PELO_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PELO_MOUSE
• UniProt AC: Q80X73
• Protein Name: Protein pelota homolog
• Gene Name: Pelo
• Organism: Mus musculus (Mouse).
• Sequence Length: 385
• Subcellular Localization: Nucleus . Cytoplasm.
• Protein Description: Required for normal chromosome segregation during cell division and genomic stability. May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs. May have ribonuclease activity (Potential)..
• Protein Sequence: MKLVRKDIEKDNAGQVTLVPEEPEDMWHTFNLVQVGDSLRASTIRKVQTESSTGSVGSNRVRTTLTLCVEAIDFDSQACQLRVKGTNIQENEYVKMGAYHTIELEPNRQFTLAKKQWDSVVLERIEQACDPAWSADVAAVVMQEGLAHVCLVTPSMTLTRAKVEVNIPRKRKGNCSQHDRALERFYEQVVQAIQRHINFEVVKCVLVASPGFVREQFCDYMFQQAVKTDNKVLLENRSKFLQVHASSGHKYSLKEALCDPTVASRLSDTKAAGEVKALDDFYKMLQHEPDRAFYGLKQVERANEALAIDTLLISDELFRHQDVATRSRYVRLVDSVKENAGTVRIFSSLHVSGEQLGQLTGVAAILRFPVPELSDQEDDSSSEED

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
38	Phosphorylation	NLVQVGDSLRASTIR EEEECCCHHCHHHEE	17.52	-
51	Phosphorylation	IRKVQTESSTGSVGS EEEEEECCCCCCCCC	36.27	29899451
52	Phosphorylation	RKVQTESSTGSVGSN EEEEECCCCCCCCCC	30.47	29472430
53	Phosphorylation	KVQTESSTGSVGSNR EEEECCCCCCCCCCC	42.63	29472430
55	Phosphorylation	QTESSTGSVGSNRVR EECCCCCCCCCCCCE	24.32	26824392
58	Phosphorylation	SSTGSVGSNRVRTTL CCCCCCCCCCCEEEE	21.21	29472430
99	Phosphorylation	EYVKMGAYHTIELEP CEEEECCEEEEEECC	8.18	29514104
101	Phosphorylation	VKMGAYHTIELEPNR EEECCEEEEEECCCC	11.94	-
374	Phosphorylation	RFPVPELSDQEDDSS ECCCCCCCCCCCCCC	35.27	22817900
380	Phosphorylation	LSDQEDDSSSEED-- CCCCCCCCCCCCC--	48.35	21743459
381	Phosphorylation	SDQEDDSSSEED--- CCCCCCCCCCCC---	49.08	21743459
382	Phosphorylation	DQEDDSSSEED---- CCCCCCCCCCC----	49.29	21743459

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PELO_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PELO_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PELO_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PELO_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.