKRTAKVLLNSSVPPAGAEELSSAMANPPPKRPVRASCRVARRRKKTDESYHGRQKGPSTPVRAYDLRSSSCLQQRERMMTRLANKLRGNEVK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
40	O-linked_Glycosylation	QSRRQICTSSLMERF HHHHHHHHHHHHHHH	23.99	30379171
41	O-linked_Glycosylation	SRRQICTSSLMERFL HHHHHHHHHHHHHHH	19.64	30379171
108	Phosphorylation	DATEERPSEVSEPIE CCCCCCCCCCCCCHH	57.77	21082442
111	Phosphorylation	EERPSEVSEPIEELH CCCCCCCCCCHHHHH	33.34	21082442
124	Phosphorylation	LHSRPHKSQEGTQEV HHCCCCCCCCCCEEC	30.35	25159151
158	Phosphorylation	FVHKIGASVRKCNLV HHHHHCCCEEECCEE	19.76	24905233
241	Phosphorylation	ASRNPVPSSHVETTS CCCCCCCCCCCEECC	33.05	-
242	Phosphorylation	SRNPVPSSHVETTSF CCCCCCCCCCEECCC	26.02	28555341
246	Phosphorylation	VPSSHVETTSFSYQK CCCCCCEECCCCHHH	27.01	28555341
250	Phosphorylation	HVETTSFSYQKHKES CCEECCCCHHHHHHH	26.82	28555341
266	O-linked_Glycosylation	RKSLRMNSDKLVLWK CHHHCCCCCCEEEEE	27.12	30379171
287	Methylation	KTLSAGLKFHERMGT CEEHHHCHHHHHCCC	43.70	115978345
302	Phosphorylation	KGSLRVKSPSKLAVN CCCEEECCHHHEECC	31.39	29214152
304	Phosphorylation	SLRVKSPSKLAVNPN CEEECCHHHEECCCC	47.60	28060719
370	Phosphorylation	EMKFDCISLQSASDQ CCEEEEEECCCCCCC	27.04	20873877
373	Phosphorylation	FDCISLQSASDQPQE EEEEECCCCCCCCCH	34.73	20873877
375	Phosphorylation	CISLQSASDQPQETA EEECCCCCCCCCHHH	41.86	20873877
381	Phosphorylation	ASDQPQETAQDLSLW CCCCCCHHHHHHHHH	25.11	20873877
401	Phosphorylation	DQEDNYESRGSEMSF CCCCCCCCCCCCCCC	31.42	26471730
413	Phosphorylation	MSFDCSSSFHSLTDQ CCCCCCHHCCCCCCC	15.64	-
431	Phosphorylation	SAKEVNLSKEVRTDV CHHHCCCCHHHHHHE	22.90	27134283
446	Phosphorylation	QYKNNKSYVSKISSD EECCCHHHHHHHHCC	15.45	18669648
462	Phosphorylation	DDILHLVTNQSQMIV HHHHHHHCCHHHHHH	33.62	18669648
465	Phosphorylation	LHLVTNQSQMIVKEI HHHHCCHHHHHHHHH	24.64	18669648
473	Phosphorylation	QMIVKEISLQNARHI HHHHHHHHHCCCCEE	25.62	28555341
531	Phosphorylation	IGLVDKNYGSSSSEV EEEECCCCCCCCCCC	24.91	22817900
533	Phosphorylation	LVDKNYGSSSSEVSA EECCCCCCCCCCCCC	19.38	22817900
534	Phosphorylation	VDKNYGSSSSEVSAD ECCCCCCCCCCCCCC	33.26	22817900
535	Phosphorylation	DKNYGSSSSEVSADS CCCCCCCCCCCCCCC	32.01	22817900
536	Phosphorylation	KNYGSSSSEVSADSV CCCCCCCCCCCCCCC	43.92	22817900
539	Phosphorylation	GSSSSEVSADSVFPL CCCCCCCCCCCCCCC	23.47	22817900
548	Phosphorylation	DSVFPLQSVVDRPPV CCCCCCCHHCCCCCE	31.61	-
560	Phosphorylation	PPVAVTETKLRKKAH CCEEEEEHHHHHHCC	26.47	-
620	Phosphorylation	KHKKRKPSSAKAHLD CCCCCCCCCCCHHCC	46.06	-
631	Phosphorylation	AHLDCDVSLGTVADE HHCCCCCCCCCCCCH	14.08	25159151
698	Phosphorylation	DVDLENKSVQSSRSS CCCCCCCCCHHHHHH	36.65	23312004
701	Phosphorylation	LENKSVQSSRSSLSS CCCCCCHHHHHHCCC	26.09	23312004
702	Phosphorylation	ENKSVQSSRSSLSSD CCCCCHHHHHHCCCC	21.06	23312004
821	Phosphorylation	TVDLESKSNESCVSE EECCCCCCCCCCEEE	55.92	26471730
824	Phosphorylation	LESKSNESCVSEITF CCCCCCCCCEEEEEE	24.86	26471730
827	Phosphorylation	KSNESCVSEITFDSD CCCCCCEEEEEECCC	27.84	26471730
868	Phosphorylation	ERKNDEPSGSEISSD EECCCCCCCCCCCCC	53.56	27732954
870	Phosphorylation	KNDEPSGSEISSDSH CCCCCCCCCCCCCCC	35.77	27732954
873	Phosphorylation	EPSGSEISSDSHAPL CCCCCCCCCCCCCCC	24.84	27732954
874	Phosphorylation	PSGSEISSDSHAPLH CCCCCCCCCCCCCCC	49.12	27732954
876	Phosphorylation	GSEISSDSHAPLHSV CCCCCCCCCCCCCCC	24.40	27732954
882	Phosphorylation	DSHAPLHSVTNSPEV CCCCCCCCCCCCHHH	38.02	25159151
884	Phosphorylation	HAPLHSVTNSPEVAV CCCCCCCCCCHHHHH	32.75	25159151
886	Phosphorylation	PLHSVTNSPEVAVKK CCCCCCCCHHHHHHH	17.05	25159151
892	Acetylation	NSPEVAVKKLNPQKE CCHHHHHHHCCCCHH	41.63	26051181
898	Acetylation	VKKLNPQKEEQVHLE HHHCCCCHHHHEECC	65.56	20167786
952	Phosphorylation	HMYLENKSVFETSLD CEEECCCCCEEECCC	43.55	20873877
956	Phosphorylation	ENKSVFETSLDSDVP CCCCCEEECCCCCCC	24.11	25159151
957	Phosphorylation	NKSVFETSLDSDVPL CCCCEEECCCCCCCC	24.00	20873877
960	Phosphorylation	VFETSLDSDVPLQAA CEEECCCCCCCCCHH	45.89	20873877
968	Phosphorylation	DVPLQAATHKPEVIV CCCCCHHCCCCEEEE	33.19	20873877
996	Phosphorylation	QGRSTEFSGSKTSLD CCCCCEECCCCCCCC	35.61	-
1027	Phosphorylation	KINRKKQYVLENKND HHHHHHEEEECCCCC	18.84	21406692
1079	Acetylation	NSKSGDSKITFDSEQ CCCCCCCCCCCCHHH	50.97	20167786
1126	Phosphorylation	HPDVSVQSVADQPKV CCCCCHHHCCCCCCE	19.67	28555341
1197	Phosphorylation	KHNQCCGSEVSFDSD CCCCCCCCCCCCCCC	22.40	22617229
1200	Phosphorylation	QCCGSEVSFDSDDPL CCCCCCCCCCCCCHH	21.20	22617229
1203	Phosphorylation	GSEVSFDSDDPLQSV CCCCCCCCCCHHHHH	41.73	22617229
1209	Phosphorylation	DSDDPLQSVADRLRE CCCCHHHHHHHHHHH	27.27	27732954
1283	Phosphorylation	KIVKPTDSRINFDSH CEECCCCCCCCCCCC	37.22	28555341
1322	Phosphorylation	VCLDDKGYVPSDSEI EECCCCCCCCCCCEE	18.22	27732954
1325	Phosphorylation	DDKGYVPSDSEIIYV CCCCCCCCCCEEEEE	43.66	27732954
1327	Phosphorylation	KGYVPSDSEIIYVSN CCCCCCCCEEEEEEC	34.72	27732954
1331	Phosphorylation	PSDSEIIYVSNIPLQ CCCCEEEEEECCCHH	11.95	27732954
1333	Phosphorylation	DSEIIYVSNIPLQSV CCEEEEEECCCHHHH	16.45	27732954
1353	Phosphorylation	ILEEEHASLEDKSSN CHHHHHCCCCCCCCC	33.91	24850871
1430	Acetylation	DQSSVPVKEINLQKK CCCCCCCEEEECCCC	46.97	26051181
1574	Phosphorylation	CIDIEDKSCDFFGSE EEECCCCCCCCCCCE	31.10	25850435
1701	Acetylation	RNAGLKGKSCQSSAS CCCCCCCCCCCCCCC	46.61	30593497
1706	Phosphorylation	KGKSCQSSASAVDFG CCCCCCCCCCHHCCC	10.60	-
1715	Phosphorylation	SAVDFGASSKSALHR CHHCCCCCCHHHHHH	38.38	24043423
1716	Phosphorylation	AVDFGASSKSALHRR HHCCCCCCHHHHHHH	30.05	24043423
1718	Phosphorylation	DFGASSKSALHRRAD CCCCCCHHHHHHHHC	37.70	24043423
1778	Phosphorylation	HPCKKVSSDLKEKNH CCCCCCCCCHHHHCC	50.37	-
1842	Ubiquitination	IMREDDIKINALVKE HHCCCCCCHHHHHHH	36.58	-
1870	O-linked_Glycosylation	CETKKVSSKGKKKVT CCCEEECCCCCCEEE	48.71	30379171
1953	Phosphorylation	TQTSCKNYPVMKRKI CCCCCCCCCHHHHHH	5.23	22461510
1957	Trimethylation	CKNYPVMKRKIIRQE CCCCCHHHHHHHHCC	51.26	-
1957	Methylation	CKNYPVMKRKIIRQE CCCCCHHHHHHHHCC	51.26	23644510
1995	Phosphorylation	GTVEFPASCTKVLKP EEEECCCHHCCCCCC	23.66	-
1997	Phosphorylation	VEFPASCTKVLKPMQ EECCCHHCCCCCCCC	22.99	-
2013	Phosphorylation	KALVCVLSSLNIKLK CCEEEHHHHCCCEEC	16.63	-
2014	Phosphorylation	ALVCVLSSLNIKLKE CEEEHHHHCCCEECC	22.67	-
2034	Phosphorylation	FPKMRHHSWDNDIRF CCCCCCCCCCCCHHH	29.96	29449344
2133	Ubiquitination	SLFLEESKVLHAREL CCCHHHHHHEECCCC	52.69	21890473
2166	Acetylation	SPKSVRNKLLESQSK CHHHHHHHHHHHHHC	43.83	7663129
2170	Phosphorylation	VRNKLLESQSKKKIH HHHHHHHHHHCCCCC	39.46	29978859
2172	Phosphorylation	NKLLESQSKKKIHGK HHHHHHHHCCCCCCE	56.58	29978859
2173	Acetylation	KLLESQSKKKIHGKR HHHHHHHCCCCCCEE	50.91	7663137
2182	Phosphorylation	KIHGKRVTTSSNKLG CCCCEEECCCCCCCC	25.62	29978859
2183	Phosphorylation	IHGKRVTTSSNKLGF CCCEEECCCCCCCCC	27.57	29978859
2184	Phosphorylation	HGKRVTTSSNKLGFP CCEEECCCCCCCCCC	23.65	29759185
2185	Phosphorylation	GKRVTTSSNKLGFPK CEEECCCCCCCCCCC	35.57	29759185
2195	Phosphorylation	LGFPKKVYKPIILQQ CCCCCHHCCCEECCC	21.67	-
2225	Ubiquitination	KPSDIIRKYISKYSV CHHHHHHHHHHHHHH	36.21	-
2226	Phosphorylation	PSDIIRKYISKYSVF HHHHHHHHHHHHHHH	10.69	21394647
2228	Phosphorylation	DIIRKYISKYSVFLR HHHHHHHHHHHHHHH	23.58	24719451
2230	Phosphorylation	IRKYISKYSVFLRHR HHHHHHHHHHHHHHH	11.86	21394647
2238	Phosphorylation	SVFLRHRYQSRSAFL HHHHHHHHHCHHHHH	12.52	24719451
2240	Phosphorylation	FLRHRYQSRSAFLGR HHHHHHHCHHHHHHH	21.19	24719451
2272	Phosphorylation	TAKVLLNSSVPPAGA HHHHHHCCCCCCCCH	32.45	28348404
2273	Phosphorylation	AKVLLNSSVPPAGAE HHHHHCCCCCCCCHH	37.25	28348404
2283	Phosphorylation	PAGAEELSSAMANPP CCCHHHHHHHHCCCC	21.23	28348404
2284	Phosphorylation	AGAEELSSAMANPPP CCHHHHHHHHCCCCC	34.39	28348404
2311	Phosphorylation	RRKKTDESYHGRQKG HHCCCCCCCCCCCCC	25.82	24719451
2312	Phosphorylation	RKKTDESYHGRQKGP HCCCCCCCCCCCCCC	13.27	24719451
2320	Phosphorylation	HGRQKGPSTPVRAYD CCCCCCCCCCCCHHH	54.75	27251275
2321	Phosphorylation	GRQKGPSTPVRAYDL CCCCCCCCCCCHHHC	29.01	27251275
2330	Phosphorylation	VRAYDLRSSSCLQQR CCHHHCCCCHHHHHH	33.62	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZDBF2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZDBF2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZDBF2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ZDBF2_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-531; SER-533; SER-534;SER-535; SER-536 AND SER-539, AND MASS SPECTROMETRY.
PubMed: 17081983