dbPTM

R3HD1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	R3HD1_HUMAN
UniProt AC	Q15032
Protein Name	R3H domain-containing protein 1
Gene Name	R3HDM1
Organism	Homo sapiens (Human).
Sequence Length	1099
Subcellular Localization
Protein Description
Protein Sequence	MRMSDTVTVKDETATMKDLEAEVKDTTRVENLIKSENYGKILVEKNEHCIENNIDLQRPLQSFGQTGKRSKSSSKLKLVRSLAVCEESPPPPAPEISQENQEKIQIQLTQSFEKEEKPSKDEAEKEKASDKLPRKMLSRDSSQEYTDSTGIDLHEFLVNTLKNNPRDRMMLLKLEQEILDFIGNNESPRKKFPPMTSYHRMLLHRVAAYFGLDHNVDQSGKSVIVNKTSNTRIPDQKFNEHIKDDKGEDFQKRYILKRDNSSFDKDDNQMRIRLKDDRRSKSIEEREEEYQRARDRIFSQDSLCSQENYIIDKRLQDEDASSTQQRRQIFRVNKDASGRSTNSHQSSTENELKYSEPRPWSSTDSDSSLRNLKPAVTKASSFSGISVLTRGDSSGSSKSIGRLSKTGSESSGSVGSSTGSLSHIQQPLPGTALSQSSHGAPVVYPTVSTHSSLSFDGGLNGQVASPSTSFFLLPLEAAGIPPGSILINPQTGQPFINPDGSPVVYNPPMTQQPVRSQVPGPPQPPLPAPPQQPAANHIFSQDNLGSQFSHMSLARQPSADGSDPHAAMFQSTVVLQSPQQSGYIMTAAPPPHPPPPPPPPPPPPPLPPGQPVPTAGYPASGHPVSQPVLQQQGYIQQPSPQMPACYCAPGHYHSSQPQYRPVPSVHYNSHLNQPLPQPAQQTGYQVIPNQQQNYQGIVGVQQPQSQSLVSGQPNSIGNQIQGVVIPYTSVPTYQVSLPQGSQGIPHQTYQQPVMFPNQSNQGSMPTTGMPVYYSVIPPGQQNNLSSSVGYLQHPGSEQVQFPRTTSPCSSQQLQGHQCTAGPPPPPGGGMVMMQLSVPNNPQSCAHSPPQWKQNKYYCDHQRGQKCVEFSSVDNIVQHSPQLSSPIISPAQSPAPAQLSTLKTVRPSGPPLSIMPQFSRPFVPGQGDSRYPLLGQPLQYNPPAVLHGHIPNQQGQPGSRHGNRGRRQAKKAASTDLGAGETVVGKVLEITELPDGITRMEAEKLFGELFKIGAKIRWLRDPQSQPRRHPLCCGSGDNTANPERSKPSDLASTYTVLATFPSISAAQNALKKQINSVNKFKLRTSKKHYDFHILERASSQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MRMSDTVTVKD ----CCCCCEEEECC	36.04	22964224
6	Phosphorylation	--MRMSDTVTVKDET --CCCCCEEEECCCC	15.69	26503514
8	Phosphorylation	MRMSDTVTVKDETAT CCCCCEEEECCCCCC	24.75	28787133
13	Phosphorylation	TVTVKDETATMKDLE EEEECCCCCCHHHHH	37.25	28787133
15	Phosphorylation	TVKDETATMKDLEAE EECCCCCCHHHHHHH	31.97	22964224
24	Ubiquitination	KDLEAEVKDTTRVEN HHHHHHHCCCHHHHH	40.64	29967540
26	Phosphorylation	LEAEVKDTTRVENLI HHHHHCCCHHHHHHH	15.70	28787133
40	Acetylation	IKSENYGKILVEKNE HHHCCCCCEEEECCH	23.62	25953088
40	Ubiquitination	IKSENYGKILVEKNE HHHCCCCCEEEECCH	23.62	29967540
43 (in isoform 4)	Phosphorylation	-	12.86	27067055
53 (in isoform 4)	Phosphorylation	-	19.16	27067055
67 (in isoform 2)	Phosphorylation	-	18.58	25849741
88	Phosphorylation	SLAVCEESPPPPAPE HHHHHCCCCCCCCCC	22.03	25159151
106	Ubiquitination	ENQEKIQIQLTQSFE HHHHHHHHHHHHHHH	4.06	29967540
109	Phosphorylation	EKIQIQLTQSFEKEE HHHHHHHHHHHHCCC	13.04	24117733
111	Phosphorylation	IQIQLTQSFEKEEKP HHHHHHHHHHCCCCC	30.09	25159151
118	Ubiquitination	SFEKEEKPSKDEAEK HHHCCCCCCHHHHHH	50.30	29967540
131	Acetylation	EKEKASDKLPRKMLS HHHHHHHHCCHHHHC	58.87	12429955
138	Phosphorylation	KLPRKMLSRDSSQEY HCCHHHHCCCCCCCC	30.46	22617229
141	Phosphorylation	RKMLSRDSSQEYTDS HHHHCCCCCCCCCCC	32.58	30278072
142	Phosphorylation	KMLSRDSSQEYTDST HHHCCCCCCCCCCCC	31.18	30278072
145	Phosphorylation	SRDSSQEYTDSTGID CCCCCCCCCCCCCCC	14.28	21712546
146	Phosphorylation	RDSSQEYTDSTGIDL CCCCCCCCCCCCCCH	23.79	21712546
148	Phosphorylation	SSQEYTDSTGIDLHE CCCCCCCCCCCCHHH	22.27	23403867
149	Phosphorylation	SQEYTDSTGIDLHEF CCCCCCCCCCCHHHH	40.75	23403867
160	Phosphorylation	LHEFLVNTLKNNPRD HHHHHHHHHHCCHHH	31.46	23090842
162	Ubiquitination	EFLVNTLKNNPRDRM HHHHHHHHCCHHHHH	53.27	29967540
187	Phosphorylation	DFIGNNESPRKKFPP HHHCCCCCCCCCCCC	31.93	30278072
198	Phosphorylation	KFPPMTSYHRMLLHR CCCCCHHHHHHHHHH	5.58	-
226	Phosphorylation	SGKSVIVNKTSNTRI CCCEEEEECCCCCCC	30.66	32645325
238	Phosphorylation	TRIPDQKFNEHIKDD CCCCCCCHHHHCCCC	12.32	32645325
254	Phosphorylation	GEDFQKRYILKRDNS CCCHHHHHEEECCCC	20.03	21964256
261	Phosphorylation	YILKRDNSSFDKDDN HEEECCCCCCCCCCC	36.35	23911959
262	Phosphorylation	ILKRDNSSFDKDDNQ EEECCCCCCCCCCCE	43.66	23401153
280	Phosphorylation	RLKDDRRSKSIEERE EECCHHHCCCHHHHH	31.48	21955146
282	Phosphorylation	KDDRRSKSIEEREEE CCHHHCCCHHHHHHH	36.16	23401153
286	Methylation	RSKSIEEREEEYQRA HCCCHHHHHHHHHHH	43.78	24384461
290	Phosphorylation	IEEREEEYQRARDRI HHHHHHHHHHHHHHH	13.43	28796482
293 (in isoform 2)	Phosphorylation	-	11.38	18669648
299	Phosphorylation	RARDRIFSQDSLCSQ HHHHHHHCCCCCCCC	30.61	23401153
302	Phosphorylation	DRIFSQDSLCSQENY HHHHCCCCCCCCCCE	24.52	28450419
305	Phosphorylation	FSQDSLCSQENYIID HCCCCCCCCCCEEEC	45.91	29978859
309	Phosphorylation	SLCSQENYIIDKRLQ CCCCCCCEEECHHHC	9.86	-
325	Phosphorylation	EDASSTQQRRQIFRV CCCCCHHHHHHHEEC	42.48	32142685
337	Phosphorylation	FRVNKDASGRSTNSH EECCCCCCCCCCCCC	44.89	28450419
340	Phosphorylation	NKDASGRSTNSHQSS CCCCCCCCCCCCCCC	35.15	25849741
341	Phosphorylation	KDASGRSTNSHQSST CCCCCCCCCCCCCCC	39.10	28450419
343	Phosphorylation	ASGRSTNSHQSSTEN CCCCCCCCCCCCCCC	24.00	28450419
346	Phosphorylation	RSTNSHQSSTENELK CCCCCCCCCCCCCCC	33.53	25627689
347	Phosphorylation	STNSHQSSTENELKY CCCCCCCCCCCCCCC	32.92	23401153
348	Phosphorylation	TNSHQSSTENELKYS CCCCCCCCCCCCCCC	48.34	25262027
349 (in isoform 2)	Phosphorylation	-	51.13	25159151
354	Phosphorylation	STENELKYSEPRPWS CCCCCCCCCCCCCCC	30.78	29978859
355	Phosphorylation	TENELKYSEPRPWSS CCCCCCCCCCCCCCC	39.27	29978859
361	Phosphorylation	YSEPRPWSSTDSDSS CCCCCCCCCCCCHHH	26.49	23401153
362	Phosphorylation	SEPRPWSSTDSDSSL CCCCCCCCCCCHHHH	32.15	23401153
363	Phosphorylation	EPRPWSSTDSDSSLR CCCCCCCCCCHHHHH	33.72	25159151
365	Phosphorylation	RPWSSTDSDSSLRNL CCCCCCCCHHHHHHC	39.21	21712546
367	Phosphorylation	WSSTDSDSSLRNLKP CCCCCCHHHHHHCHH	34.91	28450419
368	Phosphorylation	SSTDSDSSLRNLKPA CCCCCHHHHHHCHHC	36.02	28450419
372 (in isoform 2)	Phosphorylation	-	5.93	25159151
380	Phosphorylation	KPAVTKASSFSGISV HHCHHHCCCCCCEEE	33.21	29255136
381	Phosphorylation	PAVTKASSFSGISVL HCHHHCCCCCCEEEE	28.43	29255136
383	Phosphorylation	VTKASSFSGISVLTR HHHCCCCCCEEEEEC	36.85	30266825
386	Phosphorylation	ASSFSGISVLTRGDS CCCCCCEEEEECCCC	18.01	22167270
389	Phosphorylation	FSGISVLTRGDSSGS CCCEEEEECCCCCCC	30.37	23927012
393	Phosphorylation	SVLTRGDSSGSSKSI EEEECCCCCCCCCCC	39.15	25159151
394	Phosphorylation	VLTRGDSSGSSKSIG EEECCCCCCCCCCCC	47.65	28450419
396	Phosphorylation	TRGDSSGSSKSIGRL ECCCCCCCCCCCCCE	36.22	28450419
397	Phosphorylation	RGDSSGSSKSIGRLS CCCCCCCCCCCCCEE	33.67	28450419
399	Phosphorylation	DSSGSSKSIGRLSKT CCCCCCCCCCCEECC	32.02	20363803
404	Phosphorylation	SKSIGRLSKTGSESS CCCCCCEECCCCCCC	27.15	20363803
501	Phosphorylation	PFINPDGSPVVYNPP CCCCCCCCCEEECCC	23.15	25627689
552	Phosphorylation	GSQFSHMSLARQPSA CCCCCHHHHCCCCCC	17.29	26074081
558	Phosphorylation	MSLARQPSADGSDPH HHHCCCCCCCCCCCC	30.56	26074081
562	Phosphorylation	RQPSADGSDPHAAMF CCCCCCCCCCCHHHE	48.82	26074081
646	Phosphorylation	SPQMPACYCAPGHYH CCCCCCEEECCCCCC	8.18	-
727	Ubiquitination	IQGVVIPYTSVPTYQ CCEEEECCCCCCEEE	10.67	29967540
796	Phosphorylation	GYLQHPGSEQVQFPR CCCCCCCCCCCCCCC	29.34	26074081
800	Ubiquitination	HPGSEQVQFPRTTSP CCCCCCCCCCCCCCC	42.17	29967540
804	Phosphorylation	EQVQFPRTTSPCSSQ CCCCCCCCCCCCCCH	31.68	26074081
805	Phosphorylation	QVQFPRTTSPCSSQQ CCCCCCCCCCCCCHH	31.77	26074081
806	Phosphorylation	VQFPRTTSPCSSQQL CCCCCCCCCCCCHHC	24.24	26074081
809	Phosphorylation	PRTTSPCSSQQLQGH CCCCCCCCCHHCCCC	34.27	26074081
810	Phosphorylation	RTTSPCSSQQLQGHQ CCCCCCCCHHCCCCC	28.76	26074081
819	Phosphorylation	QLQGHQCTAGPPPPP HCCCCCCCCCCCCCC	28.25	28348404
847	Phosphorylation	NPQSCAHSPPQWKQN CCCCCCCCCCCHHHC	21.54	26846344
855	Ubiquitination	PPQWKQNKYYCDHQR CCCHHHCCCCCCCCC	34.79	29967540
856	Ubiquitination	PQWKQNKYYCDHQRG CCHHHCCCCCCCCCC	19.51	29967540
857	Phosphorylation	QWKQNKYYCDHQRGQ CHHHCCCCCCCCCCC	7.94	-
857	Ubiquitination	QWKQNKYYCDHQRGQ CHHHCCCCCCCCCCC	7.94	29967540
870	Phosphorylation	GQKCVEFSSVDNIVQ CCCEEEECCCCHHHH	18.88	25850435
871	Phosphorylation	QKCVEFSSVDNIVQH CCEEEECCCCHHHHC	38.52	25850435
875	Ubiquitination	EFSSVDNIVQHSPQL EECCCCHHHHCCCCC	2.46	29967540
879	Phosphorylation	VDNIVQHSPQLSSPI CCHHHHCCCCCCCCC	9.39	27080861
883	Phosphorylation	VQHSPQLSSPIISPA HHCCCCCCCCCCCCC	28.90	25850435
884	Phosphorylation	QHSPQLSSPIISPAQ HCCCCCCCCCCCCCC	28.80	25850435
888	Phosphorylation	QLSSPIISPAQSPAP CCCCCCCCCCCCCCC	18.20	25850435
892	Phosphorylation	PIISPAQSPAPAQLS CCCCCCCCCCCHHHC	25.74	27251275
912	Phosphorylation	RPSGPPLSIMPQFSR CCCCCCCCCCCCCCC	23.71	30576142
918	Phosphorylation	LSIMPQFSRPFVPGQ CCCCCCCCCCCCCCC	33.52	30576142
929	Asymmetric dimethylarginine	VPGQGDSRYPLLGQP CCCCCCCCCCCCCCC	41.66	-
929	Methylation	VPGQGDSRYPLLGQP CCCCCCCCCCCCCCC	41.66	24129315
930	Ubiquitination	PGQGDSRYPLLGQPL CCCCCCCCCCCCCCC	11.37	29967540
948	Ubiquitination	PPAVLHGHIPNQQGQ CCCEEECCCCCCCCC	22.91	29967540
950	Ubiquitination	AVLHGHIPNQQGQPG CEEECCCCCCCCCCC	27.23	29967540
973	Phosphorylation	RQAKKAASTDLGAGE HHHHHHHCCCCCCCC	27.58	29255136
974	Phosphorylation	QAKKAASTDLGAGET HHHHHHCCCCCCCCE	30.43	30266825
981	Phosphorylation	TDLGAGETVVGKVLE CCCCCCCEEEEEEEE	21.41	23927012
985	Ubiquitination	AGETVVGKVLEITEL CCCEEEEEEEEEEEC	31.85	29967540
986	Ubiquitination	GETVVGKVLEITELP CCEEEEEEEEEEECC	4.82	29967540
1003	Ubiquitination	ITRMEAEKLFGELFK CCHHHHHHHHHHHHH	57.05	29967540
1004	Ubiquitination	TRMEAEKLFGELFKI CHHHHHHHHHHHHHH	5.12	29967540
1023	Ubiquitination	RWLRDPQSQPRRHPL EECCCCCCCCCCCCC	47.76	29967540
1034	Phosphorylation	RHPLCCGSGDNTANP CCCCCCCCCCCCCCC	29.11	28555341
1075	Phosphorylation	ALKKQINSVNKFKLR HHHHHHHHCCCCCCC	28.79	-
1078	Ubiquitination	KQINSVNKFKLRTSK HHHHHCCCCCCCCCC	41.54	29967540
1079	Ubiquitination	QINSVNKFKLRTSKK HHHHCCCCCCCCCCC	8.32	29967540
1088	Phosphorylation	LRTSKKHYDFHILER CCCCCCCCCHHHHHH	29.23	-
1097	Phosphorylation	FHILERASSQ----- HHHHHHHCCC-----	35.18	26074081
1098	Phosphorylation	HILERASSQ------ HHHHHHCCC------	38.64	28985074

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of R3HD1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of R3HD1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of R3HD1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of R3HD1_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of R3HD1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-138 AND SER-973, ANDMASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-381, AND MASSSPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-187, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry."; Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.; Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-973, AND MASSSPECTROMETRY.	17287340 [Abstract]
"Robust phosphoproteomic profiling of tyrosine phosphorylation sitesfrom human T cells using immobilized metal affinity chromatography andtandem mass spectrometry."; Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M.,Peters E.C.; Anal. Chem. 76:2763-2772(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-337, AND MASSSPECTROMETRY.	15144186 [Abstract]