ATX2L_MOUSE - dbPTM
ATX2L_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ATX2L_MOUSE
UniProt AC Q7TQH0
Protein Name Ataxin-2-like protein
Gene Name Atxn2l
Organism Mus musculus (Mouse).
Sequence Length 1049
Subcellular Localization Membrane
Peripheral membrane protein. Cytoplasm . Nucleus speckle . Cytoplasmic granule . Predominantly cytoplasmic but is also detected in nuclear speckles. Component of cytoplasmic stress granules. Inhibition of methylation alters nuclear localiza
Protein Description Involved in the regulation of stress granule and P-body formation..
Protein Sequence MLKPQPPQQTSQPQQPPPTQQAVARRSPGGTSPPNGGLPGPLTATAAPPGPPAAVSPCLGPAAAAGSGLRRGAESILAASAPPQHQERPGAVAIGSVRGQTTGKGPPQSPVFEGVYNNSRMLHFLTAVVGSTCDVKVKNGTTYEGIFKTLSSKFELAVDAVHRKASEPAGGPRREDIVDTMVFKPSDVLLVHFRNVDFNYATKDKFTDSAIAMNSKVNGEHKEKVLQRWEGGDSNSDDYDLESDMSNGWDPNEMFKFNEENYGVKTTYDSSLSSYTVPLEKDNSEEFRQRELRAAQLAREIESSPQYRLRIAMENDDGRTEEEKHSAVQRQGSGRESPSLVSREGKYIPLPQRVREGPRGGVRCSSSRGGRPGLSSLPPRGPHHLDNSSPGPGSEARGINGGPSRMSPKAQRPLRGAKTLSSPSNRPSGEASVPPTSAALPFLPVGRMYPPRSPKSAAPAPVSASCPEPPIGSAVASSASIPVTSSVVDPGAGSISPASPKLSLTPTDVKELPTKEPSRNLEAQELARIAGKVPGLQNEQKRFQLEELRKFGAQFKLQPSSSPETGLDPFPSRILKEEAKGKEKEVDGLLTSDPMGSPVSSKTESILDKEDKVPMAGVGGTEGPEQLPAPCPSQTGSPPVGLIKGDEKEEGPVTEQVKKSTLNPNAKEFNPTKPLLSVNKSTSTPTSPGPRTHSTPSIPVLTAGQSGLYSPQYISYIPQIHMGPAVQAPQMYPYPVSNSVPGQQGKYRGAKGSLPPQRSDQHQPASAPPMMQAAAAAAGPPLVAATPYSSYIPYNPQQFPGQPAMMQPMAHYPSQPVFAPMLQSNPRMLTSGSHPQAIVSSSTPQYPAAEQPTPQALYATVHQSYPHHATQLHGHQPQPATTPTGSQPQSQHAAPSPVQHQAGQAPHLGSGQPQQNLYHPGALTGTPPSLPPGPSAQSPQSSFPQPAAVYAIHPHQQLPHGFTNMAHVTQAHVQTGVTAAPPPHPGAPHPPQVMLLHPPQGHGGPPQGAVPPSGVPALSASTPSPYPYIGHPQVQSHPSQQLPFHPPGN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MLKPQPPQ
-------CCCCCCCC		45.87-
27PhosphorylationQQAVARRSPGGTSPP
HHHHHHCCCCCCCCC		23.4924925903
31PhosphorylationARRSPGGTSPPNGGL
HHCCCCCCCCCCCCC		43.9324925903
32PhosphorylationRRSPGGTSPPNGGLP
HCCCCCCCCCCCCCC		41.4524925903
43PhosphorylationGGLPGPLTATAAPPG
CCCCCCCEEECCCCC		25.7024925903
45PhosphorylationLPGPLTATAAPPGPP
CCCCCEEECCCCCCC		20.3724925903
56PhosphorylationPGPPAAVSPCLGPAA
CCCCCCCCCCCCHHH		12.7425619855
67PhosphorylationGPAAAAGSGLRRGAE
CHHHHCCCCHHHHHH		29.9025619855
96PhosphorylationPGAVAIGSVRGQTTG
CCCEEEECCCCCCCC		11.5229176673
101PhosphorylationIGSVRGQTTGKGPPQ
EECCCCCCCCCCCCC		40.1025619855
102PhosphorylationGSVRGQTTGKGPPQS
ECCCCCCCCCCCCCC		29.0725619855
109PhosphorylationTGKGPPQSPVFEGVY
CCCCCCCCCCEECCC		28.8924925903
109 (in isoform 2)Phosphorylation-28.8919144319
116PhosphorylationSPVFEGVYNNSRMLH
CCCEECCCCCHHHHH		21.3425619855
119PhosphorylationFEGVYNNSRMLHFLT
EECCCCCHHHHHHHH		18.5425619855
166PhosphorylationDAVHRKASEPAGGPR
HHHHHHHCCCCCCCC		47.3422942356
200PhosphorylationFRNVDFNYATKDKFT
EECCCCCCCCCCCCC		18.6825367039
202PhosphorylationNVDFNYATKDKFTDS
CCCCCCCCCCCCCCC		29.4325367039
205AcetylationFNYATKDKFTDSAIA
CCCCCCCCCCCCHHH		52.2823806337
234PhosphorylationQRWEGGDSNSDDYDL
HHHCCCCCCCCCCCC		41.3221743459
236PhosphorylationWEGGDSNSDDYDLES
HCCCCCCCCCCCCHH		35.4921743459
239PhosphorylationGDSNSDDYDLESDMS
CCCCCCCCCCHHHHC		27.6725293948
243PhosphorylationSDDYDLESDMSNGWD
CCCCCCHHHHCCCCC		46.0025293948
262PhosphorylationFKFNEENYGVKTTYD
HCCCHHHCCCEEEEC		26.9515879432
266PhosphorylationEENYGVKTTYDSSLS
HHHCCCEEEECCCCC		28.3425367039
267PhosphorylationENYGVKTTYDSSLSS
HHCCCEEEECCCCCC		21.4425367039
268PhosphorylationNYGVKTTYDSSLSSY
HCCCEEEECCCCCCE		21.0425367039
270PhosphorylationGVKTTYDSSLSSYTV
CCEEEECCCCCCEEE		23.8225367039
271PhosphorylationVKTTYDSSLSSYTVP
CEEEECCCCCCEEEE		29.4025367039
273PhosphorylationTTYDSSLSSYTVPLE
EEECCCCCCEEEECC		24.2125367039
274PhosphorylationTYDSSLSSYTVPLEK
EECCCCCCEEEECCC		30.0725367039
275PhosphorylationYDSSLSSYTVPLEKD
ECCCCCCEEEECCCC		14.3725367039
276PhosphorylationDSSLSSYTVPLEKDN
CCCCCCEEEECCCCC		20.0025367039
303PhosphorylationQLAREIESSPQYRLR
HHHHHHHCCCCEEEE		53.6423984901
304PhosphorylationLAREIESSPQYRLRI
HHHHHHCCCCEEEEE		11.8426824392
307PhosphorylationEIESSPQYRLRIAME
HHHCCCCEEEEEEEE		18.2629233185
326PhosphorylationRTEEEKHSAVQRQGS
CCHHHHHHHHHHCCC		41.0020469934
333PhosphorylationSAVQRQGSGRESPSL
HHHHHCCCCCCCCCC		26.7525521595
337PhosphorylationRQGSGRESPSLVSRE
HCCCCCCCCCCCCCC		20.5927087446
337 (in isoform 2)Phosphorylation-20.5919144319
339PhosphorylationGSGRESPSLVSREGK
CCCCCCCCCCCCCCC		51.1622942356
342PhosphorylationRESPSLVSREGKYIP
CCCCCCCCCCCCEEC		29.8827149854
347PhosphorylationLVSREGKYIPLPQRV
CCCCCCCEECCCHHH		20.7329514104
359Asymmetric dimethylarginineQRVREGPRGGVRCSS
HHHCCCCCCCCCCCC		66.41-
359MethylationQRVREGPRGGVRCSS
HHHCCCCCCCCCCCC		66.41-
388PhosphorylationGPHHLDNSSPGPGSE
CCCCCCCCCCCCCCC		37.2626824392
389PhosphorylationPHHLDNSSPGPGSEA
CCCCCCCCCCCCCCC		39.8827087446
394PhosphorylationNSSPGPGSEARGING
CCCCCCCCCCCCCCC		31.0825619855
397MethylationPGPGSEARGINGGPS
CCCCCCCCCCCCCCC		42.33-
404PhosphorylationRGINGGPSRMSPKAQ
CCCCCCCCCCCHHHC		43.8423684622
407PhosphorylationNGGPSRMSPKAQRPL
CCCCCCCCHHHCCCC		23.3427087446
419PhosphorylationRPLRGAKTLSSPSNR
CCCCCCCCCCCCCCC		31.1925293948
419 (in isoform 2)Phosphorylation-31.1923984901
419 (in isoform 3)Phosphorylation-31.1923984901
421PhosphorylationLRGAKTLSSPSNRPS
CCCCCCCCCCCCCCC		45.4925293948
421 (in isoform 2)Phosphorylation-45.4926239621
421 (in isoform 3)Phosphorylation-45.4926239621
422PhosphorylationRGAKTLSSPSNRPSG
CCCCCCCCCCCCCCC		35.1525266776
422 (in isoform 2)Phosphorylation-35.1526239621
422 (in isoform 3)Phosphorylation-35.1526239621
424PhosphorylationAKTLSSPSNRPSGEA
CCCCCCCCCCCCCCC		47.6326643407
424 (in isoform 2)Phosphorylation-47.6326239621
424 (in isoform 3)Phosphorylation-47.6326239621
428PhosphorylationSSPSNRPSGEASVPP
CCCCCCCCCCCCCCC		46.1325293948
428 (in isoform 2)Phosphorylation-46.1324453211
428 (in isoform 3)Phosphorylation-46.1324453211
432PhosphorylationNRPSGEASVPPTSAA
CCCCCCCCCCCCCCC		30.7426643407
432 (in isoform 2)Phosphorylation-30.7429472430
432 (in isoform 3)Phosphorylation-30.7429472430
436O-linked_GlycosylationGEASVPPTSAALPFL
CCCCCCCCCCCCCCC		25.5728528544
436PhosphorylationGEASVPPTSAALPFL
CCCCCCCCCCCCCCC		25.5725293948
436 (in isoform 2)Phosphorylation-25.5721183079
436 (in isoform 3)Phosphorylation-25.5721183079
437PhosphorylationEASVPPTSAALPFLP
CCCCCCCCCCCCCCC		19.8125293948
437 (in isoform 2)Phosphorylation-19.8121183079
437 (in isoform 3)Phosphorylation-19.8121183079
443 (in isoform 2)Phosphorylation-2.9522871156
443 (in isoform 3)Phosphorylation-2.9522871156
447 (in isoform 2)Phosphorylation-22.9925266776
447 (in isoform 3)Phosphorylation-22.9925266776
449PhosphorylationFLPVGRMYPPRSPKS
CCCCCCCCCCCCCCC		14.5528285833
453PhosphorylationGRMYPPRSPKSAAPA
CCCCCCCCCCCCCCC		42.3125521595
456PhosphorylationYPPRSPKSAAPAPVS
CCCCCCCCCCCCCCC		32.8025619855
463PhosphorylationSAAPAPVSASCPEPP
CCCCCCCCCCCCCCC		17.2625619855
465PhosphorylationAPAPVSASCPEPPIG
CCCCCCCCCCCCCCC		23.7725619855
473PhosphorylationCPEPPIGSAVASSAS
CCCCCCCCCHHHCCC		21.9325619855
477PhosphorylationPIGSAVASSASIPVT
CCCCCHHHCCCCCCC		21.6025619855
478PhosphorylationIGSAVASSASIPVTS
CCCCHHHCCCCCCCC		19.1225619855
480PhosphorylationSAVASSASIPVTSSV
CCHHHCCCCCCCCCC		29.4025619855
484PhosphorylationSSASIPVTSSVVDPG
HCCCCCCCCCCCCCC		15.2125619855
485PhosphorylationSASIPVTSSVVDPGA
CCCCCCCCCCCCCCC		22.7525619855
486PhosphorylationASIPVTSSVVDPGAG
CCCCCCCCCCCCCCC		19.4525619855
494PhosphorylationVVDPGAGSISPASPK
CCCCCCCCCCCCCCC		21.2525619855
496PhosphorylationDPGAGSISPASPKLS
CCCCCCCCCCCCCCC		18.9923684622
499PhosphorylationAGSISPASPKLSLTP
CCCCCCCCCCCCCCC		26.4225521595
503PhosphorylationSPASPKLSLTPTDVK
CCCCCCCCCCCCCHH		36.0025521595
505PhosphorylationASPKLSLTPTDVKEL
CCCCCCCCCCCHHHC		22.2925521595
507PhosphorylationPKLSLTPTDVKELPT
CCCCCCCCCHHHCCC		48.4628725479
514PhosphorylationTDVKELPTKEPSRNL
CCHHHCCCCCCCCCH		61.7425777480
518PhosphorylationELPTKEPSRNLEAQE
HCCCCCCCCCHHHHH		34.5925777480
560PhosphorylationAQFKLQPSSSPETGL
CCEECCCCCCCCCCC		30.4124925903
561PhosphorylationQFKLQPSSSPETGLD
CEECCCCCCCCCCCC		57.5024925903
562PhosphorylationFKLQPSSSPETGLDP
EECCCCCCCCCCCCC		30.9724925903
565PhosphorylationQPSSSPETGLDPFPS
CCCCCCCCCCCCCCH		46.5624925903
572PhosphorylationTGLDPFPSRILKEEA
CCCCCCCHHHHHHHH		32.1225619855
576AcetylationPFPSRILKEEAKGKE
CCCHHHHHHHHCCCC		51.657725737
591PhosphorylationKEVDGLLTSDPMGSP
CCCCCCCCCCCCCCC		35.8124925903
592PhosphorylationEVDGLLTSDPMGSPV
CCCCCCCCCCCCCCC		39.4224925903
597PhosphorylationLTSDPMGSPVSSKTE
CCCCCCCCCCCCCHH		18.8424925903
600PhosphorylationDPMGSPVSSKTESIL
CCCCCCCCCCHHHHC		29.5124925903
601PhosphorylationPMGSPVSSKTESILD
CCCCCCCCCHHHHCC		43.7824925903
603PhosphorylationGSPVSSKTESILDKE
CCCCCCCHHHHCCCC		36.5925619855
605PhosphorylationPVSSKTESILDKEDK
CCCCCHHHHCCCCCC		33.4125619855
621PhosphorylationPMAGVGGTEGPEQLP
CCCCCCCCCCCCCCC		31.6625619855
633PhosphorylationQLPAPCPSQTGSPPV
CCCCCCCCCCCCCCC		47.2824925903
635PhosphorylationPAPCPSQTGSPPVGL
CCCCCCCCCCCCCEE		43.9224925903
637PhosphorylationPCPSQTGSPPVGLIK
CCCCCCCCCCCEEEC		29.4425521595
677PhosphorylationNPTKPLLSVNKSTST
CCCCCCEEECCCCCC		31.18-
681PhosphorylationPLLSVNKSTSTPTSP
CCEEECCCCCCCCCC		23.5327087446
682PhosphorylationLLSVNKSTSTPTSPG
CEEECCCCCCCCCCC		37.9225159016
683PhosphorylationLSVNKSTSTPTSPGP
EEECCCCCCCCCCCC		39.2125521595
684PhosphorylationSVNKSTSTPTSPGPR
EECCCCCCCCCCCCC		30.5825521595
686O-linked_GlycosylationNKSTSTPTSPGPRTH
CCCCCCCCCCCCCCC		47.8791735
686PhosphorylationNKSTSTPTSPGPRTH
CCCCCCCCCCCCCCC		47.8727087446
687PhosphorylationKSTSTPTSPGPRTHS
CCCCCCCCCCCCCCC		29.1225521595
753PhosphorylationKYRGAKGSLPPQRSD
CCCCCCCCCCCCCCC		36.6820139300
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
31TPhosphorylationKinaseMTORQ9JLN9
PSP
32SPhosphorylationKinaseMTORQ9JLN9
PSP
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ATX2L_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ATX2L_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of ATX2L_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ATX2L_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry.";
Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.;
Mol. Cell. Proteomics 8:904-912(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-109, AND MASSSPECTROMETRY.
"The phagosomal proteome in interferon-gamma-activated macrophages.";
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.;
Immunity 30:143-154(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-109, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-496; SER-499 ANDSER-562, AND MASS SPECTROMETRY.
"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations.";
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.;
Mol. Cell. Proteomics 6:283-293(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-109, AND MASSSPECTROMETRY.

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