| UniProt ID | NR0B1_MOUSE | |
|---|---|---|
| UniProt AC | Q61066 | |
| Protein Name | Nuclear receptor subfamily 0 group B member 1 | |
| Gene Name | Nr0b1 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 472 | |
| Subcellular Localization | Nucleus. Cytoplasm. Shuttles between the cytoplasm and nucleus. Homodimers exits in the cytoplasm and in the nucleus (By similarity).. | |
| Protein Description | Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity).. | |
| Protein Sequence | MAGEDHPWQGSILYNLLMSAKQKHASQEEREVRLGAQCWGCACGAQPVLGGERLSGGQARSLLYRCCFCGENHPRQGGILYSMLTNARQPSVATQAPRARFGAPCWGCACGSAEPLVGREGLPAGQAPSLLYRCCFCGEEHPRQGSILYSLLTSAQQTHVSREAPEAHRRGEWWQLSYCTQSVGGPEGLQSTQAMAFLYRSYVCGEEQPQQISVASGTPVSADQTPATPQEQPRAPWWDASPGVQRLITLKDPQVVCEAASAGLLKTLRFVKYLPCFQILPLDQQLVLVRSCWAPLLMLELAQDHLHFEMMEIPETNTTQEMLTTRRQETEGPEPAEPQATEQPQMVSAEAGHLLPAAAVQAIKSFFFKCWSLNIDTKEYAYLKGTVLFNPDLPGLQCVKYIEGLQWRTQQILTEHIRMMQREYQIRSAELNSALFLLRFINSDVVTELFFRPIIGAVSMDDMMLEMLCAKL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 228 | Phosphorylation | SADQTPATPQEQPRA CCCCCCCCCCCCCCC | 27.06 | 22006019 | |
| 241 | Phosphorylation | RAPWWDASPGVQRLI CCCCCCCCCCCEEEE | 21.51 | 26643407 | |
| 251 | Ubiquitination | VQRLITLKDPQVVCE CEEEEEECCHHHHHH | 59.73 | - | |
| 272 | Ubiquitination | LKTLRFVKYLPCFQI HHHHHHHHHCCHHEE | 38.06 | - | |
| 400 | Ubiquitination | LPGLQCVKYIEGLQW CCCCHHHHHHCCCHH | 48.41 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NR0B1_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NR0B1_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NR0B1_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| HNF4A_MOUSE | Hnf4a | physical | 19651776 | |
| SALL4_MOUSE | Sall4 | physical | 20362541 | |
| ERR2_MOUSE | Esrrb | physical | 20362541 | |
| SNW1_MOUSE | Snw1 | physical | 20362541 | |
| WDR5_MOUSE | Wdr5 | physical | 20362541 | |
| PO5F1_MOUSE | Pou5f1 | physical | 20362541 | |
| ANM1_MOUSE | Prmt1 | physical | 20362541 | |
| RIF1_MOUSE | Rif1 | physical | 20362541 | |
| OGT1_MOUSE | Ogt | physical | 20362541 | |
| ZN609_MOUSE | Zfp609 | physical | 17093407 | |
| PELO_MOUSE | Pelo | physical | 17093407 | |
| REST_MOUSE | Rest | physical | 17093407 | |
| SP1_MOUSE | Sp1 | physical | 17093407 | |
| ERR2_MOUSE | Esrrb | physical | 17093407 | |
| SALL4_MOUSE | Sall4 | physical | 17093407 | |
| TIF1B_MOUSE | Trim28 | physical | 17093407 | |
| RIF1_MOUSE | Rif1 | physical | 17093407 | |
| NANOG_MOUSE | Nanog | physical | 17093407 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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