RAIN_HUMAN - dbPTM
RAIN_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RAIN_HUMAN
UniProt AC Q5U651
Protein Name Ras-interacting protein 1
Gene Name RASIP1
Organism Homo sapiens (Human).
Sequence Length 963
Subcellular Localization Cytoplasm, perinuclear region . Golgi apparatus, Golgi stack . Associated with perinuclear vesicles. Is recruited to Golgi stacks by activated HRAS.
Protein Description Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells (By similarity). May act as effector for Golgi-bound HRAS and other Ras-like proteins. May promote HRAS-mediated transformation. Negative regulator of amino acid starvation-induced autophagy..
Protein Sequence MLSGERKEGGSPRFGKLHLPVGLWINSPRKQLAKLGRRWPSAASVKSSSSDTGSRSSEPLPPPPPHVELRRVGAVKAAGGASGSRAKRISQLFRGSGTGTTGSSGAGGPGTPGGAQRWASEKKLPELAAGVAPEPPLATRATAPPGVLKIFGAGLASGANYKSVLATARSTARELVAEALERYGLAGSPGGGPGESSCVDAFALCDALGRPAAAGVGSGEWRAEHLRVLGDSERPLLVQELWRARPGWARRFELRGREEARRLEQEAFGAADSEGTGAPSWRPQKNRSRAASGGAALASPGPGTGSGAPAGSGGKERSENLSLRRSVSELSLQGRRRRQQERRQQALSMAPGAADAQIGTADPGDFDQLTQCLIQAPSNRPYFLLLQGYQDAQDFVVYVMTREQHVFGRGGNSSGRGGSPAPYVDTFLNAPDILPRHCTVRAGPEHPAMVRPSRGAPVTHNGCLLLREAELHPGDLLGLGEHFLFMYKDPRTGGSGPARPPWLPARPGATPPGPGWAFSCRLCGRGLQERGEALAAYLDGREPVLRFRPREEEALLGEIVRAAAAGSGDLPPLGPATLLALCVQHSARELELGHLPRLLGRLARLIKEAVWEKIKEIGDRQPENHPEGVPEVPLTPEAVSVELRPLMLWMANTTELLSFVQEKVLEMEKEADQEDPQLCNDLELCDEAMALLDEVIMCTFQQSVYYLTKTLYSTLPALLDSNPFTAGAELPGPGAELGAMPPGLRPTLGVFQAALELTSQCELHPDLVSQTFGYLFFFSNASLLNSLMERGQGRPFYQWSRAVQIRTNLDLVLDWLQGAGLGDIATEFFRKLSMAVNLLCVPRTSLLKASWSSLRTDHPTLTPAQLHHLLSHYQLGPGRGPPAAWDPPPAEREAVDTGDIFESFSSHPPLILPLGSSRLRLTGPVTDDALHRELRRLRRLLWDLEQQELPANYRHGPPVATSP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MLSGERKEGG
-----CCCCCCCCCC		36.9927499020
11PhosphorylationGERKEGGSPRFGKLH
CCCCCCCCCCCCCCC		24.6124719451
27PhosphorylationPVGLWINSPRKQLAK
CCEEEECCHHHHHHH		19.5630153514
41PhosphorylationKLGRRWPSAASVKSS
HHCCCCCCCCCCCCC		29.5223403867
44PhosphorylationRRWPSAASVKSSSSD
CCCCCCCCCCCCCCC		29.7823403867
47PhosphorylationPSAASVKSSSSDTGS
CCCCCCCCCCCCCCC		33.0423403867
48PhosphorylationSAASVKSSSSDTGSR
CCCCCCCCCCCCCCC		28.3023403867
49PhosphorylationAASVKSSSSDTGSRS
CCCCCCCCCCCCCCC		39.0523403867
50PhosphorylationASVKSSSSDTGSRSS
CCCCCCCCCCCCCCC		40.9323403867
52PhosphorylationVKSSSSDTGSRSSEP
CCCCCCCCCCCCCCC		38.7223403867
54PhosphorylationSSSSDTGSRSSEPLP
CCCCCCCCCCCCCCC		30.9523403867
90PhosphorylationGSRAKRISQLFRGSG
CHHHHHHHHHHCCCC		25.5123403867
94MethylationKRISQLFRGSGTGTT
HHHHHHHCCCCCCCC		47.13-
96PhosphorylationISQLFRGSGTGTTGS
HHHHHCCCCCCCCCC		29.0023403867
98PhosphorylationQLFRGSGTGTTGSSG
HHHCCCCCCCCCCCC		32.8123403867
100PhosphorylationFRGSGTGTTGSSGAG
HCCCCCCCCCCCCCC		28.0223403867
101PhosphorylationRGSGTGTTGSSGAGG
CCCCCCCCCCCCCCC		36.0927251275
103PhosphorylationSGTGTTGSSGAGGPG
CCCCCCCCCCCCCCC		24.4128857561
104PhosphorylationGTGTTGSSGAGGPGT
CCCCCCCCCCCCCCC		33.7223403867
111PhosphorylationSGAGGPGTPGGAQRW
CCCCCCCCCCHHHHH		23.1523403867
120PhosphorylationGGAQRWASEKKLPEL
CHHHHHHHHCCCHHH		42.8824719451
161PhosphorylationGLASGANYKSVLATA
CCCCCCCHHHHHHHH		12.24-
183PhosphorylationVAEALERYGLAGSPG
HHHHHHHHCCCCCCC		13.7124275569
188PhosphorylationERYGLAGSPGGGPGE
HHHCCCCCCCCCCCC		18.1126657352
196PhosphorylationPGGGPGESSCVDAFA
CCCCCCCCCHHHHHH		34.6525332170
280PhosphorylationSEGTGAPSWRPQKNR
CCCCCCCCCCCCCCC		34.8724719451
288PhosphorylationWRPQKNRSRAASGGA
CCCCCCCCCHHHCCC		35.3522210691
292PhosphorylationKNRSRAASGGAALAS
CCCCCHHHCCCCCCC		36.4526657352
299PhosphorylationSGGAALASPGPGTGS
HCCCCCCCCCCCCCC		31.1026657352
304PhosphorylationLASPGPGTGSGAPAG
CCCCCCCCCCCCCCC		31.1623403867
318PhosphorylationGSGGKERSENLSLRR
CCCCHHHCCCHHHHH		31.7426437602
322PhosphorylationKERSENLSLRRSVSE
HHHCCCHHHHHHHHH		31.2623403867
326PhosphorylationENLSLRRSVSELSLQ
CCHHHHHHHHHHHHH		24.4623403867
328PhosphorylationLSLRRSVSELSLQGR
HHHHHHHHHHHHHHH		33.7826846344
331PhosphorylationRRSVSELSLQGRRRR
HHHHHHHHHHHHHHH		18.0026846344
382PhosphorylationQAPSNRPYFLLLQGY
HCCCCCCEEEEEECC		12.0125072903
389PhosphorylationYFLLLQGYQDAQDFV
EEEEEECCCCHHCEE		7.1119835603
398PhosphorylationDAQDFVVYVMTREQH
CHHCEEEEEEECCEE		4.5325072903
401PhosphorylationDFVVYVMTREQHVFG
CEEEEEEECCEEECC		22.4719835603
413PhosphorylationVFGRGGNSSGRGGSP
ECCCCCCCCCCCCCC		37.1323403867
414PhosphorylationFGRGGNSSGRGGSPA
CCCCCCCCCCCCCCC		36.1923403867
419PhosphorylationNSSGRGGSPAPYVDT
CCCCCCCCCCCCCCC		22.2526846344
423PhosphorylationRGGSPAPYVDTFLNA
CCCCCCCCCCCCCCC		17.0523403867
426PhosphorylationSPAPYVDTFLNAPDI
CCCCCCCCCCCCCCC		21.7028857561
439PhosphorylationDILPRHCTVRAGPEH
CCCCCCCEECCCCCC		13.60-
537PhosphorylationRGEALAAYLDGREPV
HHHHHHHHHCCCCCE		10.3430257219
567PhosphorylationVRAAAAGSGDLPPLG
HHHHHCCCCCCCCCC		25.1425332170
607UbiquitinationGRLARLIKEAVWEKI
HHHHHHHHHHHHHHH		44.18-
613UbiquitinationIKEAVWEKIKEIGDR
HHHHHHHHHHHHCCC		43.28-
658PhosphorylationANTTELLSFVQEKVL
HCHHHHHHHHHHHHH		35.6824247654
833PhosphorylationTEFFRKLSMAVNLLC
HHHHHHHHHHHHHHC		14.02-
844PhosphorylationNLLCVPRTSLLKASW
HHHCCCCHHHHHHHH		20.04-
845PhosphorylationLLCVPRTSLLKASWS
HHCCCCHHHHHHHHH		32.7424719451
848UbiquitinationVPRTSLLKASWSSLR
CCCHHHHHHHHHHHC		45.74-
850PhosphorylationRTSLLKASWSSLRTD
CHHHHHHHHHHHCCC		26.3823403867
961PhosphorylationRHGPPVATSP-----
CCCCCCCCCC-----		41.5929396449
962PhosphorylationHGPPVATSP------
CCCCCCCCC------		20.9023403867
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RAIN_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RAIN_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RAIN_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RASH_HUMANHRASphysical
15031288
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RAIN_HUMAN

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Related Literatures of Post-Translational Modification

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