SEC13_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SEC13_MOUSE
• UniProt AC: Q9D1M0
• Protein Name: Protein SEC13 homolog {ECO:0000305}
• Gene Name: Sec13
• Organism: Mus musculus (Mouse).
• Sequence Length: 322
• Subcellular Localization: Cytoplasmic vesicle, COPII-coated vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side . Nucleus, nuclear pore complex . Lysosome membrane . In interphase,
• Protein Description: Functions as a component of the nuclear pore complex (NPC) and the COPII coat. At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles.; As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex. It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1..
• Protein Sequence: MVSVMNTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVNKGQGSVSASITEGQQNEQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MVSVMNTVD ------CCCCCCCCC	6.25	-
3	Phosphorylation	-----MVSVMNTVDT -----CCCCCCCCCC	17.85	-
10	Phosphorylation	SVMNTVDTSHEDMIH CCCCCCCCCHHHHHC	27.87	-
11	Phosphorylation	VMNTVDTSHEDMIHD CCCCCCCCHHHHHCH	22.03	-
38	Acetylation	CSSDRSVKIFDVRNG CCCCCCEEEEEECCC	38.61	22826441
87	Acetylation	DRKVIIWKEENGTWE CCEEEEEECCCCCEE	44.75	23954790
87	Ubiquitination	DRKVIIWKEENGTWE CCEEEEEECCCCCEE	44.75	-
87	Succinylation	DRKVIIWKEENGTWE CCEEEEEECCCCCEE	44.75	23954790
166	Phosphorylation	APAVVPGSLIDQPSG CCEECCCCCCCCCCC	18.97	-
175	Ubiquitination	IDQPSGQKPNYIKKF CCCCCCCCCCHHHHH	38.46	22790023
181	Acetylation	QKPNYIKKFASGGCD CCCCHHHHHHCCCCH	36.28	22826441
181	Ubiquitination	QKPNYIKKFASGGCD CCCCHHHHHHCCCCH	36.28	22790023
184	Phosphorylation	NYIKKFASGGCDNLI CHHHHHHCCCCHHHH	38.56	28066266
192	Acetylation	GGCDNLIKLWREEED CCCHHHHHHHHHCCC	45.20	22826441
203	Acetylation	EEEDGQWKEEQKLEA HCCCCCCCHHHHHHH	43.41	23954790
234	Glutathionylation	PTSTIASCSQDGRVF CCHHEEEECCCCCEE	2.90	24333276
234	S-palmitoylation	PTSTIASCSQDGRVF CCHHEEEECCCCCEE	2.90	28526873
292	Phosphorylation	KVTLWKESVDGQWVC EEEEEEECCCCEEEE	23.06	23140645
301	Phosphorylation	DGQWVCISDVNKGQG CCEEEEEEEECCCCC	30.31	23140645
309	Phosphorylation	DVNKGQGSVSASITE EECCCCCEEEEEECC	12.66	26824392
311	Phosphorylation	NKGQGSVSASITEGQ CCCCCEEEEEECCCC	20.28	23684622
313	Phosphorylation	GQGSVSASITEGQQN CCCEEEEEECCCCCC	23.65	20415495
315	Phosphorylation	GSVSASITEGQQNEQ CEEEEEECCCCCCCC	31.41	29550500

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SEC13_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SEC13_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SEC13_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SEC13_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.