NELFD_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NELFD_MOUSE
• UniProt AC: Q922L6
• Protein Name: Negative elongation factor D
• Gene Name: Nelfcd
• Organism: Mus musculus (Mouse).
• Sequence Length: 591
• Subcellular Localization: Nucleus .
• Protein Description: Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. Binds RNA which may help to stabilize the NELF complex on nucleic acid. In vitro, the NELFA:NELFCD subcomplex binds to ssDNA and ssRNA in a sequence- and structure-dependent manner..
• Protein Sequence: MAGPAPGTIMGEDYFGNASEWGEEADGGQHQEDDSGEGEDDAEVQQECLHKFSTRDYIMEPSIFNTLKRYFQAGGSPENVIQLLSENYTAVAQTVNLLAEWLIQTGVEPVQVQETVENHLKSLLIKHFDPRKADSIFTEEGETPAWLEQMIAHTTWRDLFYKLAEAHPDCLMLNFTVKLISDAGYQGEITSVSTACQQLEVFSRVLRTSLATILDGGEENLEKNLPEFAKMVCHGEHTYLFAQAMMSVLAQEEQGGSAVRRVAQEVQRFAQEKGHDASQITLALGTAASYPRACQALGAMLSRGALNPADITVLFKMFTSMDPPPVELIRVPAFLDLFMQSLFKPGAKINQDHKHKYIHILAYAASVVETWKKNKRVSIGKDELKSTSKAIETVHNLCCNENKGASELVAELSTLYQCIRFPVVAMGVLKWVDWTVSEPRYFQLQTDHTPVHLALLDEISTCHQLLHPQVLQLLVKLFETEHSQLDVMEQLELKKTLLDRMVHLLSRGYVLPVVSYIRKCLEKLDTDISLIRYFVTEVLDVIAPPYTSDFVQLFLPILENDSIAGTIKAEGEHDPVTEFIAHCKSNFIVVN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
35	Phosphorylation	GQHQEDDSGEGEDDA CCCCCCCCCCCCCHH	51.57	25338131
319	Phosphorylation	TVLFKMFTSMDPPPV HHHHHHHHCCCCCCC	21.46	27742792
320	Phosphorylation	VLFKMFTSMDPPPVE HHHHHHHCCCCCCCH	15.21	27742792
526	Phosphorylation	KCLEKLDTDISLIRY HHHHHCCCCHHHHHH	45.74	25293948
529	Phosphorylation	EKLDTDISLIRYFVT HHCCCCHHHHHHHHH	22.13	25293948

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NELFD_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NELFD_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NELFD_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ANDR_MOUSE	Ar	physical	20069563

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.