dbPTM

FBXW4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	FBXW4_MOUSE
UniProt AC	Q9JMJ2
Protein Name	F-box/WD repeat-containing protein 4
Gene Name	Fbxw4
Organism	Mus musculus (Mouse).
Sequence Length	410
Subcellular Localization
Protein Description	Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Likely to be involved in key signaling pathways crucial for normal limb development. May participate in Wnt signaling..
Protein Sequence	MAEDAAEDAAAAAVEPATRPAAGPALWRLPEELLLLICSYLDTRALGRLAQVCRWLRRFTSCDLLWRPIARASLNTGFTRLGTDLMAGIPVKERVKLSQNWRLGRCRDRILLKWRYSQMPWMQLQDASLYLSQANFILAYQFRPDGASLNRRPFRVFSGHDEDVCHFVLANSHIVSAGGDGKIGVHKIHSTFTVKYSAHEQEVNCVDCKGGIIVSGSRDRTAKVWPLASGRLGQCLHTIQTEDRVWSIAISPLLSSFVTGTACCGHFSPLRIWDLNSGQLITHLGSDFPPGAGVLDVMYESPSTLLSCGYDTYVRYWDLRTSTRKCVMEWEEPHDSTFYCLQTDGNHLLATGSSYYGLVRLWDRRQRACLHAFSLTSTPLSSPVYCLRFTTRHLYAALSYNLHVLDFQNP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
Oops, there are no PTM records of FBXW4_MOUSE !!

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of FBXW4_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of FBXW4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of FBXW4_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
CUL1_MOUSE	Cul1	physical	11735228
SKP1_MOUSE	Skp1a	physical	11735228

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of FBXW4_MOUSE

Related Literatures of Post-Translational Modification