dbPTM

KAT8_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	KAT8_MOUSE
UniProt AC	Q9D1P2
Protein Name	Histone acetyltransferase KAT8
Gene Name	Kat8
Organism	Mus musculus (Mouse).
Sequence Length	458
Subcellular Localization	Nucleus. Chromosome.
Protein Description	Histone acetyltransferase which may be involved in transcriptional activation. May influence the function of ATM. As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. That activity is less specific than the one of the MSL complex. Can also acetylate TP53/p53 at 'Lys-120'..
Protein Sequence	MAAQGATAAVAATTSGTVGEGEPGPGENAAVEGPARSPGRVSPPTPARGEPEVTVEIGETYLCRRPDSTWHSAEVIQSRVNDQEGREEFYVHYVGFNRRLDEWVDKNRLALTKTVKDAVQKNSEKYLSELAEQPERKITRNQKRKHDEINHVQKTYAEMDPTTAALEKEHEAITKVKYVDKIHIGNYEIDAWYFSPFPEDYGKQPKLWLCEYCLKYMKFEKSYRFHLGQCQWRQPPGKEIYRKSNISVYEVDGKDHKIYCQNLCLLAKLFLDHKTLYFDVEPFVFYILTEVDRQGAHIVGYFSKEKESPDGNNVACILTLPPYQRRGYGKFLIAFSYELSKLESTVGSPEKPLSDLGKLSYRSYWSWVLLEILRDFRGTLSIKDLSQMTSITQNDIISTLQSLNMVKYWKGQHVICVTPKLVEEHLKSAQYKKPPITVDSVCLKWAPPKHKQVKLSKK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAQGATAA ------CCCCCCCEE	14.43	-
7	Phosphorylation	-MAAQGATAAVAATT -CCCCCCCEEEEEEC	23.21	25293948
13	Phosphorylation	ATAAVAATTSGTVGE CCEEEEEECCCCCCC	16.26	25293948
14	Phosphorylation	TAAVAATTSGTVGEG CEEEEEECCCCCCCC	22.04	25293948
15	Phosphorylation	AAVAATTSGTVGEGE EEEEEECCCCCCCCC	28.28	25293948
17	Phosphorylation	VAATTSGTVGEGEPG EEEECCCCCCCCCCC	25.71	25293948
37	Phosphorylation	AVEGPARSPGRVSPP CEECCCCCCCCCCCC	33.54	26824392
42	Phosphorylation	ARSPGRVSPPTPARG CCCCCCCCCCCCCCC	24.65	26824392
45	Phosphorylation	PGRVSPPTPARGEPE CCCCCCCCCCCCCCE	32.72	23737553
113	Acetylation	KNRLALTKTVKDAVQ HHHHHCCHHHHHHHH	52.77	-
154	Acetylation	DEINHVQKTYAEMDP HHHHHHHHHHHHCCC	42.27	22826441
168	Acetylation	PTTAALEKEHEAITK CCHHHHHHHHHHHHC	66.28	22826441
274	Acetylation	AKLFLDHKTLYFDVE HHHHCCCCCEEECCC	39.63	-
344	Phosphorylation	YELSKLESTVGSPEK EEHHHHHHCCCCCCC	38.54	26643407
345	Phosphorylation	ELSKLESTVGSPEKP EHHHHHHCCCCCCCC	21.36	26643407
348	Phosphorylation	KLESTVGSPEKPLSD HHHHCCCCCCCCHHH	26.08	26824392
351	Acetylation	STVGSPEKPLSDLGK HCCCCCCCCHHHHCC	55.43	22826441
354	Phosphorylation	GSPEKPLSDLGKLSY CCCCCCHHHHCCHHH	39.04	26643407

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of KAT8_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
274	K	Acetylation		-
Autoacetylation at Lys-274 is required for binding histone H4 with high affinity and for proper function.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of KAT8_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MSL1_MOUSE	Msl1	physical	17335777
NELFD_MOUSE	Nelfcd	physical	17335777
SYCP3_MOUSE	Sycp3	physical	20479123
KAT8_HUMAN	KAT8	physical	20360068
KANL3_HUMAN	KANSL3	physical	20360068
MSL1_HUMAN	MSL1	physical	20360068
KANL1_HUMAN	KANSL1	physical	20360068
MS3L1_HUMAN	MSL3	physical	20360068
WDR5_HUMAN	WDR5	physical	20360068
KANL2_HUMAN	KANSL2	physical	20360068
GEMI_HUMAN	GMNN	physical	20360068
MCRS1_HUMAN	MCRS1	physical	20360068
HCFC1_HUMAN	HCFC1	physical	20360068
PHF20_HUMAN	PHF20	physical	20360068
P20L1_HUMAN	PHF20L1	physical	20360068
MSL2_HUMAN	MSL2	physical	20360068
OGT1_HUMAN	OGT	physical	20360068
SIR1_MOUSE	Sirt1	physical	22586264
PHF20_MOUSE	Phf20	physical	23452852
FANCG_HUMAN	FANCG	physical	26496610
HCFC1_HUMAN	HCFC1	physical	26496610
FOXK2_HUMAN	FOXK2	physical	26496610
NDUA4_HUMAN	NDUFA4	physical	26496610
OGT1_HUMAN	OGT	physical	26496610
MCRS1_HUMAN	MCRS1	physical	26496610
NEST_HUMAN	NES	physical	26496610
MS3L1_HUMAN	MSL3	physical	26496610
WDR5_HUMAN	WDR5	physical	26496610
IQCE_HUMAN	IQCE	physical	26496610
R3HD1_HUMAN	R3HDM1	physical	26496610
P20L1_HUMAN	PHF20L1	physical	26496610
RL26L_HUMAN	RPL26L1	physical	26496610
MSL2_HUMAN	MSL2	physical	26496610
KANL3_HUMAN	KANSL3	physical	26496610
SIL1_HUMAN	SIL1	physical	26496610
ARI5B_HUMAN	ARID5B	physical	26496610
RICTR_HUMAN	RICTOR	physical	26496610
CHAP1_HUMAN	CHAMP1	physical	26496610
KANL1_HUMAN	KANSL1	physical	26496610
K2C6C_HUMAN	KRT6C	physical	26496610
MSL1_HUMAN	MSL1	physical	26496610

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of KAT8_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37 AND SER-42, AND MASSSPECTROMETRY.	17242355 [Abstract]