P20L1_HUMAN - dbPTM
P20L1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID P20L1_HUMAN
UniProt AC A8MW92
Protein Name PHD finger protein 20-like protein 1
Gene Name PHF20L1
Organism Homo sapiens (Human).
Sequence Length 1017
Subcellular Localization
Protein Description
Protein Sequence MSKKPPNRPGITFEIGARLEALDYLQKWYPSRIEKIDYEEGKMLVHFERWSHRYDEWIYWDSNRLRPLERPALRKEGLKDEEDFFDFKAGEEVLARWTDCRYYPAKIEAINKEGTFTVQFYDGVIRCLKRMHIKAMPEDAKGQVKSQHPLSWCCPIDPAGSCNQSMGSEDWIALVKAAAAAAAKNKTGSKPRTSANSNKDKDKDERKWFKVPSKKEETSTCIATPDVEKKEDLPTSSETFGLHVENVPKMVFPQPESTLSNKRKNNQGNSFQAKRARLNKITGLLASKAVGVDGAEKKEDYNETAPMLEQAISPKPQSQKKNEADISSSANTQKPALLSSTLSSGKARSKKCKHESGDSSGCIKPPKSPLSPELIQVEDLTLVSQLSSSVINKTSPPQPVNPPRPFKHSERRRRSQRLATLPMPDDSVEKVSSPSPATDGKVFSISSQNQQESSVPEVPDVAHLPLEKLGPCLPLDLSRGSEVTAPVASDSSYRNECPRAEKEDTQMLPNPSSKAIADGRGAPAAAGISKTEKKVKLEDKSSTAFGKRKEKDKERREKRDKDHYRPKQKKKKKKKKKSKQHDYSDYEDSSLEFLERCSSPLTRSSGSSLASRSMFTEKTTTYQYPRAILSVDLSGENLSDVDFLDDSSTESLLLSGDEYNQDFDSTNFEESQDEDDALNEIVRCICEMDEENGFMIQCEECLCWQHSVCMGLLEESIPEQYICYICRDPPGQRWSAKYRYDKEWLNNGRMCGLSFFKENYSHLNAKKIVSTHHLLADVYGVTEVLHGLQLKIGILKNKHHPDLHLWACSGKRKDQDQIIAGVEKKIAQDTVNREEKKYVQNHKEPPRLPLKMEGTYITSEHSYQKPQSFGQDCKSLADPGSSDDDDVSSLEEEQEFHMRSKNSLQYSAKEHGMPEKNPAEGNTVFVYNDKKGTEDPGDSHLQWQLNLLTHIENVQNEVTSRMDLIEKEVDVLESWLDFTGELEPPDPLARLPQLKRHIKQLLIDMGKVQQIATLCSV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
35UbiquitinationWYPSRIEKIDYEEGK
HCHHHCEEEECCCCC		38.21-
75MethylationLERPALRKEGLKDEE
CCCHHHHHCCCCCHH		57.91-
75SumoylationLERPALRKEGLKDEE
CCCHHHHHCCCCCHH		57.9128112733
79SumoylationALRKEGLKDEEDFFD
HHHHCCCCCHHHCCC		74.15-
79SumoylationALRKEGLKDEEDFFD
HHHHCCCCCHHHCCC		74.1528112733
79UbiquitinationALRKEGLKDEEDFFD
HHHHCCCCCHHHCCC		74.15-
106UbiquitinationDCRYYPAKIEAINKE
CCCEEECEEEEECCC		36.25-
141AcetylationKAMPEDAKGQVKSQH
ECCCCCCCCCCCCCC		63.3026051181
150 (in isoform 2)Ubiquitination-6.12-
161PhosphorylationCPIDPAGSCNQSMGS
CCCCCCCCCCCCCCC		16.41-
165PhosphorylationPAGSCNQSMGSEDWI
CCCCCCCCCCCHHHH		15.89-
168PhosphorylationSCNQSMGSEDWIALV
CCCCCCCCHHHHHHH		24.60-
187PhosphorylationAAAAKNKTGSKPRTS
HHHHHCCCCCCCCCC		56.96-
194PhosphorylationTGSKPRTSANSNKDK
CCCCCCCCCCCCCCC		27.0824719451
197PhosphorylationKPRTSANSNKDKDKD
CCCCCCCCCCCCCHH		45.00-
200UbiquitinationTSANSNKDKDKDERK
CCCCCCCCCCHHHHH		69.5021906983
211UbiquitinationDERKWFKVPSKKEET
HHHHCCCCCCCCCCC		4.7521906983
224PhosphorylationETSTCIATPDVEKKE
CCCCCEECCCCCCCC		10.5025159151
235PhosphorylationEKKEDLPTSSETFGL
CCCCCCCCCCCCCCE		52.7827732954
236PhosphorylationKKEDLPTSSETFGLH
CCCCCCCCCCCCCEE		25.0027732954
237PhosphorylationKEDLPTSSETFGLHV
CCCCCCCCCCCCEEE		43.0427732954
239PhosphorylationDLPTSSETFGLHVEN
CCCCCCCCCCEEECC		25.5827732954
258PhosphorylationVFPQPESTLSNKRKN
CCCCCCCCCCCCCCC		32.3228555341
260PhosphorylationPQPESTLSNKRKNNQ
CCCCCCCCCCCCCCC		40.1525627689
270PhosphorylationRKNNQGNSFQAKRAR
CCCCCCCCHHHHHHH		26.0928348404
274AcetylationQGNSFQAKRARLNKI
CCCCHHHHHHHHHHH		35.4925953088
288AcetylationITGLLASKAVGVDGA
HHHHHHHCCCCCCCC		41.2925953088
297AcetylationVGVDGAEKKEDYNET
CCCCCCHHCCHHHCH		62.0122361301
301PhosphorylationGAEKKEDYNETAPML
CCHHCCHHHCHHHHH		18.9128842319
304PhosphorylationKKEDYNETAPMLEQA
HCCHHHCHHHHHHHH		32.2128842319
313PhosphorylationPMLEQAISPKPQSQK
HHHHHHHCCCCCCCC		29.8630266825
318PhosphorylationAISPKPQSQKKNEAD
HHCCCCCCCCCCHHH		53.1230266825
339PhosphorylationTQKPALLSSTLSSGK
CCCCHHHHHHHHCCC		23.3325627689
340PhosphorylationQKPALLSSTLSSGKA
CCCHHHHHHHHCCCC		33.0825627689
343PhosphorylationALLSSTLSSGKARSK
HHHHHHHHCCCCCCC		36.8125159151
344PhosphorylationLLSSTLSSGKARSKK
HHHHHHHCCCCCCCC		47.6430576142
351AcetylationSGKARSKKCKHESGD
CCCCCCCCCCCCCCC		50.1630591277
356PhosphorylationSKKCKHESGDSSGCI
CCCCCCCCCCCCCCC		47.8528985074
359PhosphorylationCKHESGDSSGCIKPP
CCCCCCCCCCCCCCC		31.9629449344
360PhosphorylationKHESGDSSGCIKPPK
CCCCCCCCCCCCCCC		42.2829449344
368PhosphorylationGCIKPPKSPLSPELI
CCCCCCCCCCCHHHE		36.5326074081
371PhosphorylationKPPKSPLSPELIQVE
CCCCCCCCHHHEEHH		21.5126074081
381PhosphorylationLIQVEDLTLVSQLSS
HEEHHHHHHHHHHCH		37.1227732954
394PhosphorylationSSSVINKTSPPQPVN
CHHCCCCCCCCCCCC		41.8130266825
395PhosphorylationSSVINKTSPPQPVNP
HHCCCCCCCCCCCCC		35.8726657352
409PhosphorylationPPRPFKHSERRRRSQ
CCCCCCHHHHHHHHH		33.1324719451
415PhosphorylationHSERRRRSQRLATLP
HHHHHHHHHHHHCCC		20.17-
420PhosphorylationRRSQRLATLPMPDDS
HHHHHHHCCCCCCCC		35.6726074081
427PhosphorylationTLPMPDDSVEKVSSP
CCCCCCCCCEECCCC		39.2926074081
432PhosphorylationDDSVEKVSSPSPATD
CCCCEECCCCCCCCC		47.8230266825
433PhosphorylationDSVEKVSSPSPATDG
CCCEECCCCCCCCCC		32.1730266825
435PhosphorylationVEKVSSPSPATDGKV
CEECCCCCCCCCCCE		29.1630266825
438PhosphorylationVSSPSPATDGKVFSI
CCCCCCCCCCCEEEE		48.9829255136
441AcetylationPSPATDGKVFSISSQ
CCCCCCCCEEEECCC		42.8026051181
478PhosphorylationPCLPLDLSRGSEVTA
CCCCCCCCCCCCEEC		33.9727135362
481PhosphorylationPLDLSRGSEVTAPVA
CCCCCCCCCEECCCC		27.9927135362
484PhosphorylationLSRGSEVTAPVASDS
CCCCCCEECCCCCCC		22.61-
489PhosphorylationEVTAPVASDSSYRNE
CEECCCCCCCHHCCC		37.9524275569
492PhosphorylationAPVASDSSYRNECPR
CCCCCCCHHCCCCCC		32.8524275569
514AcetylationMLPNPSSKAIADGRG
CCCCCCHHHHHCCCC		48.4226051181
529PhosphorylationAPAAAGISKTEKKVK
CCCHHCCCCCCCCEE		32.38-
530AcetylationPAAAGISKTEKKVKL
CCHHCCCCCCCCEEC		59.8025953088
530SumoylationPAAAGISKTEKKVKL
CCHHCCCCCCCCEEC		59.8028112733
531PhosphorylationAAAGISKTEKKVKLE
CHHCCCCCCCCEECC		46.37-
547AcetylationKSSTAFGKRKEKDKE
CCCCCCCCHHHHHHH		54.5725953088
562 (in isoform 4)Phosphorylation-48.62-
583PhosphorylationKKSKQHDYSDYEDSS
HHHCCCCCCCCCCCH		11.0030266825
584PhosphorylationKSKQHDYSDYEDSSL
HHCCCCCCCCCCCHH		39.5130266825
586PhosphorylationKQHDYSDYEDSSLEF
CCCCCCCCCCCHHHH		18.7230266825
589PhosphorylationDYSDYEDSSLEFLER
CCCCCCCCHHHHHHH		25.5330266825
590PhosphorylationYSDYEDSSLEFLERC
CCCCCCCHHHHHHHC		44.2123927012
598PhosphorylationLEFLERCSSPLTRSS
HHHHHHCCCCCCCCC		41.0127251275
599PhosphorylationEFLERCSSPLTRSSG
HHHHHCCCCCCCCCC		27.7924260401
602PhosphorylationERCSSPLTRSSGSSL
HHCCCCCCCCCCCCH		31.7127251275
604PhosphorylationCSSPLTRSSGSSLAS
CCCCCCCCCCCCHHH		33.54-
611PhosphorylationSSGSSLASRSMFTEK
CCCCCHHHHHCCCCC		30.1321955146
613PhosphorylationGSSLASRSMFTEKTT
CCCHHHHHCCCCCCC		18.7621955146
616PhosphorylationLASRSMFTEKTTTYQ
HHHHHCCCCCCCCCC		28.1221955146
618UbiquitinationSRSMFTEKTTTYQYP
HHHCCCCCCCCCCCC		48.38-
737AcetylationPGQRWSAKYRYDKEW
CCCCCCEEEECCHHH		25.4219608861
766UbiquitinationNYSHLNAKKIVSTHH
CCCCCCHHHHHHHHH		41.79-
813UbiquitinationWACSGKRKDQDQIIA
EEECCCCCCHHHHHH		64.3321906983
824UbiquitinationQIIAGVEKKIAQDTV
HHHHHHHHHHHHHHC		47.262190698
825UbiquitinationIIAGVEKKIAQDTVN
HHHHHHHHHHHHHCC		29.75-
851SumoylationEPPRLPLKMEGTYIT
CCCCCCCEEECEEEC		32.7228112733
865AcetylationTSEHSYQKPQSFGQD
CCCCCCCCCCCCCCC		36.4725953088
875PhosphorylationSFGQDCKSLADPGSS
CCCCCHHHHCCCCCC		34.8127732954
881PhosphorylationKSLADPGSSDDDDVS
HHHCCCCCCCCCCCC		35.6627422710
882PhosphorylationSLADPGSSDDDDVSS
HHCCCCCCCCCCCCC		51.4827422710
888PhosphorylationSSDDDDVSSLEEEQE
CCCCCCCCCHHHHHH		35.8827732954
889PhosphorylationSDDDDVSSLEEEQEF
CCCCCCCCHHHHHHH		39.3827732954
901UbiquitinationQEFHMRSKNSLQYSA
HHHHHCCHHHHHHHH		39.94-
909AcetylationNSLQYSAKEHGMPEK
HHHHHHHHHHCCCCC		44.2819608861
930UbiquitinationTVFVYNDKKGTEDPG
EEEEEECCCCCCCCC		49.84-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of P20L1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of P20L1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of P20L1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
A4_HUMANAPPphysical
21832049
WWP1_HUMANWWP1physical
21988832
KDM1A_HUMANKDM1Aphysical
23455924
ZN471_HUMANZNF471physical
25416956
P66B_HUMANGATAD2Bphysical
26186194
P66A_HUMANGATAD2Aphysical
26186194
MBD2_HUMANMBD2physical
26186194
MBD3_HUMANMBD3physical
26186194
CHD4_HUMANCHD4physical
26186194
CHD3_HUMANCHD3physical
26186194
MTA2_HUMANMTA2physical
26186194
MTA1_HUMANMTA1physical
26186194
MTA3_HUMANMTA3physical
26186194
RBBP7_HUMANRBBP7physical
26186194
IMA3_HUMANKPNA4physical
26186194
LIN9_HUMANLIN9physical
26186194
HDAC1_HUMANHDAC1physical
26186194
BC11A_HUMANBCL11Aphysical
26186194
MTA3_HUMANMTA3physical
28514442
MBD3_HUMANMBD3physical
28514442
P66B_HUMANGATAD2Bphysical
28514442
BC11A_HUMANBCL11Aphysical
28514442
P66A_HUMANGATAD2Aphysical
28514442
MBD2_HUMANMBD2physical
28514442
CHD4_HUMANCHD4physical
28514442
CHD3_HUMANCHD3physical
28514442
MTA2_HUMANMTA2physical
28514442
MTA1_HUMANMTA1physical
28514442
LIN9_HUMANLIN9physical
28514442
RBBP7_HUMANRBBP7physical
28514442
HDAC1_HUMANHDAC1physical
28514442
HDAC2_HUMANHDAC2physical
28514442
Drug and Disease Associations
Kegg Disease
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of P20L1_HUMAN

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Related Literatures of Post-Translational Modification

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