KMT2B_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KMT2B_MOUSE
• UniProt AC: O08550
• Protein Name: Histone-lysine N-methyltransferase 2B
• Gene Name: Kmt2b
• Organism: Mus musculus (Mouse).
• Sequence Length: 2713
• Subcellular Localization: Nucleus.
• Protein Description: Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2 (By similarity). Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development. Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation..
• Protein Sequence: MAAAAGGGSCPGPGSARGRFPGRPRGSGGGGGRGGRGNGAERVRVALRRGGGAAGPGGAEPGEDTALLRLLGLRRGLRRLRRLWAGARVQRGRGRGRGRGWGPNRGCMPEEESSDGESEEEEFQGFHSDEDVAPSSLRSALRSQRGRAPRGRGRKHKTTPLPPRLADVTPVPPKAPTRKRGEEGTERMVQALTELLRRSQAPQPPRSRARAREPSTPRRSRGRPPGRPAGPCRKKQQAVVLAEAAVTIPKPEPPPPVVPVKNKAGSWKCKEGPGPGPGTPKRGGQPGRGGRGGRGRGRGGLPLMIKFVSKAKKVKMGQLSQELESGQGHGQRGESWQDAPQRKDGDEPERGSCRKKQEQKLEEEEEEEEKEGEEKEEKDDNEDNNKQEEEEETERAVAEEEAMLAKEKEEAKLPSPPLTPPVPSPPPPLPPPSTSPPPPASPLPPPVSPPPPLSPPPYPAPEKQEESPPLVPATCSRKRGRPPLTPSQRAEREAARSGPEGTLSPTPNPSTTTGSPLEDSPTVVPKSTTFLKNIRQFIMPVVSARSSRVIKTPRRFMDEDPPKPPKVEASIVRPPVATSPPAPQEPVPVSSPPRVPTPPSTPVPLPEKRRSILREPTFRWTSLTRELPPPPPAPPPAPSPPPAPATPSRRPLLLRAPQFTPSEAHLKIYESVLTPPPLGALETPEPELPPADDSPAEPEPRAVGRTNHLSLPRFVPVVTSPVKVEVPPHGAPALSEGQQLQLQQPPQALQTQLLPQALPPQQPQAQPPPSPQHTPPLEKARVASLGSLPLSGVEEKMFSLLKRAKVQLFKIDQQQQQKVAASMPLSPAVQTEEAVGTVKQTPDRGCVRSEDESMEAKRDRASGPESPLQGPRIKHVCRHAAVALGQARAMVPEDVPRLSALPLRDRQDLATEDTSSASETESVPSRSQREKVESAGPGGDSEPTGSTGALAHTPRRSLPSHHGKKMRMARCGHCRGCLRVQDCGSCVNCLDKPKFGGPNTKKQCCVYRKCDKIEARKMERLAKKGRTIVKTLLPWDSDESPEASPGPPGPRRGAGAGGSREEVGATPGPEEQDSLLLQRKSARRCVKQRPSYDVFEDSDDSEPGGPPAPRRRTPREHELPVLEPEEQSRPRKPTLQPVLQLKARRRLDKDALAPGPFASFPNGWTGKQKSPDGVHRVRVDFKEDCDLENVWLMGGLSVLTSVPGGPPMVCLLCASKGLHELVFCQVCCDPFHPFCLEEAERPSPQHRDTWCCRRCKFCHVCGRKGRGSKHLLECERCRHAYHPACLGPSYPTRATRRRRHWICSACVRCKSCGATPGKNWDVEWSGDYSLCPRCTELYEKGNYCPICTRCYEDNDYESKMMQCAQCDHWVHAKCEGLSDEDYEILSGLPDSVLYTCGPCAGATQPRWREALSGALQGGLRQVLQGLLSSKVAGPLLLCTQCGQDGKQLHPGPCDLQAVGKRFEEGLYKSVHSFMEDVVAILMRHSEEGETPERRAGSQMKGLLLKLLESAFCWFDAHDPKYWRRSTRLPNGVLPNAVLPPSLDHVYAQWRQQESETPESGQPPGDPSAAFQSKDPAAFSHLDDPRQCALCLKYGDADSKEAGRLLYIGQNEWTHVNCAIWSAEVFEENDGSLKNVHAAVARGRQMRCELCLKPGATVGCCLSSCLSNFHFMCARASYCIFQDDKKVFCQKHTDLLDGKEIVTPDGFDVLRRVYVDFEGINFKRKFLTGLEPDVINVLIGSIRINSLGTLSDLSDCEGRLFPIGYQCSRLYWSTVDARRRCWYRCRILEYRPWGPREEPVHLEAAEENQTIVHSPTPSSDTDSLIPGDPVHHSPIQNLDPPLRTDSSNGPPPTPRSFSGARIKVPNYSPSRRPLGGVSFGPLPSPGSPSSLTHHIPTVGDSDFPAPPRRSRRPSPLATRPPPSRRTSSPLRTSPQLRVPLSTSVTALTPTSGELAPPDLAPSPLPPSEDLGPDFEDMEVVSGLSAADLDFAASLLGTEPFQEEIVAAGAVGSSQGGPGDSSEEEASPTTHYVHFPVTVVSGPALAPSSLAGAPRIEQLDGVDDGTDSEAEAVQQPRGQGTPPSGPGVGRGGVLGAAGDRAQPPEDLPSEIVDFVLKNLGGPGEGAAGPREDSLPSAPPLANGSQPPQSLSTSPADPTRTFAWLPGAPGVRVLSLGPAPEPPKPATSKIILVNKLGQVFVKMAGEGEPVAPPVKQPPLPPIIPPTAPTSWTLPPGPLLSVLPVVGVGVVRPAPPPPPPPLTLVFSSGPPSPPRQAIRVKRVSTFSGRSPPVPPPNKTPRLDEDGESLEDAHHVPGISGSGFSRVRMKTPTVRGVLDLNNPGEQPEEESPGRPQDRCPLLPLAEAPSQALDGSSDLLFESQWHHYSAGEASSSEEEPPSPEDKENQVPKRVGPHLRFEISSDDGFSVEAESLEVAWRTLIEKVQEARGHARLRHLSFSGMSGARLLGIHHDAVIFLAEQLPGAQRCQHYKFRYHQQGEGQEEPPLNPHGAARAEVYLRKCTFDMFNFLASQHRVLPEGATCDEEEDEVQLRSTRRATSLELPMAMRFRHLKKTSKEAVGVYRSAIHGRGLFCKRNIDAGEMVIEYSGIVIRSVLTDKREKFYDGKGIGCYMFRMDDFDVVDATMHGNAARFINHSCEPNCFSRVIHVEGQKHIVIFALRRILRGEELTYDYKFPIEDASNKLPCNCGAKRCRRFLN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAAAGGGS ------CCCCCCCCC		-
113	Phosphorylation	GCMPEEESSDGESEE CCCCHHHCCCCCCHH		21149613
114	Phosphorylation	CMPEEESSDGESEEE CCCHHHCCCCCCHHH		21149613
118	Phosphorylation	EESSDGESEEEEFQG HHCCCCCCHHHHHCC		21149613
128	Phosphorylation	EEFQGFHSDEDVAPS HHHCCCCCCCCCCCH		21149613
135	Phosphorylation	SDEDVAPSSLRSALR CCCCCCCHHHHHHHH		21149613
136	Phosphorylation	DEDVAPSSLRSALRS CCCCCCHHHHHHHHH		21149613
139	Phosphorylation	VAPSSLRSALRSQRG CCCHHHHHHHHHCCC		22942356
185	Phosphorylation	RKRGEEGTERMVQAL CCCCHHHHHHHHHHH		21183079
212	Methylation	PRSRARAREPSTPRR CCHHHHCCCCCCCCC		30988113
216	Phosphorylation	ARAREPSTPRRSRGR HHCCCCCCCCCCCCC		23384938
218	Methylation	AREPSTPRRSRGRPP CCCCCCCCCCCCCCC		30988119
219	Methylation	REPSTPRRSRGRPPG CCCCCCCCCCCCCCC		30988125
279	Phosphorylation	GPGPGPGTPKRGGQP CCCCCCCCCCCCCCC		30482847
294	Methylation	GRGGRGGRGRGRGGL CCCCCCCCCCCCCCC		16289215
296	Methylation	GGRGGRGRGRGGLPL CCCCCCCCCCCCCCH		16289223
298	Methylation	RGGRGRGRGGLPLMI CCCCCCCCCCCCHHH		30988107
320	Phosphorylation	KVKMGQLSQELESGQ CCCCCHHHHHHHCCC		17525332
467	Phosphorylation	APEKQEESPPLVPAT CCCCCCCCCCCCCCC		25266776
485	Phosphorylation	KRGRPPLTPSQRAER CCCCCCCCHHHHHHH		28066266
487	Phosphorylation	GRPPLTPSQRAEREA CCCCCCHHHHHHHHH		28066266
497	Phosphorylation	AEREAARSGPEGTLS HHHHHHHHCCCCCCC		26643407
502	Phosphorylation	ARSGPEGTLSPTPNP HHHCCCCCCCCCCCC		26643407
504	Phosphorylation	SGPEGTLSPTPNPST HCCCCCCCCCCCCCC		26745281
506	Phosphorylation	PEGTLSPTPNPSTTT CCCCCCCCCCCCCCC		26643407
510	Phosphorylation	LSPTPNPSTTTGSPL CCCCCCCCCCCCCCC		26643407
511	Phosphorylation	SPTPNPSTTTGSPLE CCCCCCCCCCCCCCC		26643407
512	Phosphorylation	PTPNPSTTTGSPLED CCCCCCCCCCCCCCC		26643407
513	Phosphorylation	TPNPSTTTGSPLEDS CCCCCCCCCCCCCCC		26643407
515	Phosphorylation	NPSTTTGSPLEDSPT CCCCCCCCCCCCCCC		26745281
520	Phosphorylation	TGSPLEDSPTVVPKS CCCCCCCCCCCCCCC		26643407
522	Phosphorylation	SPLEDSPTVVPKSTT CCCCCCCCCCCCCHH		26643407
543	Phosphorylation	QFIMPVVSARSSRVI HHHHHHHCCCCCCCC		21454597
546	Phosphorylation	MPVVSARSSRVIKTP HHHHCCCCCCCCCCC		21454597
570	Phosphorylation	KPPKVEASIVRPPVA CCCCEEEEEECCCCC		25293948
578	Phosphorylation	IVRPPVATSPPAPQE EECCCCCCCCCCCCC		25293948
579	Phosphorylation	VRPPVATSPPAPQEP ECCCCCCCCCCCCCC		21149613
590	Phosphorylation	PQEPVPVSSPPRVPT CCCCCCCCCCCCCCC		21149613
591	Phosphorylation	QEPVPVSSPPRVPTP CCCCCCCCCCCCCCC		21149613
597	Phosphorylation	SSPPRVPTPPSTPVP CCCCCCCCCCCCCCC		21659605
600	Phosphorylation	PRVPTPPSTPVPLPE CCCCCCCCCCCCCCH		28066266
601	Phosphorylation	RVPTPPSTPVPLPEK CCCCCCCCCCCCCHH		28066266
611	Phosphorylation	PLPEKRRSILREPTF CCCHHHHHHHCCCCC		30387612
614	Dimethylation	EKRRSILREPTFRWT HHHHHHHCCCCCEEE		-
614	Methylation	EKRRSILREPTFRWT HHHHHHHCCCCCEEE		54540813
622	Phosphorylation	EPTFRWTSLTRELPP CCCCEEECCCCCCCC		22006019
639	Phosphorylation	PAPPPAPSPPPAPAT CCCCCCCCCCCCCCC		27149854
646	Phosphorylation	SPPPAPATPSRRPLL CCCCCCCCCCCCCCE		25619855
662	Phosphorylation	RAPQFTPSEAHLKIY CCCCCCCCHHHHHHH		27600695
674	Phosphorylation	KIYESVLTPPPLGAL HHHHHCCCCCCCCCC		25338131
694	Phosphorylation	ELPPADDSPAEPEPR CCCCCCCCCCCCCCC		21149613
719	Phosphorylation	PRFVPVVTSPVKVEV CCCEEEECCCEEEEC		26239621
720	Phosphorylation	RFVPVVTSPVKVEVP CCEEEECCCEEEECC		26239621
784	Phosphorylation	LEKARVASLGSLPLS HHHHHHHHCCCCCCC		20139300
787	Phosphorylation	ARVASLGSLPLSGVE HHHHHCCCCCCCCHH		20139300
791	Phosphorylation	SLGSLPLSGVEEKMF HCCCCCCCCHHHHHH		28059163
822	Phosphorylation	QQQKVAASMPLSPAV HHHHHHHCCCCCHHC		28833060
826	Phosphorylation	VAASMPLSPAVQTEE HHHCCCCCHHCCCHH		27566939
831	Phosphorylation	PLSPAVQTEEAVGTV CCCHHCCCHHHCCCC		28833060
837	Phosphorylation	QTEEAVGTVKQTPDR CCHHHCCCCEECCCC		28833060
849	Phosphorylation	PDRGCVRSEDESMEA CCCCCCCCCCHHHHH		25159016
853	Phosphorylation	CVRSEDESMEAKRDR CCCCCCHHHHHHHHH		28066266
862	Phosphorylation	EAKRDRASGPESPLQ HHHHHHHCCCCCCCC		28833060
866	Phosphorylation	DRASGPESPLQGPRI HHHCCCCCCCCCHHH		23527152
911	Phosphorylation	RDRQDLATEDTSSAS CCCHHHCCCCCCCHH		28066266
914	Phosphorylation	QDLATEDTSSASETE HHHCCCCCCCHHHCC		28066266
915	Phosphorylation	DLATEDTSSASETES HHCCCCCCCHHHCCC		28066266
916	Phosphorylation	LATEDTSSASETESV HCCCCCCCHHHCCCC		28066266
918	Phosphorylation	TEDTSSASETESVPS CCCCCCHHHCCCCCC		28066266
920	Phosphorylation	DTSSASETESVPSRS CCCCHHHCCCCCCHH		28066266
922	Phosphorylation	SSASETESVPSRSQR CCHHHCCCCCCHHHH		28066266
925	Phosphorylation	SETESVPSRSQREKV HHCCCCCCHHHHHHH		28066266
934	Phosphorylation	SQREKVESAGPGGDS HHHHHHHHCCCCCCC		25619855
941	Phosphorylation	SAGPGGDSEPTGSTG HCCCCCCCCCCCCCC		26824392
944	Phosphorylation	PGGDSEPTGSTGALA CCCCCCCCCCCCCCC		25266776
946	Phosphorylation	GDSEPTGSTGALAHT CCCCCCCCCCCCCCC		28066266
947	Phosphorylation	DSEPTGSTGALAHTP CCCCCCCCCCCCCCC		28066266
953	Phosphorylation	STGALAHTPRRSLPS CCCCCCCCCCCCCCC		25619855
1009	Acetylation	KQCCVYRKCDKIEAR CCEEEEECCCHHHHH		6569077
1017	Acetylation	CDKIEARKMERLAKK CCHHHHHHHHHHHHC		6568597
1031	Phosphorylation	KGRTIVKTLLPWDSD CCCCCCHHCCCCCCC		28833060
1037	Phosphorylation	KTLLPWDSDESPEAS HHCCCCCCCCCCCCC		27149854
1040	Phosphorylation	LPWDSDESPEASPGP CCCCCCCCCCCCCCC		22942356
1044	Phosphorylation	SDESPEASPGPPGPR CCCCCCCCCCCCCCC		25293948
1066	Phosphorylation	SREEVGATPGPEEQD CHHHCCCCCCHHHHH		28066266
1091	Phosphorylation	RCVKQRPSYDVFEDS HHHHHCCCCCCCCCC		25619855
1092	Phosphorylation	CVKQRPSYDVFEDSD HHHHCCCCCCCCCCC		25619855
1098	Phosphorylation	SYDVFEDSDDSEPGG CCCCCCCCCCCCCCC		27087446
1101	Phosphorylation	VFEDSDDSEPGGPPA CCCCCCCCCCCCCCC		27087446
1170	Phosphorylation	GWTGKQKSPDGVHRV CCCCCCCCCCCCEEE		26824392
1490	Phosphorylation	RHSEEGETPERRAGS HHCCCCCCCCHHHHH		29514104
1698	Ubiquitination	HTDLLDGKEIVTPDG CCCCCCCCEEECCCC		-
1852	Phosphorylation	SSNGPPPTPRSFSGA CCCCCCCCCCCCCCC		22006019
1883	Phosphorylation	VSFGPLPSPGSPSSL CEECCCCCCCCCCHH		26160508
1886	Phosphorylation	GPLPSPGSPSSLTHH CCCCCCCCCCHHCCC		26824392
1888	Phosphorylation	LPSPGSPSSLTHHIP CCCCCCCCHHCCCCC		26160508
1889	Phosphorylation	PSPGSPSSLTHHIPT CCCCCCCHHCCCCCC		26160508
1891	Phosphorylation	PGSPSSLTHHIPTVG CCCCCHHCCCCCCCC		26160508
1896	Phosphorylation	SLTHHIPTVGDSDFP HHCCCCCCCCCCCCC		26160508
1900	Phosphorylation	HIPTVGDSDFPAPPR CCCCCCCCCCCCCCC		26160508
1913	Phosphorylation	PRRSRRPSPLATRPP CCCCCCCCCCCCCCC		25159016
1917	Phosphorylation	RRPSPLATRPPPSRR CCCCCCCCCCCCCCC		25159016
1922	Phosphorylation	LATRPPPSRRTSSPL CCCCCCCCCCCCCCC		25159016
1925	Phosphorylation	RPPPSRRTSSPLRTS CCCCCCCCCCCCCCC		21743459
1926	Phosphorylation	PPPSRRTSSPLRTSP CCCCCCCCCCCCCCC		25266776
1927	Phosphorylation	PPSRRTSSPLRTSPQ CCCCCCCCCCCCCCC		21082442
1931	Phosphorylation	RTSSPLRTSPQLRVP CCCCCCCCCCCCCCC		21082442
1932	Phosphorylation	TSSPLRTSPQLRVPL CCCCCCCCCCCCCCC		21082442
2064	Phosphorylation	LDGVDDGTDSEAEAV CCCCCCCCCHHHHHH		21149613
2066	Phosphorylation	GVDDGTDSEAEAVQQ CCCCCCCHHHHHHHC		21149613
2079	Phosphorylation	QQPRGQGTPPSGPGV HCCCCCCCCCCCCCC		26824392
2150	Phosphorylation	QPPQSLSTSPADPTR CCCCCCCCCCCCCCC		25338131
2151	Phosphorylation	PPQSLSTSPADPTRT CCCCCCCCCCCCCCE		28576409
2268	Phosphorylation	VFSSGPPSPPRQAIR EECCCCCCCCHHEEE		25293948
2281	Phosphorylation	IRVKRVSTFSGRSPP EEEEEEEECCCCCCC		29895711
2283	Phosphorylation	VKRVSTFSGRSPPVP EEEEEECCCCCCCCC		25266776
2286	Phosphorylation	VSTFSGRSPPVPPPN EEECCCCCCCCCCCC		25266776
2304	Phosphorylation	RLDEDGESLEDAHHV CCCCCCCCHHHHCCC		25338131
2346	Phosphorylation	GEQPEEESPGRPQDR CCCCCCCCCCCCCCC		26824392
2435	Phosphorylation	SLEVAWRTLIEKVQE HHHHHHHHHHHHHHH		26239621
2453	Phosphorylation	HARLRHLSFSGMSGA CCCCCCEEECCCCCC		29895711
2696	Phosphorylation	KFPIEDASNKLPCNC CCCHHHCCCCCCCCC		18266315

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KMT2B_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KMT2B_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KMT2B_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
H33_MOUSE	H3f3a	physical	17707229

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.