TBX3_MOUSE - dbPTM
TBX3_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TBX3_MOUSE
UniProt AC P70324
Protein Name T-box transcription factor TBX3
Gene Name Tbx3
Organism Mus musculus (Mouse).
Sequence Length 741
Subcellular Localization Nucleus .
Protein Description Transcriptional repressor involved in developmental processes. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence (By similarity)..
Protein Sequence MSLSMRDPVIPGTSMAYHPFLPHRAPDFAMSAVLGHQPPFFPALTLPPNGAAALSLPGALAKPIMDQLVGAAETGIPFSSLGPQAHLRPLKTMEPEEDVEDDPKVHLEAKELWDQFHKRGTEMVITKSGRRMFPPFKVRCSGLDKKAKYILLMDIIAADDCRYKFHNSRWMVAGKADPEMPKRMYIHPDSPATGEQWMSKVVTFHKLKLTNNISDKHGFTLAFPSDHATWQGNYSFGTQTILNSMHKYQPRFHIVRANDILKLPYSTFRTYLFPETEFIAVTAYQNDKITQLKIDNNPFAKGFRDTGNGRREKRKQLTLQSMRVFEERHKKETSDESSSEQAAFNCFAQASSPAVSIVGTSNLKDLCPSEAESDAEAESKEEHGPEACDAAKISTTTAEEPGRDKGSPATRAQLFPAEPSRARDTARLDKASPDSRHSPATISSSTRVPGADERRSPGREGPVATKVDEARAIPAKDAFAPLSVQTDATAHLAQGPLPGLGFAPGLAGQQFFNGHPLFLHPGQFAMGGAFSSMAAGMGPLLATVSGASTGVSGLESTAMASAAAAQGLSGASAATLPFHLQQHVLASQGLAMSPFGSLFPYPYTYMAAAAAASTAAASSSVHRHPFLNLNSMRPRLRYSPYSIPVPVPDSSSLLATALPSMASAAGPLDGKAAALAASPASVAVDSGSELNSRSSTLSSGSVSLSPKLCSEKEAATSELQSIQRLVSGLEAKPDRSCSGSP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSLSMRDPV
------CCCCCCCCC		29.2025293948
4Phosphorylation----MSLSMRDPVIP
----CCCCCCCCCCC		12.4025293948
13PhosphorylationRDPVIPGTSMAYHPF
CCCCCCCCCHHCCCC		15.2425293948
14PhosphorylationDPVIPGTSMAYHPFL
CCCCCCCCHHCCCCC		13.8225293948
17PhosphorylationIPGTSMAYHPFLPHR
CCCCCHHCCCCCCCC		11.0325293948
163PhosphorylationIAADDCRYKFHNSRW
HHCCCCEEEECCCCE		25.0822871156
168PhosphorylationCRYKFHNSRWMVAGK
CEEEECCCCEEEECC		20.8122871156
265PhosphorylationNDILKLPYSTFRTYL
HHCEECCCCCCCCCC		30.68-
288AcetylationVTAYQNDKITQLKID
EEEEECCCCEEEEEC		56.027712689
333PhosphorylationEERHKKETSDESSSE
HHHHHCCCCCCCHHH		50.8123984901
334PhosphorylationERHKKETSDESSSEQ
HHHHCCCCCCCHHHH		40.2423984901
337PhosphorylationKKETSDESSSEQAAF
HCCCCCCCHHHHHHH		44.1223984901
338PhosphorylationKETSDESSSEQAAFN
CCCCCCCHHHHHHHH		35.5323984901
339PhosphorylationETSDESSSEQAAFNC
CCCCCCHHHHHHHHH		42.9023984901
351PhosphorylationFNCFAQASSPAVSIV
HHHHHHCCCCCEEEE		25.4423984901
352PhosphorylationNCFAQASSPAVSIVG
HHHHHCCCCCEEEEE		21.6423984901
356PhosphorylationQASSPAVSIVGTSNL
HCCCCCEEEEECCCH		17.4223984901
360PhosphorylationPAVSIVGTSNLKDLC
CCEEEEECCCHHHHC		11.9823984901
361PhosphorylationAVSIVGTSNLKDLCP
CEEEEECCCHHHHCC		33.9523984901
369PhosphorylationNLKDLCPSEAESDAE
CHHHHCCHHHHCHHH		48.7425521595
373PhosphorylationLCPSEAESDAEAESK
HCCHHHHCHHHHHHH		49.5225521595
379PhosphorylationESDAEAESKEEHGPE
HCHHHHHHHHHHCHH		53.0323984901
394PhosphorylationACDAAKISTTTAEEP
HHHHCEECCCCCCCC		20.9925777480
395PhosphorylationCDAAKISTTTAEEPG
HHHCEECCCCCCCCC		31.4725777480
396PhosphorylationDAAKISTTTAEEPGR
HHCEECCCCCCCCCC		19.7425777480
397PhosphorylationAAKISTTTAEEPGRD
HCEECCCCCCCCCCC		31.9625777480
407PhosphorylationEPGRDKGSPATRAQL
CCCCCCCCCCCHHHH		19.6626824392
410PhosphorylationRDKGSPATRAQLFPA
CCCCCCCCHHHHCCC		29.8926160508
432PhosphorylationTARLDKASPDSRHSP
CCCCCCCCCCCCCCC		34.6726824392
435PhosphorylationLDKASPDSRHSPATI
CCCCCCCCCCCCCCC		34.9626824392
438PhosphorylationASPDSRHSPATISSS
CCCCCCCCCCCCCCC		18.3426824392
441PhosphorylationDSRHSPATISSSTRV
CCCCCCCCCCCCCCC		25.4426160508
443PhosphorylationRHSPATISSSTRVPG
CCCCCCCCCCCCCCC		17.5526160508
444PhosphorylationHSPATISSSTRVPGA
CCCCCCCCCCCCCCC		31.7018846507
445PhosphorylationSPATISSSTRVPGAD
CCCCCCCCCCCCCCC		17.2818846507
446PhosphorylationPATISSSTRVPGADE
CCCCCCCCCCCCCCC		37.3218846507
456PhosphorylationPGADERRSPGREGPV
CCCCCCCCCCCCCCC		37.6225521595
465PhosphorylationGREGPVATKVDEARA
CCCCCCCCCHHHHCC		31.6629899451
633MethylationFLNLNSMRPRLRYSP
CCCCCCCCCCCCCCC		17.0130989485
635MethylationNLNSMRPRLRYSPYS
CCCCCCCCCCCCCCC		22.7930989491
678PhosphorylationKAAALAASPASVAVD
HHHHHHCCCCEEEEC		18.5230352176
681PhosphorylationALAASPASVAVDSGS
HHHCCCCEEEECCCC		17.6221149613
686PhosphorylationPASVAVDSGSELNSR
CCEEEECCCCCCCCC		37.3129514104
694PhosphorylationGSELNSRSSTLSSGS
CCCCCCCCCCCCCCC		27.7425168779
695PhosphorylationSELNSRSSTLSSGSV
CCCCCCCCCCCCCCE		32.0525168779
696PhosphorylationELNSRSSTLSSGSVS
CCCCCCCCCCCCCEE		31.7225168779
698PhosphorylationNSRSSTLSSGSVSLS
CCCCCCCCCCCEECC		32.5125619855
699PhosphorylationSRSSTLSSGSVSLSP
CCCCCCCCCCEECCH		37.8925619855
701PhosphorylationSSTLSSGSVSLSPKL
CCCCCCCCEECCHHH		15.5225619855
703PhosphorylationTLSSGSVSLSPKLCS
CCCCCCEECCHHHCC		25.4825619855
705PhosphorylationSSGSVSLSPKLCSEK
CCCCEECCHHHCCHH		16.6925521595
710PhosphorylationSLSPKLCSEKEAATS
ECCHHHCCHHHHHHH		63.2425168779
727PhosphorylationQSIQRLVSGLEAKPD
HHHHHHHHCCCCCCC		42.1023984901
736PhosphorylationLEAKPDRSCSGSP--
CCCCCCCCCCCCC--		21.7323984901
738PhosphorylationAKPDRSCSGSP----
CCCCCCCCCCC----		43.4823984901
740PhosphorylationPDRSCSGSP------
CCCCCCCCC------		15.9023984901
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TBX3_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TBX3_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TBX3_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of TBX3_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TBX3_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry.";
Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.;
J. Proteome Res. 6:250-262(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-373, AND MASSSPECTROMETRY.

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