dbPTM

GTSE1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	GTSE1_MOUSE
UniProt AC	Q8R080
Protein Name	G2 and S phase-expressed protein 1
Gene Name	Gtse1
Organism	Mus musculus (Mouse).
Sequence Length	741
Subcellular Localization	Cytoplasm, cytoskeleton. Associated with microtubules.
Protein Description	May be involved in p53-induced cell cycle arrest in G2/M phase by interfering with microtubule rearrangements that are required to enter mitosis. Overexpression delays G2/M phase progression..
Protein Sequence	MDAGSKKEDFLLLEDEKFDFDLSLSSSSTNEDDEVFFGPVGHKERCIAASLDLNRRVPGQPLAPGSGSPCTLSPLTGEKFVEVYKEAHLLALQIESHSRREVAQAATPQNPVNQGKETFVQDSQLKVSLFEKEQKRDRSPMSLKRETFCLPSSRVQPPMGEPQLLASPGLLSSPVSAGPAQTQSNQGLPCSSQPLPRESSTSQPPSQAGPQKRITSKLQPPRALPVRGRNLHLATEKLKKEVPASIQRTKLVNEKGSQSDVLQDKPSTAPDAASREGHPGKRSLPIPGKLGLKKTLLKPPGYTGNLTRKSSTSGSASSLESGVYRSSVAGKAKSSEQRSSIPASGSQRRTSTSKSGRIGPAASRQALPAAPARVFGRQANKADAAQTVAEQPKVPTLSPLTQQPQTPEQRGPRLDPDTETPQLNKTVSIKRRDSYLSCKTEAVSTTTNPFKVPQFSVGESPGGVTPKFSRTHRLQSWTPASRVVSSTPVRRSSGTTPQGLPGSMRTPLSTRRMSVLPTPASRRLSSLPLMAPQSMPRALVSPLCVPARRLSSEPRRRSTVRAELTQESSGSGSGGQAQGLSSDESSSPPSSVPQALNFSPEKSASPPPQGSSTGAAQGEAEPPEDTLPSEVHGGGCSHTPSEGLLLDLKLDQLTITPEAGGRDLADCPLIDFSNTPESNTALGPSSWPLIDLIMNTPDMGRNDVGKPAKAELGQLIDLGSPLIQLSPEADKENVDSPLLKF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
66	Phosphorylation	GQPLAPGSGSPCTLS CCCCCCCCCCCCCCC	34.73	22942356
68	Phosphorylation	PLAPGSGSPCTLSPL CCCCCCCCCCCCCCC	20.64	27087446
71	Phosphorylation	PGSGSPCTLSPLTGE CCCCCCCCCCCCCCC	33.38	25168779
73	Phosphorylation	SGSPCTLSPLTGEKF CCCCCCCCCCCCCCH	10.34	27087446
76	Phosphorylation	PCTLSPLTGEKFVEV CCCCCCCCCCCHHHH	46.83	25619855
107	Phosphorylation	REVAQAATPQNPVNQ HHHHHHCCCCCCCCC	28.55	25619855
139	Phosphorylation	KEQKRDRSPMSLKRE HHHHCCCCCCCCCCC	29.28	26824392
142	Phosphorylation	KRDRSPMSLKRETFC HCCCCCCCCCCCEEE	33.84	25266776
147	Phosphorylation	PMSLKRETFCLPSSR CCCCCCCEEECCCCC	24.55	25266776
153	Phosphorylation	ETFCLPSSRVQPPMG CEEECCCCCCCCCCC	34.23	-
173	Phosphorylation	ASPGLLSSPVSAGPA CCCCCCCCCCCCCCC	29.32	22006019
182	Phosphorylation	VSAGPAQTQSNQGLP CCCCCCCCCCCCCCC	35.75	22942356
184	Phosphorylation	AGPAQTQSNQGLPCS CCCCCCCCCCCCCCC	34.21	24453211
191	Phosphorylation	SNQGLPCSSQPLPRE CCCCCCCCCCCCCCC	30.02	-
200	Phosphorylation	QPLPRESSTSQPPSQ CCCCCCCCCCCCCHH	27.59	25266776
245	Phosphorylation	LKKEVPASIQRTKLV HHHHCCHHHHHHCCC	17.12	-
257	Phosphorylation	KLVNEKGSQSDVLQD CCCCCCCCHHHHCCC	37.26	30387612
259	Phosphorylation	VNEKGSQSDVLQDKP CCCCCCHHHHCCCCC	31.23	25266776
283	Phosphorylation	EGHPGKRSLPIPGKL CCCCCCCCCCCCCCC	41.82	22006019
289	Acetylation	RSLPIPGKLGLKKTL CCCCCCCCCCCCEEE	33.74	23806337
310	Phosphorylation	TGNLTRKSSTSGSAS CCCCCCCCCCCCCCH	35.24	27149854
311	Phosphorylation	GNLTRKSSTSGSASS CCCCCCCCCCCCCHH	29.63	27149854
312	Phosphorylation	NLTRKSSTSGSASSL CCCCCCCCCCCCHHH	44.17	25619855
313	Phosphorylation	LTRKSSTSGSASSLE CCCCCCCCCCCHHHH	32.47	25619855
315	Phosphorylation	RKSSTSGSASSLESG CCCCCCCCCHHHHHC	25.42	25619855
317	Phosphorylation	SSTSGSASSLESGVY CCCCCCCHHHHHCCC	36.83	25619855
318	Phosphorylation	STSGSASSLESGVYR CCCCCCHHHHHCCCH	35.55	25619855
321	Phosphorylation	GSASSLESGVYRSSV CCCHHHHHCCCHHHH	38.56	26643407
324	Phosphorylation	SSLESGVYRSSVAGK HHHHHCCCHHHHCCC	14.33	26643407
326	Phosphorylation	LESGVYRSSVAGKAK HHHCCCHHHHCCCCC	16.10	26643407
327	Phosphorylation	ESGVYRSSVAGKAKS HHCCCHHHHCCCCCC	13.64	26643407
339	Phosphorylation	AKSSEQRSSIPASGS CCCHHHHHCCCCCCC	32.11	25338131
340	Phosphorylation	KSSEQRSSIPASGSQ CCHHHHHCCCCCCCC	34.48	25338131
344	Phosphorylation	QRSSIPASGSQRRTS HHHCCCCCCCCCCCC	33.35	25338131
346	Phosphorylation	SSIPASGSQRRTSTS HCCCCCCCCCCCCCC	20.30	29514104
351	Phosphorylation	SGSQRRTSTSKSGRI CCCCCCCCCCCCCCC	28.95	-
352	Phosphorylation	GSQRRTSTSKSGRIG CCCCCCCCCCCCCCC	39.29	-
353	Phosphorylation	SQRRTSTSKSGRIGP CCCCCCCCCCCCCCC	25.29	-
396	Phosphorylation	AEQPKVPTLSPLTQQ HHCCCCCCCCCCCCC	42.74	25619855
398	Phosphorylation	QPKVPTLSPLTQQPQ CCCCCCCCCCCCCCC	21.97	26824392
401	Phosphorylation	VPTLSPLTQQPQTPE CCCCCCCCCCCCCHH	28.66	25619855
406	Phosphorylation	PLTQQPQTPEQRGPR CCCCCCCCHHHCCCC	35.16	25619855
418	Phosphorylation	GPRLDPDTETPQLNK CCCCCCCCCCCCCCC	47.34	23984901
420	Phosphorylation	RLDPDTETPQLNKTV CCCCCCCCCCCCCEE	20.58	25619855
428	Phosphorylation	PQLNKTVSIKRRDSY CCCCCEEEEEECCCC	27.85	21454597
434	Phosphorylation	VSIKRRDSYLSCKTE EEEEECCCCCCEEEE	26.60	27600695
435	Phosphorylation	SIKRRDSYLSCKTEA EEEECCCCCCEEEEE	13.61	28576409
437	Phosphorylation	KRRDSYLSCKTEAVS EECCCCCCEEEEEEE	12.82	25266776
456	Phosphorylation	PFKVPQFSVGESPGG CCCCCCEECCCCCCC	24.78	25619855
460	Phosphorylation	PQFSVGESPGGVTPK CCEECCCCCCCCCCC	23.94	21082442
465	Phosphorylation	GESPGGVTPKFSRTH CCCCCCCCCCCCCCC	24.84	21082442
476	Phosphorylation	SRTHRLQSWTPASRV CCCCCCCCCCCCCCE	37.19	26824392
478	Phosphorylation	THRLQSWTPASRVVS CCCCCCCCCCCCEEE	17.77	26745281
481	Phosphorylation	LQSWTPASRVVSSTP CCCCCCCCCEEECCC	27.15	28066266
485	Phosphorylation	TPASRVVSSTPVRRS CCCCCEEECCCCCCC	26.15	28066266
486	Phosphorylation	PASRVVSSTPVRRSS CCCCEEECCCCCCCC	25.72	28066266
487	Phosphorylation	ASRVVSSTPVRRSSG CCCEEECCCCCCCCC	20.49	29895711
492	Phosphorylation	SSTPVRRSSGTTPQG ECCCCCCCCCCCCCC	23.66	25266776
493	Phosphorylation	STPVRRSSGTTPQGL CCCCCCCCCCCCCCC	38.04	25266776
495	Phosphorylation	PVRRSSGTTPQGLPG CCCCCCCCCCCCCCC	36.93	25266776
496	Phosphorylation	VRRSSGTTPQGLPGS CCCCCCCCCCCCCCC	19.69	29472430
503	Phosphorylation	TPQGLPGSMRTPLST CCCCCCCCCCCCCCC	11.80	-
509	Phosphorylation	GSMRTPLSTRRMSVL CCCCCCCCCCCCCCC	22.52	-
514	Phosphorylation	PLSTRRMSVLPTPAS CCCCCCCCCCCCCHH	20.77	26239621
518	Phosphorylation	RRMSVLPTPASRRLS CCCCCCCCCHHHHHH	27.59	28066266
521	Phosphorylation	SVLPTPASRRLSSLP CCCCCCHHHHHHCCC	21.09	22006019
525	Phosphorylation	TPASRRLSSLPLMAP CCHHHHHHCCCCCCC	28.19	26239621
526	Phosphorylation	PASRRLSSLPLMAPQ CHHHHHHCCCCCCCC	38.30	26239621
534	Phosphorylation	LPLMAPQSMPRALVS CCCCCCCCCCCHHHC	29.69	27180971
541	Phosphorylation	SMPRALVSPLCVPAR CCCCHHHCCCHHCHH	17.01	26824392
551	Phosphorylation	CVPARRLSSEPRRRS HHCHHHHCCCCCCHH	30.74	26824392
568	Phosphorylation	RAELTQESSGSGSGG EEEEECCCCCCCCCC	30.13	25619855
569	Phosphorylation	AELTQESSGSGSGGQ EEEECCCCCCCCCCC	35.90	25619855
571	Phosphorylation	LTQESSGSGSGGQAQ EECCCCCCCCCCCCC	31.56	25619855
573	Phosphorylation	QESSGSGSGGQAQGL CCCCCCCCCCCCCCC	41.26	25619855
581	Phosphorylation	GGQAQGLSSDESSSP CCCCCCCCCCCCCCC	42.44	25619855
582	Phosphorylation	GQAQGLSSDESSSPP CCCCCCCCCCCCCCC	50.90	25619855
585	Phosphorylation	QGLSSDESSSPPSSV CCCCCCCCCCCCCCC	40.90	25619855
586	Phosphorylation	GLSSDESSSPPSSVP CCCCCCCCCCCCCCC	44.83	25619855
587	Phosphorylation	LSSDESSSPPSSVPQ CCCCCCCCCCCCCCC	50.54	25619855
590	Phosphorylation	DESSSPPSSVPQALN CCCCCCCCCCCCHHC	47.56	25619855
591	Phosphorylation	ESSSPPSSVPQALNF CCCCCCCCCCCHHCC	43.52	25619855
599	Phosphorylation	VPQALNFSPEKSASP CCCHHCCCCCCCCCC	30.95	25619855
603	Phosphorylation	LNFSPEKSASPPPQG HCCCCCCCCCCCCCC	32.11	25293948
605	Phosphorylation	FSPEKSASPPPQGSS CCCCCCCCCCCCCCC	45.06	21743459
611	Phosphorylation	ASPPPQGSSTGAAQG CCCCCCCCCCCCCCC	21.34	21743459
612	Phosphorylation	SPPPQGSSTGAAQGE CCCCCCCCCCCCCCC	37.37	25293948
613	Phosphorylation	PPPQGSSTGAAQGEA CCCCCCCCCCCCCCC	32.32	25293948
656	Phosphorylation	KLDQLTITPEAGGRD EEEEEEECCCCCCCC	15.16	21149613
696	Phosphorylation	LIDLIMNTPDMGRND HHHHHHCCCCCCCCC	11.86	-
720	Phosphorylation	GQLIDLGSPLIQLSP HHHHHCCCCCEECCH	24.67	27180971
726	Phosphorylation	GSPLIQLSPEADKEN CCCCEECCHHHHHCC	12.34	26824392
736	Phosphorylation	ADKENVDSPLLKF-- HHHCCCCCCCCCC--	17.11	21149613

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
460	S	Phosphorylation	Kinase	MAPK1	P63085	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of GTSE1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of GTSE1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of GTSE1_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of GTSE1_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"The phagosomal proteome in interferon-gamma-activated macrophages."; Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.; Immunity 30:143-154(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-476, AND MASSSPECTROMETRY.	19144319 [Abstract]