ZCHC8_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZCHC8_MOUSE
• UniProt AC: Q9CYA6
• Protein Name: Zinc finger CCHC domain-containing protein 8
• Gene Name: Zcchc8
• Organism: Mus musculus (Mouse).
• Sequence Length: 709
• Subcellular Localization: Nucleus, nucleoplasm . Excluded from nucleolus.
• Protein Description: Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that directs a subset of non-coding short-lived RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters. May be involved in pre-mRNA splicing..
• Protein Sequence: MAAGVDFGDLELFEAFDPPEESTPKPVHTRFKDDEEEEDDDDDENGVGDAELQEQLRRCEATIEQLRAENQELKRKLNILTRPSGILVSNTKIDGPLLQILFMNNAISKQYHQEIEEFVSNLVKRFEEQQKNDVEKTSFSLLPQPSSVMLEEDHKVEESCAVKNNKEAFSVVGSVLYFTNFCLDKLGQPLLNENPQLTEGWEIPKYQQVFSHIVPLEGQEMQVKAKRPKPHCFNCGSEEHQMKECPMPRNAARISEKRKEYMDACGEASGQSFQQRYHAEEVEERFGRFKPGVISEELQDALGVTDKSLPPFIYRMRQLGYPPGWLKEAELENSGLALYDGNDDADGETETGEIQNKNVTYDLSKLVNYPGFNISTPRGIPDEWRMFGSIPMQACQQKDVFASYLNSNIQSPSMRSSGKRSSSQSSPNSPKKQRKEGSAAASPADMELDSDVEIPPGSQSSKAFQFQPPLPPGTPPPLPQGTPPPLFTPPLPKGTPPLTPSDSPQARPAASAMDEDALTLEELEEQQRQIWAALQQAEGGNGDSDVPGDTPLTGNSVASSPCPNEFDLPVPEGKALEKPVLAEPQEPAASVDTAGPEPSCSPAAGAAVLSQREEEAAAEGGPGDALLDNGGVLNMNMSNGSNQQPIHPDSRPPMAPKTHSPVPDMSKFATGITPFEFENMAESTGMYLRIRNLLKNSPRNQQKNKKTCE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAGVDFGD ------CCCCCCCCC	16.96	-
22	Phosphorylation	AFDPPEESTPKPVHT CCCCCCCCCCCCCCC	48.63	26643407
23	Phosphorylation	FDPPEESTPKPVHTR CCCCCCCCCCCCCCC	38.31	26643407
29	Phosphorylation	STPKPVHTRFKDDEE CCCCCCCCCCCCCCC	37.73	26643407
84	Phosphorylation	LNILTRPSGILVSNT HCHHHCCCCEEEECC	34.86	22807455
89	Phosphorylation	RPSGILVSNTKIDGP CCCCEEEECCCCCCH	35.02	22807455
91	Phosphorylation	SGILVSNTKIDGPLL CCEEEECCCCCCHHH	23.13	22807455
108	Phosphorylation	LFMNNAISKQYHQEI HHHCCHHHHHHHHHH	15.99	25777480
261	Phosphorylation	ISEKRKEYMDACGEA HHHHHHHHHHHHHHH	11.88	-
375	Phosphorylation	NYPGFNISTPRGIPD CCCCCCCCCCCCCCC	33.20	26643407
376	Phosphorylation	YPGFNISTPRGIPDE CCCCCCCCCCCCCCH	17.13	26643407
403	Phosphorylation	QQKDVFASYLNSNIQ HCHHHHHHHHCCCCC	20.77	25168779
404	Phosphorylation	QKDVFASYLNSNIQS CHHHHHHHHCCCCCC	13.38	26643407
407	Phosphorylation	VFASYLNSNIQSPSM HHHHHHCCCCCCCCH	32.49	26643407
411	Phosphorylation	YLNSNIQSPSMRSSG HHCCCCCCCCHHCCC	18.36	28725479
413	Phosphorylation	NSNIQSPSMRSSGKR CCCCCCCCHHCCCCC	31.88	25266776
416	Phosphorylation	IQSPSMRSSGKRSSS CCCCCHHCCCCCCCC	34.50	29550500
417	Phosphorylation	QSPSMRSSGKRSSSQ CCCCHHCCCCCCCCC	37.66	29550500
421	Phosphorylation	MRSSGKRSSSQSSPN HHCCCCCCCCCCCCC	37.52	27087446
422	Phosphorylation	RSSGKRSSSQSSPNS HCCCCCCCCCCCCCC	36.11	29550500
423	Phosphorylation	SSGKRSSSQSSPNSP CCCCCCCCCCCCCCC	35.02	27087446
425	Phosphorylation	GKRSSSQSSPNSPKK CCCCCCCCCCCCCHH	50.11	27087446
426	Phosphorylation	KRSSSQSSPNSPKKQ CCCCCCCCCCCCHHH	22.06	23335269
429	Phosphorylation	SSQSSPNSPKKQRKE CCCCCCCCCHHHHHC	41.29	27087446
438	Phosphorylation	KKQRKEGSAAASPAD HHHHHCCCCCCCHHH	18.80	26643407
442	Phosphorylation	KEGSAAASPADMELD HCCCCCCCHHHCCCC	18.85	26643407
450	Phosphorylation	PADMELDSDVEIPPG HHHCCCCCCCCCCCC	57.06	26643407
474	Phosphorylation	QPPLPPGTPPPLPQG CCCCCCCCCCCCCCC	38.09	26824392
482	Phosphorylation	PPPLPQGTPPPLFTP CCCCCCCCCCCCCCC	27.63	22942356
488	Phosphorylation	GTPPPLFTPPLPKGT CCCCCCCCCCCCCCC	31.51	26745281
495	Phosphorylation	TPPLPKGTPPLTPSD CCCCCCCCCCCCCCC	28.05	21082442
499	Phosphorylation	PKGTPPLTPSDSPQA CCCCCCCCCCCCCCC	26.90	21659605
501	Phosphorylation	GTPPLTPSDSPQARP CCCCCCCCCCCCCCC	45.55	20469934
503	Phosphorylation	PPLTPSDSPQARPAA CCCCCCCCCCCCCCH	24.21	27087446
511	Phosphorylation	PQARPAASAMDEDAL CCCCCCHHCCCCCCC	26.66	27087446
519	Phosphorylation	AMDEDALTLEELEEQ CCCCCCCCHHHHHHH	33.57	25293948
590	Phosphorylation	EPQEPAASVDTAGPE CCCCCCCCCCCCCCC	23.72	25619855
593	Phosphorylation	EPAASVDTAGPEPSC CCCCCCCCCCCCCCC	31.21	25619855
599	Phosphorylation	DTAGPEPSCSPAAGA CCCCCCCCCCHHHHH	26.09	25619855
601	Phosphorylation	AGPEPSCSPAAGAAV CCCCCCCCHHHHHHH	23.16	26824392
610	Phosphorylation	AAGAAVLSQREEEAA HHHHHHHHHHHHHHH	22.16	25619855
658	Phosphorylation	RPPMAPKTHSPVPDM CCCCCCCCCCCCCCH	26.91	29899451
660	Phosphorylation	PMAPKTHSPVPDMSK CCCCCCCCCCCCHHH	32.59	25521595
697	Phosphorylation	IRNLLKNSPRNQQKN HHHHHHCCCCHHHHC	24.53	25266776

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZCHC8_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
495	T	Phosphorylation	Phosphorylation at Thr-495 by GSK3 is triggered in cells entering mitosis.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZCHC8_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ZCHC8_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.